Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins

• Published in: Communications biology Vol. 4; no. 1; p. 642
• Main Authors: Robeck, Todd R., Fei, Zhe, Lu, Ake T., Haghani, Amin, Jourdain, Eve, Zoller, Joseph A., Li, Caesar Z., Steinman, Karen J., DiRocco, Stacy, Schmitt, Todd, Osborn, Steve, Van Bonn, Bill, Katsumata, Etsuko, Mergl, June, Almunia, Javier, Rodriguez, Magdalena, Haulena, Martin, Dold, Christopher, Horvath, Steve
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 45/43; 631/158/672; 631/208/176/1988; Age; Age determination; Age Factors; Aging; Aging - genetics; Aging - physiology; Animals; Biology; Biomedical and Life Sciences; Cetacea; CpG islands; Deoxyribonucleic acid; DNA; DNA - genetics; DNA fingerprinting; DNA methylation; DNA Methylation - genetics; Dolphins & porpoises; Dolphins - genetics; Dolphins - metabolism; Epigenesis, Genetic - genetics; Epigenetics; Epigenomics - methods; Genome; Genomes; Life Sciences; Odontoceti; Phylogeny; Skin; Species; Whales - genetics; Whales - metabolism; Wildlife conservation

The development of a precise blood or skin tissue DNA Epigenetic Aging Clock for Odontocete (OEAC) would solve current age estimation inaccuracies for wild odontocetes. Therefore, we determined genome-wide DNA methylation profiles using a custom array (HorvathMammalMethyl40) across skin and blood sa...