SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response

• Published in: Cellular & molecular immunology Vol. 18; no. 3; pp. 613 - 620
• Main Authors: Fu, Yu-Zhi, Wang, Su-Yun, Zheng, Zhou-Qin, Yi Huang, Li, Wei-Wei, Xu, Zhi-Sheng, Wang, Yan-Yi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2021; Nature Publishing Group
• Subjects: 631/250/2161; 631/250/262; Adaptor Proteins, Signal Transducing - immunology; Antibodies; Antiviral drugs; Biomedical and Life Sciences; Biomedicine; Coronaviruses; COVID-19 - immunology; Glycoproteins; HEK293 Cells; HeLa Cells; Humans; Immune response; Immunity, Innate; Immunology; Innate immunity; Interferon regulatory factor 3; M protein; Medical Microbiology; Microbiology; Morbidity; Proteins; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Signal Transduction - immunology; Vaccine; Viral Matrix Proteins - immunology; Innate immunity; SARS-CoV-2; Membrane glycoprotein M; MAVS; Type I interferon

A novel SARS-related coronavirus (SARS-CoV-2) has recently emerged as a serious pathogen that causes high morbidity and substantial mortality. However, the mechanisms by which SARS-CoV-2 evades host immunity remain poorly understood. Here, we identified SARS-CoV-2 membrane glycoprotein M as a negati...