The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

• Published in: Endocrinology (Philadelphia) Vol. 153; no. 8; pp. 3613 - 3619
• Main Authors: Pournaras, Dimitri J., Glicksman, Clare, Vincent, Royce P., Kuganolipava, Shophia, Alaghband-Zadeh, Jamie, Mahon, David, Bekker, Jan H.R., Ghatei, Mohammad A., Bloom, Stephen R., Walters, Julian R.F., Welbourn, Richard, le Roux, Carel W.
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Oxford University Press 01.08.2012; Endocrine Society
• Subjects: Acids; Adult; Animal models; Animals; Bile; Bile - physiology; Bile acids; Bile Acids and Salts - blood; Biological and medical sciences; Blood Glucose - metabolism; Body weight; C-Reactive Protein; Calorimetry; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diabetes-Insulin-Glucagon-Gastrointestinal; Dogs; Female; Fibroblast Growth Factors - blood; Food intake; Fundamental and applied biological sciences. Psychology; Gastric Bypass; Gastrointestinal surgery; Glucagon-Like Peptide 1 - blood; Growth factors; Humans; Ileum; Male; Middle Aged; Peptide YY - blood; Plasma; Rats; Rats, Wistar; Remission; Satiety; Small intestine; Vertebrates: endocrinology; Weight; Weight loss; Weight Loss - physiology; Biological fluid; Stomach; Digestive system; Bile

Gastric bypass leads to the remission of type 2 diabetes independently of weight loss. Our hypothesis is that changes in bile flow due to the altered anatomy may partly explain the metabolic outcomes of the operation. We prospectively studied 12 patients undergoing gastric bypass and six patients un...