Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 274; no. 5; pp. R1482 - E1491
• Main Authors: Havel, P.J, Uriu-Hare, J.Y, Liu, T, Stanhope, K.L, Stern, J.S, Keen, C.L, Ahren, B
• Format: Journal Article
• Language: English
• Published: United States 01.05.1998
• Subjects: Animals; Blood Glucose - analysis; Body Weight; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - physiopathology; Eating; experimental design; Hypoglycemic Agents - pharmacology; Insulin - blood; Insulin - pharmacology; Leptin; Male; Proteins - metabolism; Rats; Rats, Sprague-Dawley; Streptozocin

Department of Nutrition, University of California, Davis, California 95616; and Department of Medicine, Lund University, S-20502 Malmö, Sweden Evidence for regulation of circulating leptin by insulin is conflicting. Diabetes was induced in rats with streptozotocin (STZ; 40 mg · kg 1 · day 1  × 2 day...