Involvement of the habenula in the pathophysiology of autism spectrum disorder

The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory integration and circadian rhythm. Auti...

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Published inScientific reports Vol. 11; no. 1; p. 21168
Main Authors Germann, Jürgen, Gouveia, Flavia Venetucci, Brentani, Helena, Bedford, Saashi A., Tullo, Stephanie, Chakravarty, M. Mallar, Devenyi, Gabriel A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 27.10.2021
Nature Publishing Group
Nature Portfolio
Subjects
631/378/1689/1373
631/378/3919
692/698/1688/64
Adolescent
Adult
Autism
Autism Spectrum Disorder - diagnostic imaging
Autism Spectrum Disorder - pathology
Brain stem
Child
Circadian rhythms
Female
Habenula
Habenula - diagnostic imaging
Habenula - pathology
Humanities and Social Sciences
Humans
Image processing
Magnetic Resonance Imaging
Male
multidisciplinary
Pathophysiology
Reinforcement
Science
Science (multidisciplinary)
Segmentation
Sensory integration
Sleep disorders
Social Behavior
Social interactions
Support Vector Machine
Online AccessGet full text

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Abstract The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory integration and circadian rhythm. Autism spectrum disorder (ASD) is characterized by social communication deficits, restricted interests, repetitive behaviors, and is frequently associated with altered sensory perception and mood and sleep disorders. The habenula is implicated in all these behaviors and results of preclinical studies suggest a possible involvement of the habenula in the pathophysiology of this disorder. Using anatomical magnetic resonance imaging and automated segmentation we show that the habenula is significantly enlarged in ASD subjects compared to controls across the entire age range studied (6–30 years). No differences were observed between sexes. Furthermore, support-vector machine modeling classified ASD with 85% accuracy (model using habenula volume, age and sex) and 64% accuracy in cross validation. The Social Responsiveness Scale (SRS) significantly differed between groups, however, it was not related to individual habenula volume. The present study is the first to provide evidence in human subjects of an involvement of the habenula in the pathophysiology of ASD.
AbstractList The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory integration and circadian rhythm. Autism spectrum disorder (ASD) is characterized by social communication deficits, restricted interests, repetitive behaviors, and is frequently associated with altered sensory perception and mood and sleep disorders. The habenula is implicated in all these behaviors and results of preclinical studies suggest a possible involvement of the habenula in the pathophysiology of this disorder. Using anatomical magnetic resonance imaging and automated segmentation we show that the habenula is significantly enlarged in ASD subjects compared to controls across the entire age range studied (6–30 years). No differences were observed between sexes. Furthermore, support-vector machine modeling classified ASD with 85% accuracy (model using habenula volume, age and sex) and 64% accuracy in cross validation. The Social Responsiveness Scale (SRS) significantly differed between groups, however, it was not related to individual habenula volume. The present study is the first to provide evidence in human subjects of an involvement of the habenula in the pathophysiology of ASD.
The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory integration and circadian rhythm. Autism spectrum disorder (ASD) is characterized by social communication deficits, restricted interests, repetitive behaviors, and is frequently associated with altered sensory perception and mood and sleep disorders. The habenula is implicated in all these behaviors and results of preclinical studies suggest a possible involvement of the habenula in the pathophysiology of this disorder. Using anatomical magnetic resonance imaging and automated segmentation we show that the habenula is significantly enlarged in ASD subjects compared to controls across the entire age range studied (6–30 years). No differences were observed between sexes. Furthermore, support-vector machine modeling classified ASD with 85% accuracy (model using habenula volume, age and sex) and 64% accuracy in cross validation. The Social Responsiveness Scale (SRS) significantly differed between groups, however, it was not related to individual habenula volume. The present study is the first to provide evidence in human subjects of an involvement of the habenula in the pathophysiology of ASD.
