Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect

• Published in: Nature communications Vol. 10; no. 1; pp. 5566 - 16
• Main Authors: Cheng, Aoxing, Zhang, Peng, Wang, Bo, Yang, Dongdong, Duan, Xiaotao, Jiang, Yongliang, Xu, Tian, Jiang, Ya, Shi, Jiahui, Ding, Chengtao, Wu, Gao, Sang, Zhihong, Wu, Qiang, Wang, Hua, Wu, Mian, Zhang, Zhiyong, Pan, Xin, Pan, Yue-yin, Gao, Ping, Zhang, Huafeng, Zhou, Cong-zhao, Guo, Jing, Yang, Zhenye
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.12.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 14/33; 631/67/2327; 631/67/395; 82/16; 82/58; 82/80; 96/10; Animals; Aurora Kinase A - antagonists & inhibitors; Aurora Kinase A - metabolism; Azepines - pharmacology; Cancer; Cell culture; Cell Line, Tumor; Glycolysis; HEK293 Cells; HeLa Cells; Humanities and Social Sciences; Humans; Intermediates; Isoenzymes - genetics; Isoenzymes - metabolism; Kinases; L-Lactate dehydrogenase; L-Lactate Dehydrogenase - genetics; L-Lactate Dehydrogenase - metabolism; Lactate dehydrogenase; Lactic acid; Lactic Acid - metabolism; Male; Mice, Inbred BALB C; Mice, Nude; multidisciplinary; Mutation; NAD; NADH; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Nicotinamide adenine dinucleotide; Phosphorylation; Pyrimidines - pharmacology; Pyruvic acid; Pyruvic Acid - metabolism; Pyruvic Acid - pharmacology; Regeneration; Science; Science (multidisciplinary); Serine; Serine - genetics; Serine - metabolism; Substrate inhibition; Substrate Specificity - drug effects; Tumor Burden - drug effects; Tumors; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation

Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether Aurora-A is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subun...