Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment

• Published in: Nature communications Vol. 12; no. 1; pp. 7335 - 15
• Main Authors: Dinh, Huy Q., Pan, Feng, Wang, Geng, Huang, Qing-Feng, Olingy, Claire E., Wu, Zhi-Yong, Wang, Shao-Hong, Xu, Xin, Xu, Xiu-E, He, Jian-Zhong, Yang, Qian, Orsulic, Sandra, Haro, Marcela, Li, Li-Yan, Huang, Guo-Wei, Breunig, Joshua J., Koeffler, H. Phillip, Hedrick, Catherine C., Xu, Li-Yan, Lin, De-Chen, Li, En-Min
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 38/91; 631/337/2019; 631/67/1504/1477; 631/67/2329; 631/67/327; 631/67/69; Antigen Presentation; Antigens; Biology; Biomarkers, Tumor - metabolism; Cancer; Dendritic Cells - metabolism; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - immunology; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - immunology; Esophageal Squamous Cell Carcinoma - pathology; Esophagus; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heterogeneity; Histocompatibility Antigens Class II - metabolism; Humanities and Social Sciences; Humans; Immune checkpoint inhibitors; Immune system; Immunosuppression; Impact response; multidisciplinary; Myeloid Cells - metabolism; Myofibroblasts - pathology; Prognosis; Salivary Cystatins - metabolism; Science; Science (multidisciplinary); Single-Cell Analysis; Squamous cell carcinoma; Survival Analysis; T-Lymphocytes - metabolism; Transcriptomes; Tumor microenvironment; Tumor Microenvironment - genetics; Tumor Microenvironment - immunology; Tumors

The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we analyze the microenvironment of esophageal squamous cell carcinoma (ESCC) using single-cell transcriptome sequencing in 62,161 cells from bloo...