Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice

Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here generate microRNA-targeted ZIKV clones that lose t...

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Published inNature communications Vol. 9; no. 1; pp. 5350 - 13
Main Authors Tsetsarkin, Konstantin A., Maximova, Olga A., Liu, Guangping, Kenney, Heather, Teterina, Natalia, Bloom, Marshall E., Grabowski, Jeffrey M., Mlera, Luwanika, Nagata, Bianca M., Moore, Ian, Martens, Craig, Amaro-Carambot, Emerito, Lamirande, Elaine W., Whitehead, Stephen S., Pletnev, Alexander G.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 17.12.2018
Nature Publishing Group
Nature Portfolio
Subjects
14/63
38/109
38/90
49/98
631/326/590/1867
631/326/596/2557
631/326/596/2563
631/337/384/331
Animals
Brain
Chlorocebus aethiops
Disease Models, Animal
Disease transmission
Epididymis
Epididymis - virology
Epithelial cells
Genome, Viral - genetics
Genomes
Humanities and Social Sciences
Immunity
Immunodeficiency
Infectivity
Macaca mulatta
Male
Mice
MicroRNAs - genetics
miRNA
Monkeys
multidisciplinary
Organs
Outbreaks
Pathogenesis
Reproductive system
Ribonucleic acid
RNA
Science
Science (multidisciplinary)
Seminiferous Tubules - virology
Sexual transmission
Tropism
Tubules
Vaccines
Vector-borne diseases
Vero Cells
Viruses
Zika virus
Zika Virus - genetics
Zika Virus - immunology
Zika Virus - pathogenicity
Zika Virus Infection - pathology
Zika Virus Infection - transmission
Zika Virus Infection - veterinary
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Abstract Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here generate microRNA-targeted ZIKV clones that lose the infectivity for (1) the cells inside seminiferous tubules of the testis, or (2) epithelial cells of the epididymis. We trace ZIKV dissemination in the MRT using an established mouse model of ZIKV pathogenesis. Our results support a model in which ZIKV infects the testis via a hematogenous route, while infection of the epididymis can occur via two routes: (1) hematogenous/lymphogenous and (2) excurrent testicular. Co-targeting of the ZIKV genome with brain-, testis-, and epididymis-specific microRNAs restricts virus infection of these organs, but does not affect virus-induced protective immunity in mice and monkeys. These defined alterations of ZIKV tropism represent a rational design of a safe live-attenuated ZIKV vaccine. The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to trace routes of ZIKV dissemination in the testis and epididymis and to generate immunogenic live-attenuated ZIKV vaccine candidate, restricted for MRT infection.
AbstractList The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to trace routes of ZIKV dissemination in the testis and epididymis and to generate immunogenic live-attenuated ZIKV vaccine candidate, restricted for MRT infection.
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here generate microRNA-targeted ZIKV clones that lose the infectivity for (1) the cells inside seminiferous tubules of the testis, or (2) epithelial cells of the epididymis. We trace ZIKV dissemination in the MRT using an established mouse model of ZIKV pathogenesis. Our results support a model in which ZIKV infects the testis via a hematogenous route, while infection of the epididymis can occur via two routes: (1) hematogenous/lymphogenous and (2) excurrent testicular. Co-targeting of the ZIKV genome with brain-, testis-, and epididymis-specific microRNAs restricts virus infection of these organs, but does not affect virus-induced protective immunity in mice and monkeys. These defined alterations of ZIKV tropism represent a rational design of a safe live-attenuated ZIKV vaccine. The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to trace routes of ZIKV dissemination in the testis and epididymis and to generate immunogenic live-attenuated ZIKV vaccine candidate, restricted for MRT infection.
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here generate microRNA-targeted ZIKV clones that lose the infectivity for (1) the cells inside seminiferous tubules of the testis, or (2) epithelial cells of the epididymis. We trace ZIKV dissemination in the MRT using an established mouse model of ZIKV pathogenesis. Our results support a model in which ZIKV infects the testis via a hematogenous route, while infection of the epididymis can occur via two routes: (1) hematogenous/lymphogenous and (2) excurrent testicular. Co-targeting of the ZIKV genome with brain-, testis-, and epididymis-specific microRNAs restricts virus infection of these organs, but does not affect virus-induced protective immunity in mice and monkeys. These defined alterations of ZIKV tropism represent a rational design of a safe live-attenuated ZIKV vaccine.
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here generate microRNA-targeted ZIKV clones that lose the infectivity for (1) the cells inside seminiferous tubules of the testis, or (2) epithelial cells of the epididymis. We trace ZIKV dissemination in the MRT using an established mouse model of ZIKV pathogenesis. Our results support a model in which ZIKV infects the testis via a hematogenous route, while infection of the epididymis can occur via two routes: (1) hematogenous/lymphogenous and (2) excurrent testicular. Co-targeting of the ZIKV genome with brain-, testis-, and epididymis-specific microRNAs restricts virus infection of these organs, but does not affect virus-induced protective immunity in mice and monkeys. These defined alterations of ZIKV tropism represent a rational design of a safe live-attenuated ZIKV vaccine.Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and developing live-attenuated vaccines. To elucidate routes of ZIKV dissemination in the MRT, we here generate microRNA-targeted ZIKV clones that lose the infectivity for (1) the cells inside seminiferous tubules of the testis, or (2) epithelial cells of the epididymis. We trace ZIKV dissemination in the MRT using an established mouse model of ZIKV pathogenesis. Our results support a model in which ZIKV infects the testis via a hematogenous route, while infection of the epididymis can occur via two routes: (1) hematogenous/lymphogenous and (2) excurrent testicular. Co-targeting of the ZIKV genome with brain-, testis-, and epididymis-specific microRNAs restricts virus infection of these organs, but does not affect virus-induced protective immunity in mice and monkeys. These defined alterations of ZIKV tropism represent a rational design of a safe live-attenuated ZIKV vaccine.
ArticleNumber 5350
Author Moore, Ian
Bloom, Marshall E.
Tsetsarkin, Konstantin A.
Maximova, Olga A.
Kenney, Heather
Liu, Guangping
Teterina, Natalia
Lamirande, Elaine W.
Mlera, Luwanika
Whitehead, Stephen S.
Nagata, Bianca M.
Pletnev, Alexander G.
Martens, Craig
Amaro-Carambot, Emerito
Grabowski, Jeffrey M.
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Cites_doi 10.1089/vim.2006.19.10
10.1016/j.placenta.2012.05.009
10.1371/journal.pntd.0004682
10.1038/s41467-017-00737-8
10.1093/nar/gkt1181
10.1016/S1473-3099(16)00138-9
10.3201/eid2102.141363
10.1056/NEJMc1604449
10.1006/bbrc.1996.1573
10.1016/j.virol.2010.06.014
10.15585/mmwr.mm6528e2
10.2471/BLT.17.181370
10.1097/QCO.0000000000000414
10.1016/j.cell.2016.11.016
10.1093/cid/cix967
10.1038/sdata.2014.5
10.1038/nm.4322
10.1016/j.immuni.2010.05.009
10.1016/j.chom.2018.04.003
10.1093/nar/gkw061
10.1038/nm0318-248
10.1128/JVI.02091-10
10.1016/S1473-3099(16)30320-6
10.1038/nature20556
10.1371/journal.ppat.1002465
10.1038/srep33088
10.1016/j.celrep.2017.01.056
10.1074/jbc.M111.328054
10.1128/JVI.75.17.8259-8267.2001
10.1186/s12610-015-0018-z
10.1128/JVI.00252-16
10.1002/jat.3326
10.1056/NEJMoa1711038
10.1093/biostatistics/kxm030
10.4269/ajtmh.16-0111
10.3389/fcimb.2017.00272
10.1016/j.ydbio.2007.09.009
10.1101/gad.1640608
10.14806/ej.17.1.200
10.1016/S0140-6736(17)31450-2
10.1016/j.cell.2007.04.040
10.1038/ncomms9959
10.1074/mcp.M900587-MCP200
10.1038/nm.4206
10.1016/j.ajpath.2017.12.019
10.1371/journal.pntd.0006691
10.1111/jvh.12510
10.2807/1560-7917.ES.2016.21.32.30314
10.1038/nmeth.1923
10.1038/embor.2008.74
10.1371/journal.pone.0135605
10.1016/j.ymeth.2007.10.008
10.1055/s-0036-1592312
10.1038/nrmicro2971
10.1371/journal.ppat.1006854
10.1095/biolreprod.115.132209
10.1172/JCI121735
10.1128/JVI.00133-18
10.1371/journal.pmed.1002203
10.3390/v10040198
10.3389/fmicb.2017.01554
10.1128/mBio.01114-16
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  year: 2018
  text: 2018-12-17
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PublicationTitle Nature communications
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References Davidson, Slavinski, Komoto, Rakeman, Weiss (CR5) 2016; 65
Pletnev, Bray, Hanley, Speicher, Elkins (CR60) 2001; 75
Park, Gaur, Lengyel, Peter (CR39) 2008; 22
Baud, Gubler, Schaub, Lanteri, Musso (CR1) 2017; 390
Mead (CR11) 2018; 378
Huits (CR54) 2017; 95
Dabaja (CR48) 2015; 25
Govero (CR18) 2016; 540
CR31
Tsetsarkin, Liu, Shen, Pletnev (CR40) 2016; 44
Sheng (CR17) 2017; 7
Bao (CR50) 2012; 287
Gornet, Bracero, Segars (CR13) 2016; 34
Langmead, Salzberg (CR64) 2012; 9
Clancy, Van Wettere, Siddharthan, Morrey, Julander (CR46) 2018; 188
Ma (CR20) 2016; 167
Rossi (CR24) 2016; 94
Pham, Langlois, TenOever (CR44) 2012; 8
Kozomara, Griffiths-Jones (CR65) 2014; 42
Gorman (CR51) 2018; 23
CR2
Arsuaga, Bujalance, Diaz-Menendez, Vazquez, Arribas (CR53) 2016; 16
CR4
CR47
Minami (CR36) 2014; 1
Landgraf (CR28) 2007; 129
Musso (CR6) 2015; 21
McDonald, Duggal, Ritter, Brault (CR21) 2018; 12
Duggal (CR19) 2017; 18
Blaney, Durbin, Murphy, Whitehead (CR42) 2006; 19
Shan (CR55) 2017; 8
Kuchen (CR33) 2010; 32
Martin (CR62) 2011; 17
Robinson, Smyth (CR66) 2008; 9
Mead, Hills, Brooks (CR14) 2018; 31
Zhang, Gurtu, Kain (CR57) 1996; 227
Mansuy (CR9) 2016; 16
Papaioannou (CR49) 2011; 10
CR16
Engel (CR58) 2010; 405
CR59
Tsetsarkin (CR45) 2016; 6
Aliota (CR23) 2016; 10
CR52
Sakurai (CR30) 2016; 36
Batista, Bourachot, Mateescu, Reyal, Mechta-Grigoriou (CR38) 2016; 7
Heiss, Maximova, Pletnev (CR43) 2011; 85
Shan (CR41) 2017; 23
Nixon (CR34) 2015; 93
Osuna (CR15) 2016; 22
Nixon (CR35) 2015; 10
tenOever (CR27) 2013; 11
Chen (CR32) 2017; 45
Ro, Park, Sanders, McCarrey, Yan (CR29) 2007; 311
Lazear, Diamond (CR3) 2016; 90
CR22
Nuovo (CR67) 2008; 44
Nicastri (CR7) 2016; 21
CR63
Barzon (CR12) 2018; 66
D’Ortenzio (CR8) 2016; 374
Percivalle, Zavattoni, Fausto, Rovida (CR10) 2017; 40
Morales-Prieto (CR56) 2012; 33
Meissner (CR61) 2016; 23
Simanjuntak (CR25) 2018; 14
Chakradhar (CR26) 2018; 24
Burk (CR37) 2008; 9
BL Heiss (7782_CR43) 2011; 85
ME Gornet (7782_CR13) 2016; 34
B Nixon (7782_CR34) 2015; 93
S Ro (7782_CR29) 2007; 311
7782_CR59
7782_CR16
GJ Nuovo (7782_CR67) 2008; 44
M Arsuaga (7782_CR53) 2016; 16
7782_CR52
MD Robinson (7782_CR66) 2008; 9
L Batista (7782_CR38) 2016; 7
K Minami (7782_CR36) 2014; 1
7782_CR4
KA Tsetsarkin (7782_CR45) 2016; 6
J Chen (7782_CR32) 2017; 45
E Nicastri (7782_CR7) 2016; 21
MJ Gorman (7782_CR51) 2018; 23
D Musso (7782_CR6) 2015; 21
A Kozomara (7782_CR65) 2014; 42
BR tenOever (7782_CR27) 2013; 11
A Davidson (7782_CR5) 2016; 65
W Ma (7782_CR20) 2016; 167
JM Mansuy (7782_CR9) 2016; 16
EM McDonald (7782_CR21) 2018; 12
CE Osuna (7782_CR15) 2016; 22
E Percivalle (7782_CR10) 2017; 40
R Huits (7782_CR54) 2017; 95
P Landgraf (7782_CR28) 2007; 129
SM Park (7782_CR39) 2008; 22
7782_CR22
AA Dabaja (7782_CR48) 2015; 25
AM Pham (7782_CR44) 2012; 8
7782_CR63
K Sakurai (7782_CR30) 2016; 36
MD Papaioannou (7782_CR49) 2011; 10
AR Engel (7782_CR58) 2010; 405
L Barzon (7782_CR12) 2018; 66
B Langmead (7782_CR64) 2012; 9
NK Duggal (7782_CR19) 2017; 18
HM Lazear (7782_CR3) 2016; 90
PS Mead (7782_CR14) 2018; 31
DM Morales-Prieto (7782_CR56) 2012; 33
7782_CR31
J Govero (7782_CR18) 2016; 540
S Kuchen (7782_CR33) 2010; 32
SL Rossi (7782_CR24) 2016; 94
U Burk (7782_CR37) 2008; 9
C Shan (7782_CR41) 2017; 23
AG Pletnev (7782_CR60) 2001; 75
G Zhang (7782_CR57) 1996; 227
EG Meissner (7782_CR61) 2016; 23
M Martin (7782_CR62) 2011; 17
PS Mead (7782_CR11) 2018; 378
7782_CR47
B Nixon (7782_CR35) 2015; 10
S Chakradhar (7782_CR26) 2018; 24
D Baud (7782_CR1) 2017; 390
7782_CR2
JE Blaney (7782_CR42) 2006; 19
Y Simanjuntak (7782_CR25) 2018; 14
KA Tsetsarkin (7782_CR40) 2016; 44
C Shan (7782_CR55) 2017; 8
ZY Sheng (7782_CR17) 2017; 7
CS Clancy (7782_CR46) 2018; 188
E D’Ortenzio (7782_CR8) 2016; 374
JQ Bao (7782_CR50) 2012; 287
MT Aliota (7782_CR23) 2016; 10
References_xml – ident: CR22
– volume: 19
  start-page: 10
  year: 2006
  end-page: 32
  ident: CR42
  article-title: Development of a live attenuated dengue virus vaccine using reverse genetics
  publication-title: Viral Immunol.
  doi: 10.1089/vim.2006.19.10
– volume: 33
  start-page: 725
  year: 2012
  end-page: 734
  ident: CR56
  article-title: MicroRNA expression profiles of trophoblastic cells
  publication-title: Placenta
  doi: 10.1016/j.placenta.2012.05.009
– volume: 10
  start-page: e0004682
  year: 2016
  ident: CR23
  article-title: Characterization of lethal Zika virus infection in AG129 mice
  publication-title: PLoS. Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0004682
– volume: 8
  year: 2017
  ident: CR55
  article-title: A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00737-8
– volume: 42
  start-page: D68
  year: 2014
  end-page: D73
  ident: CR65
  article-title: miRBase: annotating high confidence microRNAs using deep sequencing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt1181
– ident: CR4
– volume: 16
  start-page: 405
  year: 2016
  end-page: 405
  ident: CR9
  article-title: Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(16)00138-9
– ident: CR16
– volume: 45
  start-page: 4142
  year: 2017
  end-page: 4157
  ident: CR32
  article-title: MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins
  publication-title: Nucleic Acids Res.
– volume: 21
  start-page: 359
  year: 2015
  end-page: 361
  ident: CR6
  article-title: Potential sexual transmission of Zika virus
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2102.141363
– volume: 374
  start-page: 2195
  year: 2016
  end-page: 2198
  ident: CR8
  article-title: Evidence of sexual transmission of Zika virus
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc1604449
– volume: 227
  start-page: 707
  year: 1996
  end-page: 711
  ident: CR57
  article-title: An enhanced green fluorescent protein allows sensitive detection of gene transfer in mammalian cells
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1996.1573
– volume: 405
  start-page: 243
  year: 2010
  end-page: 252
  ident: CR58
  article-title: The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3′ non-coding region of the genome
  publication-title: Virology
  doi: 10.1016/j.virol.2010.06.014
– volume: 65
  start-page: 716
  year: 2016
  end-page: 717
  ident: CR5
  article-title: Suspected female-to-male sexual transmission of Zika virus - New York City, 2016
  publication-title: Mmwr-Morb. Mortal. Wkly. Rep.
  doi: 10.15585/mmwr.mm6528e2
– volume: 95
  start-page: 802
  year: 2017
  end-page: 809
  ident: CR54
  article-title: Zika virus in semen: a prospective cohort study of symptomatic travellers returning to Belgium
  publication-title: Bull. World Health Organ.
  doi: 10.2471/BLT.17.181370
– volume: 31
  start-page: 39
  year: 2018
  end-page: 44
  ident: CR14
  article-title: Zika virus as a sexually transmitted pathogen
  publication-title: Curr. Opin. Infect. Dis.
  doi: 10.1097/QCO.0000000000000414
– volume: 167
  start-page: 1511
  year: 2016
  end-page: 1524 e10
  ident: CR20
  article-title: Zika virus causes testis damage and leads to male infertility in mice
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.016
– volume: 40
  start-page: 197
  year: 2017
  end-page: 198
  ident: CR10
  article-title: Zika virus isolation from semen
  publication-title: New Microbiol.
– volume: 66
  start-page: 1173
  year: 2018
  end-page: 1180
  ident: CR12
  article-title: Virus and antibody dynamics in travelers with acute zika virus infection
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix967
– volume: 1
  year: 2014
  ident: CR36
  article-title: miRNA expression atlas in male rat
  publication-title: Sci. Data
  doi: 10.1038/sdata.2014.5
– volume: 23
  start-page: 763
  year: 2017
  end-page: 767
  ident: CR41
  article-title: A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
  publication-title: Nat. Med.
  doi: 10.1038/nm.4322
– volume: 32
  start-page: 828
  year: 2010
  end-page: 839
  ident: CR33
  article-title: Regulation of microRNA expression and abundance during lymphopoiesis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.05.009
– volume: 23
  start-page: 672
  year: 2018
  end-page: 685 e6
  ident: CR51
  article-title: An immunocompetent mouse odel of Zika virus infection
  publication-title: Cell. Host. Microbe
  doi: 10.1016/j.chom.2018.04.003
– volume: 44
  start-page: 3330
  year: 2016
  end-page: 3350
  ident: CR40
  article-title: Kissing-loop interaction between 5’ and 3′ ends of tick-borne Langat virus genome ‘bridges the gap’ between mosquito- and tick-borne flaviviruses in mechanisms of viral RNA cyclization: applications for virus attenuation and vaccine development
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw061
– volume: 24
  start-page: 248
  year: 2018
  end-page: 250
  ident: CR26
  article-title: Going live How microRNAs might bring living vaccines back into the fold
  publication-title: Nat. Med.
  doi: 10.1038/nm0318-248
– volume: 85
  start-page: 1464
  year: 2011
  end-page: 1472
  ident: CR43
  article-title: Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype
  publication-title: J. Virol.
  doi: 10.1128/JVI.02091-10
– volume: 16
  start-page: 1107
  year: 2016
  ident: CR53
  article-title: Probable sexual transmission of Zika virus from a vasectomised man
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(16)30320-6
– volume: 540
  start-page: 438
  year: 2016
  end-page: 442
  ident: CR18
  article-title: Zika virus infection damages the testes in mice
  publication-title: Nature
  doi: 10.1038/nature20556
– volume: 8
  start-page: e1002465
  year: 2012
  ident: CR44
  article-title: Replication in cells of hematopoietic origin is necessary for Dengue virus dissemination
  publication-title: PLoS. Pathog.
  doi: 10.1371/journal.ppat.1002465
– volume: 6
  year: 2016
  ident: CR45
  article-title: Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host
  publication-title: Sci. Rep.
  doi: 10.1038/srep33088
– volume: 18
  start-page: 1751
  year: 2017
  end-page: 1760
  ident: CR19
  article-title: Frequent zika virus sexual transmission and prolonged viral RNA shedding in an immunodeficient mouse model
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.01.056
– volume: 287
  start-page: 21686
  year: 2012
  end-page: 21698
  ident: CR50
  article-title: MicroRNA-449 and MicroRNA-34b/c function redundantly in murine testes by targeting E2F transcription factor-retinoblastoma protein (E2F-pRb) pathway
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.328054
– volume: 75
  start-page: 8259
  year: 2001
  end-page: 8267
  ident: CR60
  article-title: Tick-borne Langat/mosquito-borne dengue flavivirus chimera, a candidate live attenuated vaccine for protection against disease caused by members of the tick-borne encephalitis virus complex: evaluation in rhesus monkeys and in mosquitoes
  publication-title: J. Virol.
  doi: 10.1128/JVI.75.17.8259-8267.2001
– volume: 25
  year: 2015
  ident: CR48
  article-title: Possible germ cell-Sertoli cell interactions are critical for establishing appropriate expression levels for the Sertoli cell-specific MicroRNA, miR-202-5p, in human testis
  publication-title: Basic Clin. Androl.
  doi: 10.1186/s12610-015-0018-z
– volume: 90
  start-page: 4864
  year: 2016
  end-page: 4875
  ident: CR3
  article-title: Zika Virus: new clinical syndromes and its emergence in the western hemisphere
  publication-title: J. Virol.
  doi: 10.1128/JVI.00252-16
– volume: 36
  start-page: 1614
  year: 2016
  end-page: 1621
  ident: CR30
  article-title: MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.3326
– volume: 378
  start-page: 1377
  year: 2018
  end-page: 1385
  ident: CR11
  article-title: Zika virus shedding in semen of symptomatic infected men
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1711038
– ident: CR47
– ident: CR2
– volume: 9
  start-page: 321
  year: 2008
  end-page: 332
  ident: CR66
  article-title: Small-sample estimation of negative binomial dispersion, with applications to SAGE data
  publication-title: Biostatistics
  doi: 10.1093/biostatistics/kxm030
– volume: 94
  start-page: 1362
  year: 2016
  end-page: 1369
  ident: CR24
  article-title: Characterization of a novel murine model to study Zika virus
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.16-0111
– volume: 7
  start-page: 272
  year: 2017
  ident: CR17
  article-title: Sertoli cells are susceptible to ZIKV infection in mouse testis
  publication-title: Front. Cell Infect. Microbiol.
  doi: 10.3389/fcimb.2017.00272
– ident: CR63
– volume: 311
  start-page: 592
  year: 2007
  end-page: 602
  ident: CR29
  article-title: Cloning and expression profiling of testis-expressed microRNAs
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2007.09.009
– volume: 22
  start-page: 894
  year: 2008
  end-page: 907
  ident: CR39
  article-title: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
  publication-title: Genes Dev.
  doi: 10.1101/gad.1640608
– volume: 17
  start-page: 10
  year: 2011
  end-page: 12
  ident: CR62
  article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads
  publication-title: EMBnet. J.
