5-Azacytidine increases tanshinone production in Salvia miltiorrhiza hairy roots through epigenetic modulation

• Published in: Scientific reports Vol. 12; no. 1; pp. 9349 - 13
• Main Authors: Yang, Bo-Cheng, Lee, Meng-Shiou, Lin, Ming-Kuem, Chang, Wen-Te
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.06.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/449/2667; 631/61/447; Azacytidine; Binding sites; Biosynthesis; Demethylation; Deoxyribonucleic acid; DNA; DNA methylation; Epigenetics; Gene expression; Hairy root; Humanities and Social Sciences; Medicinal plants; Metabolites; multidisciplinary; Regulatory sequences; Roots; Salvia miltiorrhiza; Science; Science (multidisciplinary); Secondary metabolites; Tanshinones; Transcription factors

Recent studies have indicated strong connections between epigenetic modulation and secondary metabolites in plants. It is vital to understand the roles of epigenetics in the production of secondary metabolites. In this study, the inhibitor of DNA methylation 5-azacytidine (5-Az) was used on the hair...