Establishment of a repeated social defeat stress model in female mice
Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed...
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| Published in | Scientific reports Vol. 7; no. 1; pp. 12838 - 12 |
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| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
09.10.2017
Nature Publishing Group |
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| Online Access | Get full text |
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| Abstract | Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). We demonstrate that females susceptible to RSDS display social avoidance, anxiety-like behavior, reduction of body weight, and elevated levels of circulating interleukin 6. In contrast, a subset of mice we term resilient only display anxiety-like behaviors after RSDS. This model allows for investigation of sex differences in the neurobiological mechanisms of defeat‒induced depression‒like behaviors. A robust female social defeat model is a critical first step in the identification and development of novel therapeutic compounds to treat depression and anxiety disorders in women. |
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| AbstractList | Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). We demonstrate that females susceptible to RSDS display social avoidance, anxiety-like behavior, reduction of body weight, and elevated levels of circulating interleukin 6. In contrast, a subset of mice we term resilient only display anxiety-like behaviors after RSDS. This model allows for investigation of sex differences in the neurobiological mechanisms of defeat‒induced depression‒like behaviors. A robust female social defeat model is a critical first step in the identification and development of novel therapeutic compounds to treat depression and anxiety disorders in women. Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). We demonstrate that females susceptible to RSDS display social avoidance, anxiety-like behavior, reduction of body weight, and elevated levels of circulating interleukin 6. In contrast, a subset of mice we term resilient only display anxiety-like behaviors after RSDS. This model allows for investigation of sex differences in the neurobiological mechanisms of defeat‒induced depression‒like behaviors. A robust female social defeat model is a critical first step in the identification and development of novel therapeutic compounds to treat depression and anxiety disorders in women.Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl). We demonstrate that females susceptible to RSDS display social avoidance, anxiety-like behavior, reduction of body weight, and elevated levels of circulating interleukin 6. In contrast, a subset of mice we term resilient only display anxiety-like behaviors after RSDS. This model allows for investigation of sex differences in the neurobiological mechanisms of defeat‒induced depression‒like behaviors. A robust female social defeat model is a critical first step in the identification and development of novel therapeutic compounds to treat depression and anxiety disorders in women. |
| ArticleNumber | 12838 |
| Author | Zhang, Hongxing Chung, Jia-Ru Han, Ming-Hu Menard, Caroline Aleyasin, Hossein Dumitriu, Dani Pfau, Madeline L. Russo, Scott J. McEwen, Bruce S. Zhang, Song Grossman, Yael Takahashi, Aki Hodes, Georgia E. Flanigan, Meghan E. Nestler, Eric J. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28993631$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nn.2647 10.1160/TH16-10-0817 10.1080/00221325.1961.10534371 10.1073/pnas.1415191111 10.1016/j.jpsychires.2011.03.006 10.1038/nprot.2011.361 10.1016/j.neuron.2016.01.040 10.1016/S0165-0327(99)00158-5 10.1016/j.ncl.2006.03.005 10.1016/S0140-6736(08)60522-X 10.1016/j.yhbeh.2006.06.022 10.1016/S0149-7634(98)00040-2 10.1016/j.yhbeh.2007.04.007 10.1016/j.socscimed.2011.05.006 10.1146/annurev.psych.48.1.191 10.1038/nature09736 10.1016/j.psychres.2010.07.042 10.1038/ncomms11671 10.1163/156853970X00402 10.1016/j.biopsych.2009.01.024 10.1016/j.bbr.2010.03.019 10.1126/science.1249240 10.1016/j.yhbeh.2003.05.001 10.1016/j.ynstr.2016.03.003 10.1016/0091-3057(91)90284-9 10.1038/nrn3381 10.1007/s00213-011-2364-7 10.1038/nn1659 10.1016/S0361-9230(99)00087-8 10.1523/JNEUROSCI.1392-15.2015 10.1126/science.1120972 10.1016/j.pharmthera.2008.07.006 10.1186/s13293-014-0017-3 10.1111/gbb.12310 10.1007/7854_2014_313 10.1038/nature13169 10.1016/j.biopsych.2009.12.003 10.1016/j.cell.2007.09.018 10.1016/S0031-9384(01)00449-8 10.1016/j.neuroscience.2013.01.073 10.1016/S0306-4530(98)00050-X 10.1016/j.neuroscience.2004.05.034 10.1073/pnas.0700293104 10.1001/archinte.164.9.1010 10.1111/ejn.12131 10.1017/S0033291701003907 10.1016/j.physbeh.2007.10.020 10.7554/eLife.18726 10.1016/j.bbr.2011.11.001 10.3389/fnins.2014.00231 10.1371/journal.pone.0017405 10.1016/S0031-9384(03)00209-9 |
