Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke

The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon...

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Published inNature communications Vol. 13; no. 1; p. 7812
Main Authors Li, Wenlu, Mandeville, Emiri T., Durán-Laforet, Violeta, Fukuda, Norito, Yu, Zhanyang, Zheng, Yi, Held, Aaron, Park, Ji-Hyun, Nakano, Takafumi, Tanaka, Masayoshi, Shi, Jingfei, Esposito, Elga, Niu, Wanting, Xing, Changhong, Hayakawa, Kazuhide, Lizasoain, Ignacio, van Leyen, Klaus, Ji, Xunming, Wainger, Brian J., Moro, Maria A., Lo, Eng H.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.12.2022
Nature Publishing Group
Nature Portfolio
Subjects
14/28
631/378/2596/1308
631/378/2607
692/699/375/534
Animal models
Animals
ASCL1 protein
Astrocytes
Brain
Brain damage
Cell differentiation
Cell signaling
Cell Transdifferentiation
Cells, Cultured
Conversion
Deprivation
Differentiation
Endothelial Cells
Endothelium
Glucose
Humanities and Social Sciences
Ischemia
Male
Mice
multidisciplinary
Neural plasticity
Neural Stem Cells
Neurogenesis
Neuronal-glial interactions
Oxygen
Progenitor cells
Science
Science (multidisciplinary)
Stroke
Online AccessGet full text

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Abstract The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke. Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural progenitors, thus improving outcomes after stroke.
AbstractList The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke.Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural progenitors, thus improving outcomes after stroke.
The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke.
Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural progenitors, thus improving outcomes after stroke.
Abstract The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke.
The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke. Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural progenitors, thus improving outcomes after stroke.
ArticleNumber 7812
Author Moro, Maria A.
van Leyen, Klaus
Ji, Xunming
Mandeville, Emiri T.
Zheng, Yi
Held, Aaron
Tanaka, Masayoshi
Hayakawa, Kazuhide
Durán-Laforet, Violeta
Li, Wenlu
Shi, Jingfei
Niu, Wanting
Fukuda, Norito
Xing, Changhong
Lo, Eng H.
Park, Ji-Hyun
Wainger, Brian J.
Lizasoain, Ignacio
Yu, Zhanyang
Nakano, Takafumi
Esposito, Elga
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36535938$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1152/physrev.00050.2017
10.1038/s41586-020-2388-4
10.1016/S1474-4422(12)70039-X
10.1126/science.1095505
10.1038/nm.4188
10.1016/j.stem.2015.07.002
10.1016/j.cell.2020.03.024
10.1038/nprot.2009.125
10.1038/s41593-021-00904-7
10.1016/j.conb.2018.11.004
10.1002/glia.20374
10.1016/j.pneurobio.2015.09.008
10.1177/0271678X20910324
10.1021/acsnano.7b08297
10.1038/nature12354
10.1016/j.celrep.2013.06.035
10.1073/pnas.1811825116
10.1016/j.pneurobio.2016.04.004
10.1186/s13041-016-0243-1
10.1038/ncomms3373
10.1016/S0165-3806(01)00286-3
10.1186/1471-213X-1-4
10.1177/0271678X21992980
10.1038/s41582-018-0126-4
10.1523/JNEUROSCI.4987-09.2010
10.1038/ncb2000
10.1080/20013078.2019.1689784
10.1136/svn-2020-000419
10.1161/STROKEAHA.108.533166
10.1523/JNEUROSCI.2129-13.2013
10.1523/JNEUROSCI.4303-11.2012
10.1016/j.neuron.2016.11.030
10.1523/JNEUROSCI.18-19-07768.1998
10.1089/neu.2015.4101
10.1016/j.stem.2020.07.006
10.1152/physrev.00042.2016
10.1007/s13311-016-0477-8
10.7554/eLife.59733
10.1038/nn.4043
10.1038/nn.2963
10.1038/onc.2014.66
10.1172/JCI81134
10.1016/S0896-6273(02)00722-5
10.1038/s41467-017-01283-z
10.1038/nn.2535
10.1038/nature17623
10.1242/dev.129304
10.1002/ana.24653
10.1016/j.cell.2015.04.042
10.1016/j.celrep.2015.06.040
10.1006/dbio.2000.0106
10.1038/s41419-019-2100-5
10.1016/j.celrep.2021.109048
10.1016/j.cell.2021.09.005
10.1038/nature10202
10.3390/cells9071732
10.1038/s41598-018-20421-1
10.1126/science.1228773
10.1126/science.346.6206.237
10.1038/nm.2753
10.1161/STROKEAHA.120.031728
10.1523/JNEUROSCI.3975-14.2015
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OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763251/
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PublicationDate 2022-12-19
PublicationDateYYYYMMDD 2022-12-19
PublicationDate_xml – month: 12
  year: 2022
  text: 2022-12-19
  day: 19
