LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma

• Published in: Cell death & disease Vol. 12; no. 1; pp. 69 - 15
• Main Authors: Guo, Zhen, Wang, You-Hong, Xu, Heng, Yuan, Chun-Su, Zhou, Hong-Hao, Huang, Wei-Hua, Wang, Hui, Zhang, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.01.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/2; 13/31; 13/51; 14/19; 14/32; 38/39; 631/337/1427/2191; 631/337/384/2568; 631/67/1536; 692/53/2422; 82/58; AKT protein; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell cycle; CHK1 protein; CHK2 protein; Comet assay; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; DNA-dependent protein kinase; Flow cytometry; Immunology; Immunoprecipitation; Ionizing radiation; Life Sciences; Nasopharyngeal carcinoma; Non-homologous end joining; Phosphorylation; Protein kinase C; Radiation therapy; Radioresistance; Radiosensitivity; Ribonucleic acid; RNA; Throat cancer

Radioresistance is the main obstacle in the clinical management of nasopharyngeal carcinoma (NPC). linc00312 is deregulated in a number of human cancers, including NPC. However, the detailed functions and underlying mechanisms of linc00312 in regulating radiosensitivity of NPC remains unknown. In th...