Sample composition alters associations between age and brain structure

• Published in: Nature communications Vol. 8; no. 1; pp. 874 - 14
• Main Authors: LeWinn, Kaja Z., Sheridan, Margaret A., Keyes, Katherine M., Hamilton, Ava, McLaughlin, Katie A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.10.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2571; 706/689; Age; Age composition; Brain; Children; Communities; Cortex; Humanities and Social Sciences; Maturation; Medical imaging; Minority & ethnic groups; multidisciplinary; Neuroimaging; Neurology; Science; Science (multidisciplinary); Socioeconomics; Substantia grisea

Despite calls to incorporate population science into neuroimaging research, most studies recruit small, non-representative samples. Here, we examine whether sample composition influences age-related variation in global measurements of gray matter volume, thickness, and surface area. We apply sample...