Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19

Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers...

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Published inScientific reports Vol. 11; no. 1; pp. 13308 - 13
Main Authors Britton, Graham J., Chen-Liaw, Alice, Cossarini, Francesca, Livanos, Alexandra E., Spindler, Matthew P., Plitt, Tamar, Eggers, Joseph, Mogno, Ilaria, Gonzalez-Reiche, Ana S., Siu, Sophia, Tankelevich, Michael, Grinspan, Lauren Tal, Dixon, Rebekah E., Jha, Divya, van de Guchte, Adriana, Khan, Zenab, Martinez-Delgado, Gustavo, Amanat, Fatima, Hoagland, Daisy A., tenOever, Benjamin R., Dubinsky, Marla C., Merad, Miriam, van Bakel, Harm, Krammer, Florian, Bongers, Gerold, Mehandru, Saurabh, Faith, Jeremiah J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 25.06.2021
Nature Publishing Group
Nature Portfolio
Subjects
631/250/254
631/250/256
631/250/347
631/326/596/4130
692/308/575
692/4020/1503/1581
Aged
Biomarkers - metabolism
Biopsy
Cohort Studies
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - immunology
Cytokines - metabolism
Diarrhea
Feces
Feces - virology
Female
Gastrointestinal Microbiome
Gastrointestinal tract
Humanities and Social Sciences
Humans
Humerus
Immune response
Immunoglobulin A
Immunoglobulin A - blood
Immunoglobulin A - immunology
Inflammation
Interleukin 10
Interleukin 23
Interleukin 8
Intestine
Male
Microbiomes
Middle Aged
multidisciplinary
Nasopharynx
Nasopharynx - virology
New York City - epidemiology
Ribonucleic acid
RNA
RNA, Viral - isolation & purification
SARS-CoV-2 - isolation & purification
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
New York City
Online AccessGet full text

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Abstract Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.
AbstractList Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.
Abstract Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.
Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of tissue samples, we measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.
ArticleNumber 13308
Author Cossarini, Francesca
Krammer, Florian
Amanat, Fatima
Siu, Sophia
Hoagland, Daisy A.
Faith, Jeremiah J.
van de Guchte, Adriana
Khan, Zenab
Jha, Divya
tenOever, Benjamin R.
Grinspan, Lauren Tal
van Bakel, Harm
Spindler, Matthew P.
Martinez-Delgado, Gustavo
Tankelevich, Michael
Bongers, Gerold
Gonzalez-Reiche, Ana S.
Chen-Liaw, Alice
Plitt, Tamar
Dubinsky, Marla C.
Merad, Miriam
Britton, Graham J.
Mehandru, Saurabh
Eggers, Joseph
Mogno, Ilaria
Dixon, Rebekah E.
Livanos, Alexandra E.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34172783$$D View this record in MEDLINE/PubMed
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Snippet Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to...
Abstract Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly...
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Aged
Biomarkers - metabolism
Biopsy
Cohort Studies
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - immunology
Cytokines - metabolism
Diarrhea
Feces
Feces - virology
Female
Gastrointestinal Microbiome
Gastrointestinal tract
Humanities and Social Sciences
Humans
Humerus
Immune response
Immunoglobulin A
Immunoglobulin A - blood
Immunoglobulin A - immunology
Inflammation
Interleukin 10
Interleukin 23
Interleukin 8
Intestine
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Microbiomes
Middle Aged
multidisciplinary
Nasopharynx
Nasopharynx - virology
New York City - epidemiology
Ribonucleic acid
RNA
RNA, Viral - isolation & purification
SARS-CoV-2 - isolation & purification
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
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Title Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19
URI https://link.springer.com/article/10.1038/s41598-021-92740-9
https://www.ncbi.nlm.nih.gov/pubmed/34172783
https://www.proquest.com/docview/2544995852
https://www.proquest.com/docview/2545598112
https://pubmed.ncbi.nlm.nih.gov/PMC8233421
https://doaj.org/article/d6c31edc6052419cbb41e75506d8cb06
Volume 11
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