Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis

• Published in: European radiology Vol. 31; no. 11; pp. 8408 - 8419
• Main Authors: Qu, Yali, Middleton, Michael S., Loomba, Rohit, Glaser, Kevin J., Chen, Jun, Hooker, Jonathan C., Wolfson, Tanya, Covarrubias, Yesenia, Valasek, Mark A., Fowler, Kathryn J., Zhang, Yingzhen N., Sy, Ethan, Gamst, Anthony C., Wang, Kang, Mamidipalli, Adrija, Schwimmer, Jeffrey B., Song, Bin, Reeder, Scott B., Yin, Meng, Ehman, Richard L., Sirlin, Claude B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2021; Springer Nature B.V
• Subjects: Adults; Age; Biomarkers; Biopsy; Damping ratio; Diagnostic Radiology; Elasticity Imaging Techniques; Fatty liver; Fibrosis; Histology; Humans; Imaging; Inflammation; Internal Medicine; Interventional Radiology; Liver; Liver - diagnostic imaging; Liver - pathology; Liver Cirrhosis - diagnostic imaging; Liver Cirrhosis - pathology; Liver diseases; Loss modulus; Magnetic properties; Magnetic Resonance; Magnetic Resonance Imaging; Mechanical properties; Medicine; Medicine & Public Health; Neuroradiology; Non-alcoholic Fatty Liver Disease - diagnostic imaging; Non-alcoholic Fatty Liver Disease - pathology; Prospective Studies; Proton density (concentration); Radiology; Resonance; Retrospective Studies; Shear stiffness; Storage modulus; Ultrasound; Wave attenuation; Nonalcoholic fatty liver disease; Inflammation; Magnetic resonance imaging; Elasticity imaging techniques

Objectives To investigate associations between histology and hepatic mechanical properties measured using multiparametric magnetic resonance elastography (MRE) in adults with known or suspected nonalcoholic fatty liver disease (NAFLD) without histologic fibrosis. Methods This was a retrospective ana...