β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway

• Published in: Communications biology Vol. 5; no. 1; pp. 519 - 15
• Main Authors: Zhou, Yingyu, Takano, Tomohiro, Li, Xuyang, Wang, Yimei, Wang, Rong, Zhu, Zhangliang, Tanokura, Masaru, Miyakawa, Takuya, Hachimura, Satoshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/21; 13/31; 13/95; 38; 38/39; 631/154/1435/2163; 692/699/1702/393; Adipose tissue; Animals; Ascites; Biology; Biomedical and Life Sciences; Body fat; Chronic illnesses; Cytokines; Cytokines - metabolism; Extracellular signal-regulated kinase; Gene expression; High fat diet; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Kinases; Life Sciences; Lipopolysaccharides; Macrophages; Macrophages - metabolism; MAP kinase; MAP Kinase Signaling System; Mice; Obesity; Obesity - drug therapy; Obesity - etiology; Obesity - metabolism; p38 Mitogen-Activated Protein Kinases - metabolism; Phenotypes; Phosphorylation; Protein kinase; Sesquiterpenes; Signal transduction

Macrophages are classified into classically activated M1 macrophages and alternatively activated M2 macrophages, and the two phenotypes of macrophages are present during the development of various chronic diseases, including obesity-induced inflammation. In the present study, β-elemene, which is con...