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| References | HodesGEMénardCRussoSJIntegrating Interleukin-6 into depression diagnosis and treatmentNeurobiol. Stress20164152210.1016/j.ynstr.2016.03.003279811865146277 HuhmanKLConditioned defeat in male and female Syrian hamstersHorm. Behav.200344293910.1016/j.yhbeh.2003.05.00114609551 KrukMRCurrent topics in behavioral neurosciences20141714318810.1007/7854_2014_31324852798 DevriesKViolence against women is strongly associated with suicide attempts: evidence from the WHO multi-country study on women’s health and domestic violence against womenSoc. Sci. Med.201173798610.1016/j.socscimed.2011.05.00621676510 SeneyMLSibilleESex differences in mood disorders: perspectives from humans and rodent modelsBiol. Sex Differ.2014510.1186/s13293-014-0017-3255207744268901 KesslerRCThe effects of stressful life events on depressionAnnu. Rev. Psychol.1997481912141:STN:280:DyaK2s7pvVGitA%3D%3D10.1146/annurev.psych.48.1.1919046559 TrainorBCSex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus)PLoS One201162011PLoSO...617405T1:CAS:528:DC%2BC3MXjtVymtb4%3D10.1371/journal.pone.0017405213647683045459 RussoSJNestlerEJThe brain reward circuitry in mood disordersNat. Rev. Neurosci.2013146096251:CAS:528:DC%2BC3sXht1KgtrfP10.1038/nrn338123942470 KoolhaasJMDe BoerSFDe RutterAJMeerloPSgoifoASocial stress in rats and miceActa Physiol. Scand. Suppl.199764069721:STN:280:DyaK1c%2FmsFWgsA%3D%3D9401610 LeeHScalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamusNature20145096276322014Natur.509..627L1:CAS:528:DC%2BC2cXoslCrt78%3D10.1038/nature13169247399754098836 SanoKTsudaMCMusatovSSakamotoTOgawaSDifferential effects of site-specific knockdown of estrogen receptor α in the medial amygdala, medial pre-optic area, and ventromedial nucleus of the hypothalamus on sexual and aggressive behavior of male miceEur. J. Neurosci.2013371308131910.1111/ejn.1213123347260 SiegelARoelingTAGreggTRKrukMRNeuropharmacology of brain-stimulation-evoked aggressionNeurosci. Biobehav. Rev.199923359891:CAS:528:DyaK1MXhtFylt7c%3D10.1016/S0149-7634(98)00040-29989425 KornsteinSGGender differences in chronic major and double depressionJ. Affect. Disord.2000601111:STN:280:DC%2BD3cvnt1yltg%3D%3D10.1016/S0165-0327(99)00158-510940442 BlanchardRJMcKittrickCRBlanchardDCAnimal models of social stress: effects on behavior and brain neurochemical systemsPhysiol. Behav.200173261711:CAS:528:DC%2BD3MXkvVelurs%3D10.1016/S0031-9384(01)00449-811438351 BourkeCHNeighGNExposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female ratsBehav. Brain Res.2012227270510.1016/j.bbr.2011.11.00122093902 TsankovaNMSustained hippocampal chromatin regulation in a mouse model of depression and antidepressant actionNat. Neurosci.200695195251:CAS:528:DC%2BD28XivFSitb8%3D10.1038/nn165916501568 MiczekKAYapJJCovingtonHESocial stress, therapeutics and drug abuse: preclinical models of escalated and depressed intakePharmacol. Ther.2008120102281:CAS:528:DC%2BD1cXht1Knsb3N10.1016/j.pharmthera.2008.07.006187899662713609 Senst, L., Baimoukhametova, D., Sterley, T.-L. & Bains, J. S. Sexually dimorphic neuronal responses to social isolation. Elife5 (2016). KahnMWThe effect of socially learned aggression or submission on the mating behavior of C57 miceJ. Genet. Psychol.19619821171:STN:280:DyaF3c%2FntVCrsw%3D%3D10.1080/00221325.1961.1053437113750750 RuisMAHousing familiar male wildtype rats together reduces the long-term adverse behavioural and physiological effects of social defeatPsychoneuroendocrinology1999242853001:STN:280:DyaK1M3gtF2lsA%3D%3D10.1016/S0306-4530(98)00050-X10101734 SolomonMBKaromMCHuhmanKLSex and estrous cycle differences in the display of conditioned defeat in Syrian hamstersHorm. Behav.2007522112191:CAS:528:DC%2BD2sXotlSltrg%3D10.1016/j.yhbeh.2007.04.00717555756 FriedmanAKKCNQ channel openers reverse depressive symptoms via an active resilience mechanismNat. Commun.201672016NatCo...711671F1:CAS:528:DC%2BC28Xos12lu7o%3D10.1038/ncomms11671272165734890180 KendlerKSGardnerCONealeMCPrescottCAGenetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?Psychol. Med.200131605161:STN:280:DC%2BD3M3lsVagtA%3D%3D11352363 PayneAPSwansonHHAgonistic behaviour between pairs of hamsters of the same and opposite sex in a neutral observation areaBehaviour19703626091:STN:280:DyaE3M%2FptVSmsA%3D%3D10.1163/156853970X004025531509 HodesGEIndividual differences in the peripheral immune system promote resilience versus susceptibility