Establishment of a repeated social defeat stress model in female mice

• Published in: Scientific reports Vol. 7; no. 1; pp. 12838 - 12
• Main Authors: Takahashi, Aki, Chung, Jia-Ru, Zhang, Song, Zhang, Hongxing, Grossman, Yael, Aleyasin, Hossein, Flanigan, Meghan E., Pfau, Madeline L., Menard, Caroline, Dumitriu, Dani, Hodes, Georgia E., McEwen, Bruce S., Nestler, Eric J., Han, Ming-Hu, Russo, Scott J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.10.2017; Nature Publishing Group
• Subjects: 631/378/1831; 631/378/3919; 64/60; 96/21; Aggression; Animals; Anxiety; Avoidance behavior; Avoidance Learning; Behavior; Behavior, Animal; Body weight; Disease Models, Animal; Female; Females; Humanities and Social Sciences; Hypothalamus (ventromedial); Interleukin 6; Male; Mental depression; Mice, Inbred C57BL; multidisciplinary; Neurobiology; Rodents; Science; Science (multidisciplinary); Sensation; Sex differences; Social Behavior; Social interactions; Stress, Psychological - pathology

Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed...