Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN

• Published in: Journal of autoimmunity Vol. 102; pp. 150 - 158
• Main Authors: Dieudonné, Yannick, Gies, Vincent, Guffroy, Aurélien, Keime, Céline, Bird, Anna K., Liesveld, Jane, Barnas, Jennifer L., Poindron, Vincent, Douiri, Nawal, Soulas-Sprauel, Pauline, Martin, Thierry, Meffre, Eric, Anolik, Jennifer H., Korganow, Anne-Sophie
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2019; Elsevier
• Subjects: CD19; Cellular Biology; Interferon; Life Sciences; Systemic lupus erythematosus; TLR9; Transitional B cells; TLR9; Interferon; Systemic lupus erythematosus; CD19; Transitional B cells

Systemic lupus (SLE) is characterized by a break of B cell tolerance that plays a central role in disease pathophysiology. An early checkpoint defect occurs at the transitional stage leading to the survival of autoreactive B cells and consequently the production of pathogenic autoantibodies. The mai...