HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia

• Published in: Nature communications Vol. 12; no. 1; pp. 1956 - 17
• Main Authors: Zhu, Ganqian, Luo, Huacheng, Feng, Yang, Guryanova, Olga A., Xu, Jianfeng, Chen, Shi, Lai, Qian, Sharma, Arati, Xu, Bing, Zhao, Zhigang, Feng, Ru, Ni, Hongyu, Claxton, David, Guo, Ying, Mesa, Ruben A., Qiu, Yi, Yang, Feng-Chun, Li, Wei, Nimer, Stephen D., Huang, Suming, Xu, Mingjiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 42; 42/100; 42/109; 42/34; 42/40; 42/89; 45/15; 45/22; 45/77; 45/90; 45/91; 631/136/2441; 631/67/1990/283/1897; 631/67/70; 64; 64/110; 64/60; 692/308/2171; Acute myeloid leukemia; Animals; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Cell Line, Tumor; Cell Proliferation; Chromatin; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Heterografts; Histone-Lysine N-Methyltransferase - genetics; Histone-Lysine N-Methyltransferase - metabolism; Histones - genetics; Histones - metabolism; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Humanities and Social Sciences; Humans; Leukemia; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Acute - pathology; Leukemogenesis; Loci; Mice; Mice, Transgenic; multidisciplinary; Multigene Family; Mutants; Mutation; Myeloid Ecotropic Viral Integration Site 1 Protein - genetics; Myeloid Ecotropic Viral Integration Site 1 Protein - metabolism; Myeloid leukemia; Myeloid-Lymphoid Leukemia Protein - genetics; Myeloid-Lymphoid Leukemia Protein - metabolism; Myelopoiesis; Myelopoiesis - genetics; Non-coding RNA; Nuclear Proteins - deficiency; Nuclear Proteins - genetics; Nucleoli; Phenotypes; Point mutation; Promoter Regions, Genetic; Ribonucleic acid; RNA; RNA, Long Noncoding - agonists; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Science; Science (multidisciplinary); Signal Transduction; Therapeutic targets; Transcription activation; Transcription, Genetic; Transcriptomes; Translocation

Nucleophosmin ( NPM1 ) is the most commonly mutated gene in acute myeloid leukemia (AML) resulting in aberrant cytoplasmic translocation of the encoded nucleolar protein (NPM1c + ). NPM1c + maintains a unique leukemic gene expression program, characterized by activation of HOXA / B clusters and MEIS...