  doi: 10.14806/ej.17.1.200
– volume: 390
  start-page: 2099
  year: 2017
  end-page: 2109
  ident: CR1
  article-title: An update on Zika virus infection
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31450-2
– volume: 129
  start-page: 1401
  year: 2007
  end-page: 1414
  ident: CR28
  article-title: A mammalian microRNA expression atlas based on small RNA library sequencing
  publication-title: Cell
  doi: 10.1016/j.cell.2007.04.040
– volume: 7
  year: 2016
  ident: CR38
  article-title: Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9959
– volume: 10
  start-page: M900587MCP200
  year: 2011
  ident: CR49
  article-title: Loss of Dicer in sertoli cells has a major impact on the testicular proteome of mice
  publication-title: Mol. Cell Proteom.
  doi: 10.1074/mcp.M900587-MCP200
– volume: 22
  start-page: 1448
  year: 2016
  end-page: 1455
  ident: CR15
  article-title: Zika viral dynamics and shedding in rhesus and cynomolgus macaques
  publication-title: Nat. Med.
  doi: 10.1038/nm.4206
– volume: 188
  start-page: 904
  year: 2018
  end-page: 915
  ident: CR46
  article-title: Comparative histopathologic lesions of the male reproductive tract during acute infection of Zika Virus in AG129 and Ifnar(-/-) Mice
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2017.12.019
– ident: CR52
– volume: 12
  start-page: e0006691
  year: 2018
  ident: CR21
  article-title: Infection of epididymal epithelial cells and leukocytes drives seminal shedding of Zika virus in a mouse model
  publication-title: PLoS. Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0006691
– ident: CR31
– volume: 23
  start-page: 496
  year: 2016
  end-page: 505
  ident: CR61
  article-title: Achieving sustained virologic response after interferon-free hepatitis C virus treatment correlates with hepatic interferon gene expression changes independent of cirrhosis
  publication-title: J. Viral Hepat.
  doi: 10.1111/jvh.12510
– volume: 21
  start-page: 6
  year: 2016
  end-page: 9
  ident: CR7
  article-title: Persistent detection of Zika virus RNA in semen for six months after symptom onset in a traveller returning from Haiti to Italy, February 2016
  publication-title: Eur. Surveill.
  doi: 10.2807/1560-7917.ES.2016.21.32.30314
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: CR64
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 9
  start-page: 582
  year: 2008
  end-page: 589
  ident: CR37
  article-title: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2008.74
– volume: 10
  start-page: e0135605
  year: 2015
  ident: CR35
  article-title: Next generation sequencing analysis reveals segmental patterns of microRNA expression in mouse epididymal epithelial cells
  publication-title: PLoS. ONE
  doi: 10.1371/journal.pone.0135605
– ident: CR59
– volume: 44
  start-page: 39
  year: 2008
  end-page: 46
  ident: CR67
  article-title: In situ detection of precursor and mature microRNAs in paraffin embedded, formalin fixed tissues and cell preparations
  publication-title: Methods
  doi: 10.1016/j.ymeth.2007.10.008
– volume: 34
  start-page: 285
  year: 2016
  end-page: 292
  ident: CR13
  article-title: Zika virus in semen: what we know and what we need to know
  publication-title: Semin. Reprod. Med.
  doi: 10.1055/s-0036-1592312
– volume: 11
  start-page: 169
  year: 2013
  end-page: 180
  ident: CR27
  article-title: RNA viruses and the host microRNA machinery
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2971
– volume: 14
  start-page: e1006854
  year: 2018
  ident: CR25
  article-title: Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission
  publication-title: PLoS. Pathog.
  doi: 10.1371/journal.ppat.1006854
– volume: 93
  start-page: 91
  year: 2015
  ident: CR34
  article-title: The microRNA signature of mouse spermatozoa is substantially modified during epididymal maturation
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod.115.132209
– volume: 21
  start-page: 359
  year: 2015
  ident: 7782_CR6
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2102.141363
– volume: 95
  start-page: 802
  year: 2017
  ident: 7782_CR54
  publication-title: Bull. World Health Organ.
  doi: 10.2471/BLT.17.181370
– ident: 7782_CR16
  doi: 10.1172/JCI121735
– ident: 7782_CR31
– volume: 32
  start-page: 828
  year: 2010
  ident: 7782_CR33
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.05.009
– volume: 42
  start-page: D68
  year: 2014
  ident: 7782_CR65
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt1181
– volume: 11
  start-page: 169
  year: 2013
  ident: 7782_CR27
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2971
– ident: 7782_CR52
  doi: 10.1128/JVI.00133-18
– volume: 25
  year: 2015
  ident: 7782_CR48
  publication-title: Basic Clin. Androl.
  doi: 10.1186/s12610-015-0018-z
– volume: 7
  start-page: 272
  year: 2017
  ident: 7782_CR17
  publication-title: Front. Cell Infect. Microbiol.
