Lack of effect of colesevelam HCl on the single-dose pharmacokinetics of aspirin, atenolol, enalapril, phenytoin, rosiglitazone, and sitagliptin

• Published in: Diabetes research and clinical practice Vol. 104; no. 3; pp. 401 - 409
• Main Authors: He, Ling, Wickremasingha, Prachi, Lee, James, Tao, Ben, Mendell-Harary, Jeanne, Walker, Joseph, Wight, Douglas
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.06.2014
• Subjects: Adolescent; Adult; Allylamine - analogs & derivatives; Allylamine - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Anticholesteremic Agents - pharmacology; Anticonvulsants; Anticonvulsants - pharmacokinetics; Antihypertensive agents; Antihypertensive Agents - pharmacokinetics; Area Under Curve; Aspirin - pharmacokinetics; Atenolol - pharmacokinetics; Colesevelam; Colesevelam Hydrochloride; Dose-Response Relationship, Drug; Drug Interactions; Drug–drug interactions; Enalapril - pharmacokinetics; Endocrinology & Metabolism; Female; Humans; Hypoglycemic agents; Hypoglycemic Agents - pharmacokinetics; Male; Middle Aged; Phenytoin - pharmacokinetics; Pyrazines - pharmacokinetics; Sitagliptin Phosphate; Thiazolidinediones - pharmacokinetics; Tissue Distribution; Triazoles - pharmacokinetics; Young Adult; Anticonvulsants; Hypoglycemic agents; Colesevelam; Antihypertensive agents; Drug–drug interactions

Drug interactions with bile acid sequestrants are primarily due to the potential of these agents to bind to concomitant drugs. Six clinical studies were performed to determine the effects of colesevelam on the pharmacokinetics of aspirin, atenolol, enalapril, phenytoin, rosiglitazone, and sitaglipti...