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PublicationTitle Nature communications
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Nature Publishing Group
Nature Portfolio
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References Schaeffer, Iadecola (CR13) 2021; 24
Magnusson (CR8) 2014; 346
Zuchero, Barres (CR53) 2015; 142
Bouet (CR63) 2009; 4
Torper (CR51) 2015; 12
Khakh, Sofroniew (CR54) 2015; 18
Sharp, Liu, Bernabeu (CR1) 2002; 134
Sweeney, Zhao, Montagne, Nelson, Zlokovic (CR37) 2019; 99
Tyzack (CR39) 2017; 8
Grande (CR55) 2013; 4
Cekanaviciute, Buckwalter (CR43) 2016; 13
Qian (CR49) 2020; 582
Yue (CR14) 2019; 10
Lee (CR30) 2018; 12
Kisanuki (CR58) 2001; 230
Aga (CR31) 2014; 33
Zappulli, Friis, Fitzpatrick, Maguire, Breakefield (CR46) 2016; 126
Zhang, Buller, Chopp (CR48) 2019; 15
Shen (CR10) 2004; 304
Zhou (CR50) 2020; 181
Nato (CR36) 2015; 142
ShenSantopolo, Magnusson, Lindvall, Kokaia, Frisen (CR9) 2020; 9
Zhou (CR29) 2018; 8
Egawa (CR26) 2020; 40
Srinivas (CR60) 2001; 1
Li, Tang, Yang (CR47) 2021; 6
Wang (CR34) 2021; 184
Liang (CR4) 2019; 116
Webb (CR32) 2013; 4
Goldman, Chen (CR11) 2011; 14
Carmichael (CR3) 2016; 79
Zomer (CR22) 2015; 161
Williamson, Fuertes, Dunn, Drew, Jones (CR45) 2021; 35
Pang (CR27) 2011; 476
Xing, Lo (CR38) 2017; 152
Liu, Chopp (CR42) 2016; 144
Imayoshi, Sakamoto, Yamaguchi, Mori, Kageyama (CR17) 2010; 30
Ostrowski (CR21) 2010; 12
Choi (CR62) 2016; 22
Louissaint, Rao, Leventhal, Goldman (CR12) 2002; 34
Chen (CR23) 2013; 499
Llorens-Bobadilla (CR35) 2015; 17
Pnevmatikakis (CR24) 2019; 55
Shimada, LeComte, Granger, Quinlan, Spees (CR7) 2012; 32
Takano, Oberheim, Cotrina, Nedergaard (CR41) 2009; 40
Peinado (CR56) 2012; 18
Li (CR16) 2021; 41
Liu, Solway, Messing, Sharp (CR6) 1998; 18
Ortinski (CR33) 2010; 13
Hermann, Chopp (CR2) 2012; 11
Srinivasan (CR59) 2016; 92
Pan (CR15) 2016; 9
Magnusson (CR19) 2020; 9
Verkhratsky, Nedergaard (CR52) 2018; 98
Yekula (CR57) 2020; 9
Scemes, Giaume (CR25) 2006; 54
Zhang (CR20) 2020; 51
Guo (CR61) 2016; 33
Sun (CR5) 2013; 33
Liu (CR28) 2015; 35
Anderson (CR44) 2016; 532
Zamboni, Llorens-Bobadilla, Magnusson, Frisen (CR18) 2020; 27
Kyritsis (CR40) 2012; 338
JB Zuchero (35498_CR53) 2015; 142
A Yekula (35498_CR57) 2020; 9
M Ostrowski (35498_CR21) 2010; 12
O Torper (35498_CR51) 2015; 12
YK Choi (35498_CR62) 2016; 22
MR Williamson (35498_CR45) 2021; 35
JP Magnusson (35498_CR19) 2020; 9
A Louissaint Jr. (35498_CR12) 2002; 34
N Egawa (35498_CR26) 2020; 40
H Peinado (35498_CR56) 2012; 18
R Srinivasan (35498_CR59) 2016; 92
YY Kisanuki (35498_CR58) 2001; 230
Y Zhang (35498_CR20) 2020; 51
S Guo (35498_CR61) 2016; 33
C Sun (35498_CR5) 2013; 33
Y Li (35498_CR47) 2021; 6
A Verkhratsky (35498_CR52) 2018; 98
Y Liu (35498_CR28) 2015; 35
H Liang (35498_CR4) 2019; 116
C Li (35498_CR16) 2021; 41
DM Hermann (35498_CR2) 2012; 11
A Zomer (35498_CR22) 2015; 161
GE Tyzack (35498_CR39) 2017; 8
FR Sharp (35498_CR1) 2002; 134
Z Liu (35498_CR42) 2016; 144
S Srinivas (35498_CR60) 2001; 1
JP Magnusson (35498_CR8) 2014; 346
H Qian (35498_CR49) 2020; 582
Q Pan (35498_CR15) 2016; 9
G Nato (35498_CR36) 2015; 142
G ShenSantopolo (35498_CR9) 2020; 9
PI Ortinski (35498_CR33) 2010; 13
S Schaeffer (35498_CR13) 2021; 24
J Liu (35498_CR6) 1998; 18
M Zamboni (35498_CR18) 2020; 27
SA Goldman (35498_CR11) 2011; 14
E Scemes (35498_CR25) 2006; 54
MD Sweeney (35498_CR37) 2019; 99
C Xing (35498_CR38) 2017; 152
ST Carmichael (35498_CR3) 2016; 79
Q Shen (35498_CR10) 2004; 304
V Bouet (35498_CR63) 2009; 4
A Grande (35498_CR55) 2013; 4
TW Chen (35498_CR23) 2013; 499
ZG Zhang (35498_CR48) 2019; 15
H Zhou (35498_CR50) 2020; 181
KY Yue (35498_CR14) 2019; 10
E Llorens-Bobadilla (35498_CR35) 2015; 17
E Cekanaviciute (35498_CR43) 2016; 13
IS Shimada (35498_CR7) 2012; 32
MA Anderson (35498_CR44) 2016; 532
M Aga (35498_CR31) 2014; 33
J Zhou (35498_CR29) 2018; 8
AE Webb (35498_CR32) 2013; 4
N Kyritsis (35498_CR40) 2012; 338
LL Wang (35498_CR34) 2021; 184
BS Khakh (35498_CR54) 2015; 18
ZP Pang (35498_CR27) 2011; 476
EA Pnevmatikakis (35498_CR24) 2019; 55
I Imayoshi (35498_CR17) 2010; 30
YS Lee (35498_CR30) 2018; 12
T Takano (35498_CR41) 2009; 40
V Zappulli (35498_CR46) 2016; 126
References_xml – volume: 99
  start-page: 21
  year: 2019
  end-page: 78
  ident: CR37
  article-title: Blood-brain barrier: from physiology to disease and back
