Innate immunity: the first line of defense against SARS-CoV-2

• Published in: Nature immunology Vol. 23; no. 2; pp. 165 - 176
• Main Authors: Diamond, Michael S., Kanneganti, Thirumala-Devi
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2022; Nature Publishing Group
• Subjects: 631/250/2504; 631/250/262; 631/326/596/4130; Animals; Biomedical and Life Sciences; Biomedicine; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - metabolism; COVID-19 - virology; Cytokine storm; Cytokines; Cytokines - immunology; Cytokines - metabolism; Humans; Immune clearance; Immune Evasion; Immune system; Immunity, Innate; Immunology; Infectious Diseases; Inflammasomes - immunology; Inflammasomes - metabolism; Inflammation; Innate immunity; Morbidity; NLR Proteins - immunology; NLR Proteins - metabolism; Pandemics; Pattern recognition; Pattern recognition receptors; Receptors, Pattern Recognition - immunology; Receptors, Pattern Recognition - metabolism; Respiratory distress syndrome; Review Article; SARS-CoV-2 - immunology; SARS-CoV-2 - pathogenicity; Severe acute respiratory syndrome coronavirus 2; Signal Transduction; Toll-Like Receptors - immunology; Toll-Like Receptors - metabolism; Virus Internalization

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity and mortality. While most infections are mild, some patients experience severe and potentially fatal systemic inflammation, tissue damage,...