Abstract The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory integration and circadian rhythm. Autism spectrum disorder (ASD) is characterized by social communication deficits, restricted interests, repetitive behaviors, and is frequently associated with altered sensory perception and mood and sleep disorders. The habenula is implicated in all these behaviors and results of preclinical studies suggest a possible involvement of the habenula in the pathophysiology of this disorder. Using anatomical magnetic resonance imaging and automated segmentation we show that the habenula is significantly enlarged in ASD subjects compared to controls across the entire age range studied (6–30 years). No differences were observed between sexes. Furthermore, support-vector machine modeling classified ASD with 85% accuracy (model using habenula volume, age and sex) and 64% accuracy in cross validation. The Social Responsiveness Scale (SRS) significantly differed between groups, however, it was not related to individual habenula volume. The present study is the first to provide evidence in human subjects of an involvement of the habenula in the pathophysiology of ASD.
Abstract The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory integration and circadian rhythm. Autism spectrum disorder (ASD) is characterized by social communication deficits, restricted interests, repetitive behaviors, and is frequently associated with altered sensory perception and mood and sleep disorders. The habenula is implicated in all these behaviors and results of preclinical studies suggest a possible involvement of the habenula in the pathophysiology of this disorder. Using anatomical magnetic resonance imaging and automated segmentation we show that the habenula is significantly enlarged in ASD subjects compared to controls across the entire age range studied (6–30 years). No differences were observed between sexes. Furthermore, support-vector machine modeling classified ASD with 85% accuracy (model using habenula volume, age and sex) and 64% accuracy in cross validation. The Social Responsiveness Scale (SRS) significantly differed between groups, however, it was not related to individual habenula volume. The present study is the first to provide evidence in human subjects of an involvement of the habenula in the pathophysiology of ASD.
ArticleNumber 21168
Author Brentani, Helena
Tullo, Stephanie
Germann, Jürgen
Chakravarty, M. Mallar
Gouveia, Flavia Venetucci
Devenyi, Gabriel A.
Bedford, Saashi A.
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  surname: Germann
  fullname: Germann, Jürgen
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  givenname: Flavia Venetucci
  surname: Gouveia
  fullname: Gouveia, Flavia Venetucci
  organization: Neuroscience and Mental Health, Hospital for Sick Children Research Institute
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  givenname: Helena
  surname: Brentani
  fullname: Brentani, Helena
  organization: Department of Psychiatry, University of Sao Paulo, Medical School, National Institute of Developmental Psychiatry for Children and Adolescents, CNPq
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  givenname: Saashi A.
  surname: Bedford
  fullname: Bedford, Saashi A.
  organization: Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Autism Research Centre, Department of Psychiatry, University of Cambridge
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  givenname: M. Mallar
  surname: Chakravarty
  fullname: Chakravarty, M. Mallar
  organization: Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Department of Biomedical Engineering, McGill University, Department of Psychiatry, McGill University
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  givenname: Gabriel A.
  surname: Devenyi
  fullname: Devenyi, Gabriel A.
  organization: Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Department of Psychiatry, McGill University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34707133$$D View this record in MEDLINE/PubMed
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SSID ssj0000529419
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Snippet The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as...
Abstract The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been...
Abstract The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been...
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SubjectTerms 631/378/1689/1373
631/378/3919
692/698/1688/64
Adolescent
Adult
Autism
Autism Spectrum Disorder - diagnostic imaging
Autism Spectrum Disorder - pathology
Brain stem
Child
Circadian rhythms
Female
Habenula
Habenula - diagnostic imaging
Habenula - pathology
Humanities and Social Sciences
Humans
Image processing
Magnetic Resonance Imaging
Male
multidisciplinary
Pathophysiology
Reinforcement
Science
Science (multidisciplinary)
Segmentation
Sensory integration
Sleep disorders
Social Behavior
Social interactions
Support Vector Machine
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Title Involvement of the habenula in the pathophysiology of autism spectrum disorder
URI https://link.springer.com/article/10.1038/s41598-021-00603-0
https://www.ncbi.nlm.nih.gov/pubmed/34707133
https://www.proquest.com/docview/2586674315
https://search.proquest.com/docview/2587764324
https://pubmed.ncbi.nlm.nih.gov/PMC8551275
https://doaj.org/article/b2c2ce2d90cc4e10a9165610e25248ca
Volume 11
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