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00050.2017
  contributor:
    fullname: Zlokovic
– volume: 582
  start-page: 550
  year: 2020
  end-page: 556
  ident: CR49
  article-title: Reversing a model of Parkinson’s disease with in situ converted nigral neurons
  publication-title: Nature
  doi: 10.1038/s41586-020-2388-4
  contributor:
    fullname: Qian
– volume: 11
  start-page: 369
  year: 2012
  end-page: 380
  ident: CR2
  article-title: Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(12)70039-X
  contributor:
    fullname: Chopp
– volume: 304
  start-page: 1338
  year: 2004
  end-page: 1340
  ident: CR10
  article-title: Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells
  publication-title: Science
  doi: 10.1126/science.1095505
  contributor:
    fullname: Shen
– volume: 22
  start-page: 1335
  year: 2016
  end-page: 1341
  ident: CR62
  article-title: Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury
  publication-title: Nat. Med.
  doi: 10.1038/nm.4188
  contributor:
    fullname: Choi
– volume: 17
  start-page: 329
  year: 2015
  end-page: 340
  ident: CR35
  article-title: Single-cell transcriptomics reveals a population of dormant neural stem cells that become activated upon brain injury
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.07.002
  contributor:
    fullname: Llorens-Bobadilla
– volume: 181
  start-page: 590
  year: 2020
  end-page: 603 e516
  ident: CR50
  article-title: Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.024
  contributor:
    fullname: Zhou
– volume: 4
  start-page: 1560
  year: 2009
  end-page: 1564
  ident: CR63
  article-title: The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2009.125
  contributor:
    fullname: Bouet
– volume: 24
  start-page: 1198
  year: 2021
  end-page: 1209
  ident: CR13
  article-title: Revisiting the neurovascular unit
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-021-00904-7
  contributor:
    fullname: Iadecola
– volume: 55
  start-page: 15
  year: 2019
  end-page: 21
  ident: CR24
  article-title: Analysis pipelines for calcium imaging data
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2018.11.004
  contributor:
    fullname: Pnevmatikakis
– volume: 54
  start-page: 716
  year: 2006
  end-page: 725
  ident: CR25
  article-title: Astrocyte calcium waves: what they are and what they do
  publication-title: Glia
  doi: 10.1002/glia.20374
  contributor:
    fullname: Giaume
– volume: 144
  start-page: 103
  year: 2016
  end-page: 120
  ident: CR42
  article-title: Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2015.09.008
  contributor:
    fullname: Chopp
– volume: 40
  start-page: 1739
  year: 2020
  end-page: 1751
  ident: CR26
  article-title: From in vitro to in vivo reprogramming for neural transdifferentiation: an approach for CNS tissue remodeling using stem cell technology
  publication-title: J. Cereb. Blood Flow Metab
  doi: 10.1177/0271678X20910324
  contributor:
    fullname: Egawa
– volume: 12
  start-page: 2531
  year: 2018
  end-page: 2538
  ident: CR30
  article-title: Exosome-mediated ultra-effective direct conversion of human fibroblasts into neural progenitor-like cells
  publication-title: ACS Nano
  doi: 10.1021/acsnano.7b08297
  contributor:
    fullname: Lee
– volume: 499
  start-page: 295
  year: 2013
  end-page: 300
  ident: CR23
  article-title: Ultrasensitive fluorescent proteins for imaging neuronal activity
  publication-title: Nature
  doi: 10.1038/nature12354
  contributor:
    fullname: Chen
– volume: 4
  start-page: 477
  year: 2013
  end-page: 491
  ident: CR32
  article-title: FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.06.035
  contributor:
    fullname: Webb
– volume: 142
  start-page: 840
  year: 2015
  end-page: 845
  ident: CR36
  article-title: Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington’s disease
  publication-title: Development
  contributor:
    fullname: Nato
– volume: 116
  start-page: 13621
  year: 2019
  end-page: 13630
  ident: CR4
  article-title: Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1811825116
  contributor:
    fullname: Liang
– volume: 152
  start-page: 181
  year: 2017
  end-page: 199
  ident: CR38
  article-title: Help-me signaling: non-cell autonomous mechanisms of neuroprotection and neurorecovery
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2016.04.004
