Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain

• Published in: Nature communications Vol. 11; no. 1; p. 5919
• Main Authors: Serramito-Gómez, Inmaculada, Boada-Romero, Emilio, Villamuera, Raquel, Fernández-Cabrera, Álvaro, Cedillo, José Luis, Martín-Regalado, Ángela, Carding, Simon, Mayer, Uli, Powell, Penny P., Wileman, Thomas, García-Higuera, Irene, Pimentel-Muiños, Felipe X.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.11.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/21; 13/95; 14; 14/19; 38/77; 631/250/127/1213; 631/80/39/2346; 631/80/86; 82/75; 82/79; 96/95; Amino acids; Autophagy; Autophagy - physiology; Autophagy-Related Proteins - metabolism; Binding; Carrier Proteins - metabolism; Cytokine receptors; Cytokines; Cytokines - chemistry; Cytokines - metabolism; Domains; Endocytosis; Endocytosis - physiology; Humanities and Social Sciences; Humans; Interleukin 1; Interleukin 10; Interleukin 2 receptors; Interleukin-10 - metabolism; Intracellular; Intracellular signalling; Microtubule-Associated Proteins - metabolism; multidisciplinary; Peptide libraries; Phagocytosis; Protein Transport; Receptors; Receptors, Cytokine - metabolism; Receptors, Interleukin-10 - metabolism; Science; Science (multidisciplinary); Signal Transduction - physiology; Signaling; WD40 Repeats

ATG16L1, an autophagy mediator that specifies the site of LC3 lipidation, includes a C-terminal domain formed by 7 WD40-type repeats (WD40 domain, WDD), the function of which is unclear. Here we show that the WDD interacts with the intracellular domain of cytokine receptors to regulate their signali...