JNK regulates muscle remodeling via myostatin/SMAD inhibition

• Published in: Nature communications Vol. 9; no. 1; pp. 3030 - 14
• Main Authors: Lessard, Sarah J., MacDonald, Tara L., Pathak, Prerana, Han, Myoung Sook, Coffey, Vernon G., Edge, Johann, Rivas, Donato A., Hirshman, Michael F., Davis, Roger J., Goodyear, Laurie J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.08.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/106; 13/109; 13/95; 14; 14/34; 14/63; 38; 38/77; 631/80/86; 692/698/1671/1668; Adult; Animals; c-Jun protein; Cardiorespiratory fitness; Cell Nucleus - metabolism; Durability; Endurance; Enzyme Activation; Exercise; Fitness; Gene Expression Regulation; HEK293 Cells; Humanities and Social Sciences; Humans; Hypertrophy; Integrases - metabolism; JNK Mitogen-Activated Protein Kinases - metabolism; JNK protein; Mice, Inbred C57BL; Mice, Knockout; Molecular machines; multidisciplinary; Muscle Development; Muscle, Skeletal - metabolism; Muscle, Skeletal - pathology; Muscles; Muscles - metabolism; Musculoskeletal system; Myostatin; Myostatin - metabolism; Oxidation resistance; Phosphorylation; Physical Conditioning, Animal; Physical Endurance; Physical exercise; Protein Transport; Science; Science (multidisciplinary); Signal Transduction; Signaling; Skeletal muscle; Smad protein; Smad Proteins - antagonists & inhibitors; Smad Proteins - metabolism; Smad2 protein; Transcription factors

Skeletal muscle has a remarkable plasticity to adapt and remodel in response to environmental cues, such as physical exercise. Endurance exercise stimulates improvements in muscle oxidative capacity, while resistance exercise induces muscle growth. Here we show that the c-Jun N-terminal kinase (JNK)...