IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans

• Published in: Diabetologia Vol. 65; no. 8; pp. 1398 - 1411
• Main Authors: Pearson, James A., Ding, Heyuan, Hu, Changyun, Peng, Jian, Galuppo, Brittany, Wong, F. Susan, Caprio, Sonia, Santoro, Nicola, Wen, Li
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2022; Springer Nature B.V
• Subjects: Activation-induced cytidine deaminase; Adolescent; Animal models; Animals; Bacteria; Bacteria - genetics; Beta cells; Body weight gain; Child; Cytidine deaminase; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diet, High-Fat; Digestive system; Feces; Germfree; Glucose; Glucose tolerance; High fat diet; Human Physiology; Humans; Hypotheses; Immunoglobulin M; Immunological tolerance; Internal Medicine; Intestinal microflora; Intolerance; Medicine; Medicine & Public Health; Metabolic Diseases; Mice; Mice, Inbred C57BL; Microbiota; Obesity; Obesity - microbiology; RNA, Ribosomal, 16S - genetics; Rodents; rRNA 16S; Weight Gain; Type 2 diabetes; B cell; Obesity; Gut bacteria; IgM

Aims/hypothesis IgM is the primary antibody produced by B cells and we hypothesise that IgM antibodies to gut microbiota may play a role in immunometabolism in obesity and type 2 diabetes. To test our hypothesis, we used B6 mice deficient in activation-induced cytidine deaminase ( Aid −/− [also know...