Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome

• Published in: Scientific reports Vol. 12; no. 1; pp. 4187 - 12
• Main Authors: Raredon, Micha Sam Brickman, Yang, Junchen, Garritano, James, Wang, Meng, Kushnir, Dan, Schupp, Jonas Christian, Adams, Taylor S., Greaney, Allison M., Leiby, Katherine L., Kaminski, Naftali, Kluger, Yuval, Levchenko, Andre, Niklason, Laura E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/114/1314; 631/114/2114; 631/114/2164; 631/114/2408; 631/114/2415; 631/114/794; 631/532; 631/553; 631/553/1833; Cell signaling; Computer applications; Humanities and Social Sciences; Ligands; multidisciplinary; Network topologies; Receptor mechanisms; Science; Science (multidisciplinary)

Single-cell RNA-sequencing data has revolutionized our ability to understand of the patterns of cell–cell and ligand–receptor connectivity that influence the function of tissues and organs. However, the quantification and visualization of these patterns in a way that informs tissue biology are major...