  contributor:
    fullname: Lo
– volume: 9
  year: 2016
  ident: CR15
  article-title: Microvascular endothelial cells-derived microvesicles imply in ischemic stroke by modulating astrocyte and blood brain barrier function and cerebral blood flow
  publication-title: Mol. Brain
  doi: 10.1186/s13041-016-0243-1
  contributor:
    fullname: Pan
– volume: 4
  year: 2013
  ident: CR55
  article-title: Environmental impact on direct neuronal reprogramming in vivo in the adult brain
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3373
  contributor:
    fullname: Grande
– volume: 134
  start-page: 23
  year: 2002
  end-page: 30
  ident: CR1
  article-title: Neurogenesis following brain ischemia
  publication-title: Brain Res. Dev. Brain Res.
  doi: 10.1016/S0165-3806(01)00286-3
  contributor:
    fullname: Bernabeu
– volume: 1
  start-page: 4
  year: 2001
  ident: CR60
  article-title: Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-1-4
  contributor:
    fullname: Srinivas
– volume: 41
  start-page: 2090
  year: 2021
  end-page: 2104
  ident: CR16
  article-title: Cerebral endothelial cell-derived small extracellular vesicles enhance neurovascular function and neurological recovery in rat acute ischemic stroke models of mechanical thrombectomy and embolic stroke treatment with tPA
  publication-title: J. Cereb. Blood Flow. Metab.
  doi: 10.1177/0271678X21992980
  contributor:
    fullname: Li
– volume: 15
  start-page: 193
  year: 2019
  end-page: 203
  ident: CR48
  article-title: Exosomes - beyond stem cells for restorative therapy in stroke and neurological injury
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/s41582-018-0126-4
  contributor:
    fullname: Chopp
– volume: 30
  start-page: 3489
  year: 2010
  end-page: 3498
  ident: CR17
  article-title: Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4987-09.2010
  contributor:
    fullname: Kageyama
– volume: 12
  start-page: 19
  year: 2010
  end-page: 30
  ident: CR21
  article-title: Rab27a and Rab27b control different steps of the exosome secretion pathway
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2000
  contributor:
    fullname: Ostrowski
– volume: 9
  start-page: 1689784
  year: 2020
  ident: CR57
  article-title: Large and small extracellular vesicles released by glioma cells in vitro and in vivo
  publication-title: J. Extracell. Vesicles
  doi: 10.1080/20013078.2019.1689784
  contributor:
    fullname: Yekula
– volume: 6
  start-page: 483
  year: 2021
  end-page: 495
  ident: CR47
  article-title: Therapeutic application of exosomes in ischaemic stroke
  publication-title: Stroke Vasc. Neurol
  doi: 10.1136/svn-2020-000419
  contributor:
    fullname: Yang
– volume: 40
  start-page: S8
  year: 2009
  end-page: S12
  ident: CR41
  article-title: Astrocytes and ischemic injury
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.533166
  contributor:
    fullname: Nedergaard
– volume: 33
  start-page: 17314
  year: 2013
  end-page: 17325
  ident: CR5
  article-title: Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2129-13.2013
  contributor:
    fullname: Sun
– volume: 32
  start-page: 7926
  year: 2012
  end-page: 7940
  ident: CR7
  article-title: Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4303-11.2012
  contributor:
    fullname: Spees
– volume: 92
  start-page: 1181
  year: 2016
  end-page: 1195
  ident: CR59
  article-title: New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in situ and in vivo
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.11.030
  contributor:
    fullname: Srinivasan
– volume: 18
  start-page: 7768
  year: 1998
  end-page: 7778
  ident: CR6
  article-title: Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-19-07768.1998
  contributor:
    fullname: Sharp
– volume: 33
  start-page: 1303
  year: 2016
  end-page: 1316
  ident: CR61
  article-title: Effects of controlled cortical impact on the mouse brain vasculome
  publication-title: J. Neurotrauma
  doi: 10.1089/neu.2015.4101
  contributor:
    fullname: Guo
– volume: 27
  start-page: 605
  year: 2020
  end-page: 617 e605
  ident: CR18
  article-title: A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.07.006
  contributor:
    fullname: Frisen
– volume: 98
  start-page: 239
  year: 2018
  end-page: 389
  ident: CR52
  article-title: Physiology of astroglia
