Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19

• Published in: Scientific reports Vol. 11; no. 1; pp. 13308 - 13
• Main Authors: Britton, Graham J., Chen-Liaw, Alice, Cossarini, Francesca, Livanos, Alexandra E., Spindler, Matthew P., Plitt, Tamar, Eggers, Joseph, Mogno, Ilaria, Gonzalez-Reiche, Ana S., Siu, Sophia, Tankelevich, Michael, Grinspan, Lauren Tal, Dixon, Rebekah E., Jha, Divya, van de Guchte, Adriana, Khan, Zenab, Martinez-Delgado, Gustavo, Amanat, Fatima, Hoagland, Daisy A., tenOever, Benjamin R., Dubinsky, Marla C., Merad, Miriam, van Bakel, Harm, Krammer, Florian, Bongers, Gerold, Mehandru, Saurabh, Faith, Jeremiah J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/254; 631/250/256; 631/250/347; 631/326/596/4130; 692/308/575; 692/4020/1503/1581; Aged; Biomarkers - metabolism; Biopsy; Cohort Studies; Coronaviruses; COVID-19; COVID-19 - epidemiology; COVID-19 - immunology; Cytokines - metabolism; Diarrhea; Feces; Feces - virology; Female; Gastrointestinal Microbiome; Gastrointestinal tract; Humanities and Social Sciences; Humans; Humerus; Immune response; Immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin A - immunology; Inflammation; Interleukin 10; Interleukin 23; Interleukin 8; Intestine; Male; Microbiomes; Middle Aged; multidisciplinary; Nasopharynx; Nasopharynx - virology; New York City - epidemiology; Ribonucleic acid; RNA; RNA, Viral - isolation & purification; SARS-CoV-2 - isolation & purification; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; New York City

Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers...