The updated landscape of tumor microenvironment and drug repurposing

• Published in: Signal transduction and targeted therapy Vol. 5; no. 1; p. 166
• Main Authors: Jin, Ming-Zhu, Jin, Wei-Lin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.08.2020; Nature Publishing Group
• Subjects: 631/67/327; 692/308/575; 692/4028/67/327; Antidiabetics; Cancer Research; Cancer therapies; Cell Biology; Drug Repositioning; Humans; Internal Medicine; Medicine; Medicine & Public Health; Metformin - therapeutic use; Molecular Targeted Therapy; Neoplasms - drug therapy; Neoplasms - genetics; Oncology; Pathology; Review; Review Article; Tumor Microenvironment - drug effects; Tumor Microenvironment - genetics

Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies. Cancer research and treatment have switched from a cancer-centric model to a TME-centric one, considering the in...