Bruton’s tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response

• Published in: Cell death & disease Vol. 12; no. 5; p. 431
• Main Authors: Guan, Di, Wang, Zixi, Huo, Jianxin, Xu, Shengli, Lam, Kong-Peng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.04.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/106; 13/21; 13/31; 38/22; 38/23; 38/77; 631/250/249/2510/257; 631/250/256; 631/250/347; 64/110; 64/60; 692/420/256; Antibodies; Biochemistry; Biomedical and Life Sciences; Bruton's tyrosine kinase; Cell Biology; Cell Culture; Colitis; Dendritic cells; Digestive system; Gastrointestinal tract; Homeostasis; Immune system; Immunology; Inflammatory bowel disease; Inflammatory bowel diseases; Interleukin 12; Intestinal microflora; Intestine; Kinases; Life Sciences; Lymphocytes T; Microbiota; Protein-tyrosine kinase; Risk factors; Rodents

Inflammatory bowel disease (IBD) is driven by multiple genetic and environmental risk factors. Patients with mutations in Bruton’s tyrosine kinase (BTK) is known to manifest high prevalence of intestinal disorders including IBD. Although BTK mediates the signaling of various immune receptors, little...