The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

• Published in: Inflammation research Vol. 68; no. 11; pp. 915 - 932
• Main Authors: Korbecki, Jan, Bajdak-Rusinek, Karolina
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2019; Springer Nature B.V
• Subjects: Activation; Allergology; Animals; Baby foods; Biomedical and Life Sciences; Biomedicine; Blood levels; Cytokines; Dermatology; Diglycerides; Fatty Acid-Binding Proteins - metabolism; Fatty acids; Humans; IL-1β; Immune system; Immunology; Inflammasomes; Inflammation; Inflammatory response; Insulin; Insulin resistance; Interleukin 6; Lipopolysaccharides; Macrophages; Macrophages - metabolism; Metabolic rate; Molecular modelling; Neurology; NF-κB protein; Obesity - metabolism; Palmitic acid; Palmitic Acid - metabolism; Pharmacology/Toxicology; Phospholipids; PPAR gamma - metabolism; Protein kinase C; Proteins; Receptors; Review; Rheumatology; Signaling; TLR2 protein; TLR4 protein; Toll-like receptors; Toll-Like Receptors - metabolism; Tumor necrosis factor-α; Obesity; Insulin resistance; Inflammation; Palmitic acid; Saturated fatty acid; Macrophage

Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and TLR4, play an important role. Nevertheless, palmitic acid is not only a TLR agonist. In the cell, this fatty acid is converte...