  doi: 10.3389/fcimb.2017.00272
– volume: 17
  start-page: 10
  year: 2011
  ident: 7782_CR62
  publication-title: EMBnet. J.
  doi: 10.14806/ej.17.1.200
– ident: 7782_CR4
  doi: 10.1371/journal.pmed.1002203
– volume: 16
  start-page: 405
  year: 2016
  ident: 7782_CR9
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(16)00138-9
– volume: 18
  start-page: 1751
  year: 2017
  ident: 7782_CR19
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.01.056
– volume: 90
  start-page: 4864
  year: 2016
  ident: 7782_CR3
  publication-title: J. Virol.
  doi: 10.1128/JVI.00252-16
– volume: 14
  start-page: e1006854
  year: 2018
  ident: 7782_CR25
  publication-title: PLoS. Pathog.
  doi: 10.1371/journal.ppat.1006854
– volume: 12
  start-page: e0006691
  year: 2018
  ident: 7782_CR21
  publication-title: PLoS. Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0006691
– ident: 7782_CR59
  doi: 10.1093/nar/gkw061
– volume: 8
  start-page: e1002465
  year: 2012
  ident: 7782_CR44
  publication-title: PLoS. Pathog.
  doi: 10.1371/journal.ppat.1002465
– volume: 10
  start-page: e0135605
  year: 2015
  ident: 7782_CR35
  publication-title: PLoS. ONE
  doi: 10.1371/journal.pone.0135605
– volume: 40
  start-page: 197
  year: 2017
  ident: 7782_CR10
  publication-title: New Microbiol.
– volume: 311
  start-page: 592
  year: 2007
  ident: 7782_CR29
  publication-title: Dev. Biol.
  doi: 10.1016/j.ydbio.2007.09.009
– volume: 31
  start-page: 39
  year: 2018
  ident: 7782_CR14
  publication-title: Curr. Opin. Infect. Dis.
  doi: 10.1097/QCO.0000000000000414
– volume: 129
  start-page: 1401
  year: 2007
  ident: 7782_CR28
  publication-title: Cell
  doi: 10.1016/j.cell.2007.04.040
– ident: 7782_CR47
  doi: 10.3390/v10040198
– volume: 23
  start-page: 496
  year: 2016
  ident: 7782_CR61
  publication-title: J. Viral Hepat.
  doi: 10.1111/jvh.12510
– volume: 9
  start-page: 321
  year: 2008
  ident: 7782_CR66
  publication-title: Biostatistics
  doi: 10.1093/biostatistics/kxm030
– ident: 7782_CR63
– volume: 34
  start-page: 285
  year: 2016
  ident: 7782_CR13
  publication-title: Semin. Reprod. Med.
  doi: 10.1055/s-0036-1592312
– volume: 390
  start-page: 2099
  year: 2017
  ident: 7782_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31450-2
– volume: 374
  start-page: 2195
  year: 2016
  ident: 7782_CR8
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc1604449
– volume: 93
  start-page: 91
  year: 2015
  ident: 7782_CR34
  publication-title: Biol. Reprod.
  doi: 10.1095/biolreprod.115.132209
– volume: 7
  year: 2016
  ident: 7782_CR38
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9959
– volume: 65
  start-page: 716
  year: 2016
  ident: 7782_CR5
  publication-title: Mmwr-Morb. Mortal. Wkly. Rep.
  doi: 10.15585/mmwr.mm6528e2
– volume: 36
  start-page: 1614
  year: 2016
  ident: 7782_CR30
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.3326
– volume: 23
  start-page: 763
  year: 2017
  ident: 7782_CR41
  publication-title: Nat. Med.
  doi: 10.1038/nm.4322
– volume: 6
  year: 2016
  ident: 7782_CR45
  publication-title: Sci. Rep.
  doi: 10.1038/srep33088
– ident: 7782_CR2
  doi: 10.3389/fmicb.2017.01554
– volume: 33
  start-page: 725
  year: 2012
  ident: 7782_CR56
  publication-title: Placenta
  doi: 10.1016/j.placenta.2012.05.009
– volume: 167
  start-page: 1511
  year: 2016
  ident: 7782_CR20
  publication-title: Cell
  doi: 10.1016/j.cell.2016.11.016
– volume: 23
  start-page: 672
  year: 2018
  ident: 7782_CR51
  publication-title: Cell. Host. Microbe
  doi: 10.1016/j.chom.2018.04.003
– volume: 44
  start-page: 39
  year: 2008
  ident: 7782_CR67
  publication-title: Methods
  doi: 10.1016/j.ymeth.2007.10.008
– volume: 44
  start-page: 3330
  year: 2016
  ident: 7782_CR40
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw061
– volume: 227
  start-page: 707
  year: 1996
  ident: 7782_CR57
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1996.1573
– volume: 287
  start-page: 21686
  year: 2012
  ident: 7782_CR50
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.328054
– volume: 9
  start-page: 357
  year: 2012
  ident: 7782_CR64
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 10
  start-page: e0004682
  year: 2016
  ident: 7782_CR23
  publication-title: PLoS. Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0004682
– volume: 10
  start-page: M900587MCP200
  year: 2011
  ident: 7782_CR49
  publication-title: Mol. Cell Proteom.
