PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome

• Published in: Nature communications Vol. 11; no. 1; pp. 6354 - 12
• Main Authors: Meng, Tie-Gang, Zhou, Qian, Ma, Xue-Shan, Liu, Xiao-Yu, Meng, Qing-Ren, Huang, Xian-Ju, Liu, Hong-Lin, Lei, Wen-Long, Zhao, Zheng-Hui, Ouyang, Ying-Chun, Hou, Yi, Schatten, Heide, Ou, Xiang-Hong, Wang, Zhen-Bo, Gao, Shao-Rong, Sun, Qing-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.12.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 14/19; 38/89; 631/136/2434/1706; 631/208/176; 631/337/100/2285; 64/60; 82/80; Animals; Enhancer of Zeste Homolog 2 Protein - genetics; Enhancer of Zeste Homolog 2 Protein - metabolism; Epigenetics; Epigenomics; Eukaryotes; Gene silencing; Genome; Genomes; Heterochromatin; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Histones - metabolism; Humanities and Social Sciences; Male; Mammals; Methylation; Mice; Mice, Inbred ICR; Mice, Knockout; Micrococcal Nuclease; multidisciplinary; Nuclease; Oogenesis - physiology; Polycomb Repressive Complex 2 - genetics; Pronucleus; Protein Processing, Post-Translational; Regulatory mechanisms (biology); Science; Science (multidisciplinary); Zygote - metabolism; Zygotes

The formation of zygote is the beginning of mammalian life, and dynamic epigenetic modifications are essential for mammalian normal development. H3K27 di-methylation (H3K27me2) and H3K27 tri-methylation (H3K27me3) are marks of facultative heterochromatin which maintains transcriptional repression es...