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00042.2016
  contributor:
    fullname: Nedergaard
– volume: 13
  start-page: 685
  year: 2016
  end-page: 701
  ident: CR43
  article-title: Astrocytes: integrative regulators of neuroinflammation in stroke and other neurological diseases
  publication-title: Neurotherapeutics
  doi: 10.1007/s13311-016-0477-8
  contributor:
    fullname: Buckwalter
– volume: 9
  start-page: e59733
  year: 2020
  ident: CR19
  article-title: Activation of a neural stem cell transcriptional program in parenchymal astrocytes
  publication-title: Elife
  doi: 10.7554/eLife.59733
  contributor:
    fullname: Magnusson
– volume: 18
  start-page: 942
  year: 2015
  end-page: 952
  ident: CR54
  article-title: Diversity of astrocyte functions and phenotypes in neural circuits
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4043
  contributor:
    fullname: Sofroniew
– volume: 14
  start-page: 1382
  year: 2011
  end-page: 1389
  ident: CR11
  article-title: Perivascular instruction of cell genesis and fate in the adult brain
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2963
  contributor:
    fullname: Chen
– volume: 33
  start-page: 4613
  year: 2014
  end-page: 4622
  ident: CR31
  article-title: Exosomal HIF1alpha supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes
  publication-title: Oncogene
  doi: 10.1038/onc.2014.66
  contributor:
    fullname: Aga
– volume: 126
  start-page: 1198
  year: 2016
  end-page: 1207
  ident: CR46
  article-title: Extracellular vesicles and intercellular communication within the nervous system
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI81134
  contributor:
    fullname: Breakefield
– volume: 34
  start-page: 945
  year: 2002
  end-page: 960
  ident: CR12
  article-title: Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)00722-5
  contributor:
    fullname: Goldman
– volume: 8
  year: 2017
  ident: CR39
  article-title: A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01283-z
  contributor:
    fullname: Tyzack
– volume: 13
  start-page: 584
  year: 2010
  end-page: 591
  ident: CR33
  article-title: Selective induction of astrocytic gliosis generates deficits in neuronal inhibition
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2535
  contributor:
    fullname: Ortinski
– volume: 532
  start-page: 195
  year: 2016
  end-page: 200
  ident: CR44
  article-title: Astrocyte scar formation aids central nervous system axon regeneration
  publication-title: Nature
  doi: 10.1038/nature17623
  contributor:
    fullname: Anderson
– volume: 142
  start-page: 3805
  year: 2015
  end-page: 3809
  ident: CR53
  article-title: Glia in mammalian development and disease
  publication-title: Development
  doi: 10.1242/dev.129304
  contributor:
    fullname: Barres
– volume: 79
  start-page: 895
  year: 2016
  end-page: 906
  ident: CR3
  article-title: Emergent properties of neural repair: elemental biology to therapeutic concepts
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.24653
  contributor:
    fullname: Carmichael
– volume: 161
  start-page: 1046
  year: 2015
  end-page: 1057
  ident: CR22
  article-title: In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior
  publication-title: Cell
  doi: 10.1016/j.cell.2015.04.042
  contributor:
    fullname: Zomer
– volume: 12
  start-page: 474
  year: 2015
  end-page: 481
  ident: CR51
  article-title: In vivo reprogramming of striatal NG2 glia into functional neurons that integrate into local host circuitry
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.06.040
  contributor:
    fullname: Torper
– volume: 230
  start-page: 230
  year: 2001
  end-page: 242
  ident: CR58
  article-title: Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.2000.0106
  contributor:
    fullname: Kisanuki
– volume: 10
  year: 2019
  ident: CR14
  article-title: Neurons can upregulate Cav-1 to increase intake of endothelial cells-derived extracellular vesicles that attenuate apoptosis via miR-1290
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-019-2100-5
  contributor:
    fullname: Yue
– volume: 35
  start-page: 109048
  year: 2021
  ident: CR45
  article-title: Reactive astrocytes facilitate vascular repair and remodeling after stroke
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109048
  contributor:
    fullname: Jones
– volume: 184