  doi: 10.1074/mcp.M900587-MCP200
– volume: 16
  start-page: 1107
  year: 2016
  ident: 7782_CR53
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(16)30320-6
– volume: 24
  start-page: 248
  year: 2018
  ident: 7782_CR26
  publication-title: Nat. Med.
  doi: 10.1038/nm0318-248
– volume: 21
  start-page: 6
  year: 2016
  ident: 7782_CR7
  publication-title: Eur. Surveill.
  doi: 10.2807/1560-7917.ES.2016.21.32.30314
– volume: 540
  start-page: 438
  year: 2016
  ident: 7782_CR18
  publication-title: Nature
  doi: 10.1038/nature20556
– volume: 75
  start-page: 8259
  year: 2001
  ident: 7782_CR60
  publication-title: J. Virol.
  doi: 10.1128/JVI.75.17.8259-8267.2001
– volume: 94
  start-page: 1362
  year: 2016
  ident: 7782_CR24
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.16-0111
– volume: 22
  start-page: 894
  year: 2008
  ident: 7782_CR39
  publication-title: Genes Dev.
  doi: 10.1101/gad.1640608
– volume: 8
  year: 2017
  ident: 7782_CR55
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00737-8
– volume: 22
  start-page: 1448
  year: 2016
  ident: 7782_CR15
  publication-title: Nat. Med.
  doi: 10.1038/nm.4206
– volume: 9
  start-page: 582
  year: 2008
  ident: 7782_CR37
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2008.74
– volume: 85
  start-page: 1464
  year: 2011
  ident: 7782_CR43
  publication-title: J. Virol.
  doi: 10.1128/JVI.02091-10
– ident: 7782_CR22
  doi: 10.1128/mBio.01114-16
– volume: 1
  year: 2014
  ident: 7782_CR36
  publication-title: Sci. Data
  doi: 10.1038/sdata.2014.5
– volume: 405
  start-page: 243
  year: 2010
  ident: 7782_CR58
  publication-title: Virology
  doi: 10.1016/j.virol.2010.06.014
– volume: 19
  start-page: 10
  year: 2006
  ident: 7782_CR42
  publication-title: Viral Immunol.
  doi: 10.1089/vim.2006.19.10
– volume: 66
  start-page: 1173
  year: 2018
  ident: 7782_CR12
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix967
– volume: 45
  start-page: 4142
  year: 2017
  ident: 7782_CR32
  publication-title: Nucleic Acids Res.
– volume: 378
  start-page: 1377
  year: 2018
  ident: 7782_CR11
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1711038
– volume: 188
  start-page: 904
  year: 2018
  ident: 7782_CR46
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2017.12.019
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Snippet Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract (MRT) poses new challenges for controlling virus outbreaks and...
The mechanisms of ZIKV persistence in the male reproductive tract (MRT) are poorly understood. Here, Tsetsarkin et al. applied microRNA-targeting approach to...
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SubjectTerms 14/63
38/109
38/90
49/98
631/326/590/1867
631/326/596/2557
631/326/596/2563
631/337/384/331
Animals
Brain
Chlorocebus aethiops
Disease Models, Animal
Disease transmission
Epididymis
Epididymis - virology
Epithelial cells
Genome, Viral - genetics
Genomes
Humanities and Social Sciences
Immunity
Immunodeficiency
Infectivity
Macaca mulatta
Male
Mice
MicroRNAs - genetics
miRNA
Monkeys
multidisciplinary
Organs
Outbreaks
Pathogenesis
Reproductive system
Ribonucleic acid
RNA
Science
Science (multidisciplinary)
Seminiferous Tubules - virology
Sexual transmission
Tropism
Tubules
Vaccines
Vector-borne diseases
Vero Cells
Viruses
Zika virus
Zika Virus - genetics
Zika Virus - immunology
Zika Virus - pathogenicity
Zika Virus Infection - pathology
Zika Virus Infection - transmission
Zika Virus Infection - veterinary
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Title Routes of Zika virus dissemination in the testis and epididymis of immunodeficient mice
URI https://link.springer.com/article/10.1038/s41467-018-07782-x
https://www.ncbi.nlm.nih.gov/pubmed/30559387
https://www.proquest.com/docview/2157865842
https://www.proquest.com/docview/2158247256
https://pubmed.ncbi.nlm.nih.gov/PMC6297220
https://doaj.org/article/ee7bfcbe055342979d1b86ee82672e3a
Volume 9
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