Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans

• Published in: Nature communications Vol. 13; no. 1; pp. 768 - 14
• Main Authors: Wan, Qin-Li, Meng, Xiao, Wang, Chongyang, Dai, Wenyu, Luo, Zhenhuan, Yin, Zhinan, Ju, Zhenyu, Fu, Xiaodie, Yang, Jing, Ye, Qunshan, Zhang, Zhan-Hui, Zhou, Qinghua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.02.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 49/15; 49/91; 631/208/1515; 631/208/176; Accumulation; Animals; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - metabolism; Chromatin; Diet; Diet, High-Fat; Epigenesis, Genetic; Epigenetics; Epigenomics; Forkhead protein; Genes; Heredity; High fat diet; Histones; Histones - metabolism; Humanities and Social Sciences; Humans; Inheritance Patterns; Lipid Metabolism; Lipids; Metabolism; multidisciplinary; Nematodes; Nuclear receptors; Obesity; Offspring; Progeny; Protein Processing, Post-Translational; Receptors, Cytoplasmic and Nuclear - metabolism; Risk analysis; Risk factors; Science; Science (multidisciplinary); Sterol regulatory element-binding protein; Transcription factors

As a major risk factor to human health, obesity presents a massive burden to people and society. Interestingly, the obese status of parents can cause progeny’s lipid accumulation through epigenetic inheritance in multiple species. To date, many questions remain as to how lipid accumulation leads to...