  start-page: 5465
  year: 2021
  end-page: 5481 e5416
  ident: CR34
  article-title: Revisiting astrocyte to neuron conversion with lineage tracing in vivo
  publication-title: Cell
  doi: 10.1016/j.cell.2021.09.005
  contributor:
    fullname: Wang
– volume: 476
  start-page: 220
  year: 2011
  end-page: 223
  ident: CR27
  article-title: Induction of human neuronal cells by defined transcription factors
  publication-title: Nature
  doi: 10.1038/nature10202
  contributor:
    fullname: Pang
– volume: 9
  start-page: 1732
  year: 2020
  ident: CR9
  article-title: Blocking notch-signaling increases neurogenesis in the striatum after stroke
  publication-title: Cells
  doi: 10.3390/cells9071732
  contributor:
    fullname: Frisen
– volume: 8
  year: 2018
  ident: CR29
  article-title: Retinal progenitor cells release extracellular vesicles containing developmental transcription factors, microRNA and membrane proteins
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20421-1
  contributor:
    fullname: Zhou
– volume: 338
  start-page: 1353
  year: 2012
  end-page: 1356
  ident: CR40
  article-title: Acute inflammation initiates the regenerative response in the adult zebrafish brain
  publication-title: Science
  doi: 10.1126/science.1228773
  contributor:
    fullname: Kyritsis
– volume: 346
  start-page: 237
  year: 2014
  end-page: 241
  ident: CR8
  article-title: A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
  publication-title: Science
  doi: 10.1126/science.346.6206.237
  contributor:
    fullname: Magnusson
– volume: 18
  start-page: 883
  year: 2012
  end-page: 891
  ident: CR56
  article-title: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
  publication-title: Nat. Med.
  doi: 10.1038/nm.2753
  contributor:
    fullname: Peinado
– volume: 51
  start-page: 3701
  year: 2020
  end-page: 3712
  ident: CR20
  article-title: Ischemic cerebral endothelial cell-derived exosomes promote axonal growth
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.120.031728
  contributor:
    fullname: Zhang
– volume: 35
  start-page: 9336
  year: 2015
  end-page: 9355
  ident: CR28
  article-title: Ascl1 converts dorsal midbrain astrocytes into functional neurons in vivo
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3975-14.2015
  contributor:
    fullname: Liu
– volume: 9
  start-page: 1732
  year: 2020
  ident: 35498_CR9
  publication-title: Cells
  doi: 10.3390/cells9071732
  contributor:
    fullname: G ShenSantopolo
– volume: 126
  start-page: 1198
  year: 2016
  ident: 35498_CR46
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI81134
  contributor:
    fullname: V Zappulli
– volume: 54
  start-page: 716
  year: 2006
  ident: 35498_CR25
  publication-title: Glia
  doi: 10.1002/glia.20374
  contributor:
    fullname: E Scemes
– volume: 142
  start-page: 840
  year: 2015
  ident: 35498_CR36
  publication-title: Development
  contributor:
    fullname: G Nato
– volume: 35
  start-page: 109048
  year: 2021
  ident: 35498_CR45
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.109048
  contributor:
    fullname: MR Williamson
– volume: 144
  start-page: 103
  year: 2016
  ident: 35498_CR42
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2015.09.008
  contributor:
    fullname: Z Liu
– volume: 11
  start-page: 369
  year: 2012
  ident: 35498_CR2
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(12)70039-X
  contributor:
    fullname: DM Hermann
– volume: 476
  start-page: 220
  year: 2011
  ident: 35498_CR27
  publication-title: Nature
  doi: 10.1038/nature10202
  contributor:
    fullname: ZP Pang
– volume: 8
  year: 2018
  ident: 35498_CR29
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20421-1
  contributor:
    fullname: J Zhou
– volume: 134
  start-page: 23
  year: 2002
  ident: 35498_CR1
  publication-title: Brain Res. Dev. Brain Res.
  doi: 10.1016/S0165-3806(01)00286-3
  contributor:
    fullname: FR Sharp
– volume: 304
  start-page: 1338
  year: 2004
  ident: 35498_CR10
  publication-title: Science
  doi: 10.1126/science.1095505
  contributor:
    fullname: Q Shen
– volume: 181
  start-page: 590
  year: 2020
  ident: 35498_CR50
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.024
  contributor:
    fullname: H Zhou
– volume: 230
  start-page: 230
  year: 2001
  ident: 35498_CR58
  publication-title: Dev. Biol.
