Cobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne

• Published in: Nature communications Vol. 9; no. 1; pp. 798 - 7
• Main Authors: Tang, Shan, Wang, Dan, Liu, Yichang, Zeng, Li, Lei, Aiwen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.02.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/934; 639/638/549/933; 639/638/77/886; Amides; Aromatic compounds; Carbon; Chemical reactions; Chemicals; Cobalt; Dehydrogenation; Efficiency; Electrochemistry; Ethylene; Fine chemicals; Functional groups; Humanities and Social Sciences; multidisciplinary; Organic chemistry; Oxidants; Oxidation; Oxidizing agents; Recycling; Science; Science (multidisciplinary)

Ethylene and ethyne are among the simplest two-carbon building blocks. However, quite limited methods can be applied to incorporate ethylene or ethyne into fine chemicals. Here we demonstrate a cobalt-catalyzed dehydrogenative C–H/N–H [4+2] annulation of aryl/vinyl amides with ethylene or ethyne by...