Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice

• Published in: Scientific reports Vol. 10; no. 1; pp. 8183 - 10
• Main Authors: Dodiya, Hemraj B., Frith, Mary, Sidebottom, Ashley, Cao, Yajun, Koval, Jason, Chang, Eugene, Sisodia, Sangram S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.05.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/1426; 692/4020/2741/2135; 692/699/375/365/1283; Alzheimer Disease - complications; Amyloid; Amyloidosis; Amyloidosis - complications; Amyloidosis - microbiology; Animals; Anti-Bacterial Agents - pharmacology; Antibiotics; Antimicrobial agents; Brain; Cecum; Cecum - drug effects; Cecum - microbiology; Colistin; Consortia; Drinking water; Gastrointestinal Microbiome - drug effects; Gentamicin; Humanities and Social Sciences; Intestinal microflora; Kanamycin; Liquid chromatography; Male; Mass spectrometry; Mass spectroscopy; Metronidazole; Mice; Mice, Transgenic; Microbiomes; Microbiota; multidisciplinary; Rodents; Science; Science (multidisciplinary); Synergistic effect; Transgenic animals; Transgenic mice; Vancomycin

In preceding efforts, we demonstrated that antibiotic (ABX) cocktail-mediated perturbations of the gut microbiome in two independent transgenic lines, termed APP SWE / PS1 ΔE9 and APPPS1-21, leads to a reduction in Aβ deposition in male mice. To determine whether these observed reductions of cerebra...