  doi: 10.1006/dbio.2000.0106
  contributor:
    fullname: YY Kisanuki
– volume: 30
  start-page: 3489
  year: 2010
  ident: 35498_CR17
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4987-09.2010
  contributor:
    fullname: I Imayoshi
– volume: 99
  start-page: 21
  year: 2019
  ident: 35498_CR37
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00050.2017
  contributor:
    fullname: MD Sweeney
– volume: 142
  start-page: 3805
  year: 2015
  ident: 35498_CR53
  publication-title: Development
  doi: 10.1242/dev.129304
  contributor:
    fullname: JB Zuchero
– volume: 27
  start-page: 605
  year: 2020
  ident: 35498_CR18
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.07.006
  contributor:
    fullname: M Zamboni
– volume: 32
  start-page: 7926
  year: 2012
  ident: 35498_CR7
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4303-11.2012
  contributor:
    fullname: IS Shimada
– volume: 184
  start-page: 5465
  year: 2021
  ident: 35498_CR34
  publication-title: Cell
  doi: 10.1016/j.cell.2021.09.005
  contributor:
    fullname: LL Wang
– volume: 55
  start-page: 15
  year: 2019
  ident: 35498_CR24
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2018.11.004
  contributor:
    fullname: EA Pnevmatikakis
– volume: 116
  start-page: 13621
  year: 2019
  ident: 35498_CR4
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1811825116
  contributor:
    fullname: H Liang
– volume: 33
  start-page: 17314
  year: 2013
  ident: 35498_CR5
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2129-13.2013
  contributor:
    fullname: C Sun
– volume: 14
  start-page: 1382
  year: 2011
  ident: 35498_CR11
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2963
  contributor:
    fullname: SA Goldman
– volume: 22
  start-page: 1335
  year: 2016
  ident: 35498_CR62
  publication-title: Nat. Med.
  doi: 10.1038/nm.4188
  contributor:
    fullname: YK Choi
– volume: 92
  start-page: 1181
  year: 2016
  ident: 35498_CR59
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.11.030
  contributor:
    fullname: R Srinivasan
– volume: 40
  start-page: S8
  year: 2009
  ident: 35498_CR41
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.533166
  contributor:
    fullname: T Takano
– volume: 12
  start-page: 19
  year: 2010
  ident: 35498_CR21
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2000
  contributor:
    fullname: M Ostrowski
– volume: 1
  start-page: 4
  year: 2001
  ident: 35498_CR60
  publication-title: BMC Dev. Biol.
  doi: 10.1186/1471-213X-1-4
  contributor:
    fullname: S Srinivas
– volume: 34
  start-page: 945
  year: 2002
  ident: 35498_CR12
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)00722-5
  contributor:
    fullname: A Louissaint Jr.
– volume: 15
  start-page: 193
  year: 2019
  ident: 35498_CR48
  publication-title: Nat. Rev. Neurol.
  doi: 10.1038/s41582-018-0126-4
  contributor:
    fullname: ZG Zhang
– volume: 346
  start-page: 237
  year: 2014
  ident: 35498_CR8
  publication-title: Science
  doi: 10.1126/science.346.6206.237
  contributor:
    fullname: JP Magnusson
– volume: 499
  start-page: 295
  year: 2013
  ident: 35498_CR23
  publication-title: Nature
  doi: 10.1038/nature12354
  contributor:
    fullname: TW Chen
– volume: 10
  year: 2019
  ident: 35498_CR14
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-019-2100-5
  contributor:
    fullname: KY Yue
– volume: 582
  start-page: 550
  year: 2020
  ident: 35498_CR49
  publication-title: Nature
  doi: 10.1038/s41586-020-2388-4
  contributor:
    fullname: H Qian
– volume: 8
  year: 2017
  ident: 35498_CR39
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01283-z
  contributor:
    fullname: GE Tyzack
– volume: 18
  start-page: 883
  year: 2012
  ident: 35498_CR56
  publication-title: Nat. Med.
  doi: 10.1038/nm.2753
  contributor:
    fullname: H Peinado
– volume: 33
  start-page: 1303
  year: 2016
  ident: 35498_CR61
  publication-title: J. Neurotrauma
  doi: 10.1089/neu.2015.4101
  contributor:
    fullname: S Guo
– volume: 79
  start-page: 895
  year: 2016
  ident: 35498_CR3
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.24653
  contributor:
    fullname: ST Carmichael
– volume: 18
  start-page: 7768
  year: 1998
  ident: 35498_CR6
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.18-19-07768.1998
  contributor:
    fullname: J Liu
– volume: 18
  start-page: 942
  year: 2015
  ident: 35498_CR54
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4043
  contributor:
    fullname: BS Khakh
– volume: 41
  start-page: 2090
  year: 2021
  ident: 35498_CR16
  publication-title: J. Cereb. Blood Flow. Metab.
