PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments

• Published in: Nature communications Vol. 10; no. 1; pp. 2950 - 18
• Main Authors: Wang, Chen-Yu, Colognori, David, Sunwoo, Hongjae, Wang, Danni, Lee, Jeannie T.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.07.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 38; 38/32; 38/71; 45; 45/15; 45/23; 45/41; 45/70; 45/91; 631/114/2785; 631/208/176/1433; 631/337/103; Ablation; Activation; Animals; Chromosomal Proteins, Non-Histone - metabolism; Chromosomes; Chromosomes, Mammalian - genetics; Compartments; Deactivation; Deoxyribonucleic acid; Depletion; DNA; DNA methylation; DNA Methylation - genetics; Histones - metabolism; Humanities and Social Sciences; Inactivation; Lysine - metabolism; Mice; Models, Genetic; multidisciplinary; Partitions; Polycomb group proteins; Polycomb Repressive Complex 1 - metabolism; Ribonucleic acid; RNA; RNA, Long Noncoding - metabolism; Science; Science (multidisciplinary); Self-association; Spreading; X Chromosome - chemistry; X Chromosome - genetics; X Chromosome Inactivation - genetics; X chromosomes; X-chromosome inactivation

X-chromosome inactivation triggers fusion of A/B compartments to inactive X (Xi)-specific structures known as S1 and S2 compartments. SMCHD1 then merges S1/S2s to form the Xi super-structure. Here, we ask how S1/S2 compartments form and reveal that Xist RNA drives their formation via recruitment of...