Preventive effect of rebamipide on NSAID-induced lower gastrointestinal tract injury using FAERS and JADER

• Published in: Scientific reports Vol. 12; no. 1; p. 2631
• Main Authors: Imai, Toru, Hazama, Katsuyuki, Kosuge, Yasuhiro, Suzuki, Shinichiro, Ootsuka, Susumu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.02.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/575; 692/4020/2741/520; Adverse Drug Reaction Reporting Systems; Adverse events; Alanine - administration & dosage; Alanine - analogs & derivatives; Alanine - therapeutic use; Analgesics; Anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Clinical trials; Databases, Factual; Diclofenac; Diclofenac - administration & dosage; Diclofenac - therapeutic use; Drug Therapy, Combination; Gastrointestinal Diseases - chemically induced; Gastrointestinal Diseases - prevention & control; Gastrointestinal Tract; Humanities and Social Sciences; Humans; Inflammation; Japan; multidisciplinary; Nonsteroidal anti-inflammatory drugs; Phenylpropionates - administration & dosage; Phenylpropionates - therapeutic use; Prophylaxis; Quinolones - administration & dosage; Quinolones - therapeutic use; Science; Science (multidisciplinary); United States; United States Food and Drug Administration; United States; Japan

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for their antipyretic, analgesic, and anti-inflammatory properties. However, various aspects of NSAID-induced lower gastrointestinal tract injury remain unclear, and effective prophylaxis has not been established. Based on its pharmacolo...