  doi: 10.1177/0271678X21992980
  contributor:
    fullname: C Li
– volume: 9
  start-page: e59733
  year: 2020
  ident: 35498_CR19
  publication-title: Elife
  doi: 10.7554/eLife.59733
  contributor:
    fullname: JP Magnusson
– volume: 9
  start-page: 1689784
  year: 2020
  ident: 35498_CR57
  publication-title: J. Extracell. Vesicles
  doi: 10.1080/20013078.2019.1689784
  contributor:
    fullname: A Yekula
– volume: 33
  start-page: 4613
  year: 2014
  ident: 35498_CR31
  publication-title: Oncogene
  doi: 10.1038/onc.2014.66
  contributor:
    fullname: M Aga
– volume: 24
  start-page: 1198
  year: 2021
  ident: 35498_CR13
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-021-00904-7
  contributor:
    fullname: S Schaeffer
– volume: 13
  start-page: 685
  year: 2016
  ident: 35498_CR43
  publication-title: Neurotherapeutics
  doi: 10.1007/s13311-016-0477-8
  contributor:
    fullname: E Cekanaviciute
– volume: 4
  start-page: 477
  year: 2013
  ident: 35498_CR32
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.06.035
  contributor:
    fullname: AE Webb
– volume: 9
  year: 2016
  ident: 35498_CR15
  publication-title: Mol. Brain
  doi: 10.1186/s13041-016-0243-1
  contributor:
    fullname: Q Pan
– volume: 152
  start-page: 181
  year: 2017
  ident: 35498_CR38
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2016.04.004
  contributor:
    fullname: C Xing
– volume: 4
  year: 2013
  ident: 35498_CR55
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms3373
  contributor:
    fullname: A Grande
– volume: 51
  start-page: 3701
  year: 2020
  ident: 35498_CR20
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.120.031728
  contributor:
    fullname: Y Zhang
– volume: 40
  start-page: 1739
  year: 2020
  ident: 35498_CR26
  publication-title: J. Cereb. Blood Flow Metab
  doi: 10.1177/0271678X20910324
  contributor:
    fullname: N Egawa
– volume: 532
  start-page: 195
  year: 2016
  ident: 35498_CR44
  publication-title: Nature
  doi: 10.1038/nature17623
  contributor:
    fullname: MA Anderson
– volume: 161
  start-page: 1046
  year: 2015
  ident: 35498_CR22
  publication-title: Cell
  doi: 10.1016/j.cell.2015.04.042
  contributor:
    fullname: A Zomer
– volume: 338
  start-page: 1353
  year: 2012
  ident: 35498_CR40
  publication-title: Science
  doi: 10.1126/science.1228773
  contributor:
    fullname: N Kyritsis
– volume: 6
  start-page: 483
  year: 2021
  ident: 35498_CR47
  publication-title: Stroke Vasc. Neurol
  doi: 10.1136/svn-2020-000419
  contributor:
    fullname: Y Li
– volume: 12
  start-page: 474
  year: 2015
  ident: 35498_CR51
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.06.040
  contributor:
    fullname: O Torper
– volume: 4
  start-page: 1560
  year: 2009
  ident: 35498_CR63
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2009.125
  contributor:
    fullname: V Bouet
– volume: 13
  start-page: 584
  year: 2010
  ident: 35498_CR33
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2535
  contributor:
    fullname: PI Ortinski
– volume: 17
  start-page: 329
  year: 2015
  ident: 35498_CR35
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.07.002
  contributor:
    fullname: E Llorens-Bobadilla
– volume: 12
  start-page: 2531
  year: 2018
  ident: 35498_CR30
  publication-title: ACS Nano
  doi: 10.1021/acsnano.7b08297
  contributor:
    fullname: YS Lee
– volume: 98
  start-page: 239
  year: 2018
  ident: 35498_CR52
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00042.2016
  contributor:
    fullname: A Verkhratsky
– volume: 35
  start-page: 9336
  year: 2015
  ident: 35498_CR28
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3975-14.2015
  contributor:
    fullname: Y Liu
SSID ssj0000391844
Score 2.5239418
Snippet The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for...
Abstract The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In...
Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial...
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pubmedcentral
proquest
crossref
pubmed
springer
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Open Access Repository
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Index Database
Publisher
StartPage 7812
SubjectTerms 14/28
631/378/2596/1308
631/378/2607
692/699/375/534
Animal models
Animals
ASCL1 protein
Astrocytes
Brain
Brain damage
Cell differentiation
Cell signaling
Cell Transdifferentiation
Cells, Cultured
Conversion
Deprivation
Differentiation
Endothelial Cells
Endothelium
Glucose
Humanities and Social Sciences
Ischemia
Male
Mice
multidisciplinary
Neural plasticity
Neural Stem Cells
Neurogenesis
Neuronal-glial interactions
Oxygen
Progenitor cells
Science
Science (multidisciplinary)
Stroke
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Title Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke
URI https://link.springer.com/article/10.1038/s41467-022-35498-6
https://www.ncbi.nlm.nih.gov/pubmed/36535938
https://www.proquest.com/docview/2755685793
https://search.proquest.com/docview/2756121893
https://pubmed.ncbi.nlm.nih.gov/PMC9763251
https://doaj.org/article/f63343dfedd9439ab7c83ba7559d3566
Volume 13
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