to social stressProc. Natl. Acad. Sci.201411116136161412014PNAS..11116136H1:CAS:528:DC%2BC2cXhslyksLzL10.1073/pnas.1415191111253318954234602 ChuangJ-CA β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic StressBiol. Psychiatry201067107510821:CAS:528:DC%2BC3cXlvVWltbo%3D10.1016/j.biopsych.2009.12.003200609582868111 McLeanCPAsnaaniALitzBTHofmannSGGender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illnessJ. Psychiatr. Res.2011451027103510.1016/j.jpsychires.2011.03.006214395763135672 Ver HoeveESKellyGLuzSGhanshaniSBhatnagarSShort-term and long-term effects of repeated social defeat during adolescence or adulthood in female ratsNeuroscience201324963731:CAS:528:DC%2BC3sXjvFCmtLw%3D10.1016/j.neuroscience.2013.01.073234028523743933 ArmbrusterBNLiXPauschMHHerlitzeSRothBLEvolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandProc. Natl. Acad. Sci.2007104516351682007PNAS..104.5163A10.1073/pnas.0700293104173603451829280 DavisESMarlerCAc-fos Changes following an aggressive encounter in female California mice: a synthesis of behavior, hormone changes and neural activityNeuroscience2004127611241:CAS:528:DC%2BD2cXmt1Oht7s%3D10.1016/j.neuroscience.2004.05.03415283961 BartolomucciAChronic psychosocial stress persistently alters autonomic function and physical activity in micePhysiol. Behav.20038057671:CAS:528:DC%2BD3sXotVyku7k%3D10.1016/S0031-9384(03)00209-914568308 HuhmanKLSocial conflict models: Can they inform us about human psychopathology?Horm. Behav.20065064064610.1016/j.yhbeh.2006.06.02216870189 NestlerEJHymanSEAnimal models of neuropsychiatric disordersNat. Neurosci.201013116111691:CAS:528:DC%2BC3cXht1Wjt7vJ10.1038/nn.2647208772803750731 NajtPFusar-PoliPBrambillaPCo-occurring mental and substance abuse disorders: A review on the potential predictors and clinical outcomesPsychiatry Res.201118615916410.1016/j.psychres.2010.07.04220728943 EllsbergMIntimate partner violence and women’s physical and mental health in the WHO multi-country study on women’s health and domestic violence: an observational studyLancet (London, England)200837111657210.1016/S0140-6736(08)60522-X BertonOEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stressScience200631186482006Sci...311..864B1:CAS:528:DC%2BD28XhtFyltr0%3D10.1126/science.112097216469931 KrishnanVMolecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward RegionsCell20071313914041:CAS:528:DC%2BD2sXht1KqsbfN10.1016/j.cell.2007.09.01817956738 GoldenSAPersistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 miceGenes Brain Behav.201616445510.1111/gbb.1231027457669 HallerJFuchsEHalászJMakaraGBDefeat is a major stressor in males while social instability is stressful mainly in females: towards the development of a social stress model in female ratsBrain Res. Bull.1999503391:STN:280:DyaK1MvjsFejsQ%3D%3D10.1016/S0361-9230(99)00087-810507469 KudryavtsevaNNBakshtanovskayaIVKoryakinaLASocial model of depression in mice of C57BL/6J strainPharmacol. Biochem. Behav.199138315201:STN:280:DyaK3M3nvFyjsw%3D%3D10.1016/0091-3057(91)90284-92057501 ChourbajiSThe suitability of 129SvEv mice for studying depressive-like behaviour: both males and females develop learned helplessnessBehav. Brain Res.20102111051010.1016/j.bbr.2010.03.01920230860 LaPlantQRole of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female miceBiol. Psychiatry200965874801:CAS:528:DC%2BD1MXltFWnsLo%3D10.1016/j.biopsych.2009.01.024192512492746634 RothBLDREADDs for NeuroscientistsNeuron2016896836941:CAS:528:DC%2BC28XivVGksrk%3D10.1016/j.neuron.2016.01.040268898094759656 FordDEErlingerTPDepression and C-Reactive Protein in US AdultsArch. Intern. Med.200416410.1001/archinte.164.9.101015136311 WHO, Department of Reproductive Health and Research, London School of Hygiene and Tropical Medicine & South African Medical Research Council. Global and regional estimates of violence against women. WHO (World Health Organization, 2013). HodesGESex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable StressJ. Neurosci.20153516362163761:CAS:528:DC%2BC28Xos1Ogsrk%3D10.1523/JNEUROSCI.1392-15.2015266748634679819 LinDFunctional identification of an aggression locus in the mouse hypothalamusNature20114702212262011Natur.470..221L1:CAS:528:DC%2BC3MXhslWrt74%3D10.1038/nature09736213079353075820 FriedmanAKEnhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic ResilienceScience20143443133192014Sci...344..313F1:CAS:528:DC%2BC2cXmtV2ksrk%3D10.1126/science.1249240247443794334447 AsabaAHattoriTMogiKKikusuiTSexual attractiveness of male chemicals and vocalizations in miceFront. Neurosci.2014810.3389/fnins.2014.00231251401254122165 DallaCSex differences in the effects of two stress paradigms on dopaminergic neurotransmissionPhysiol. Behav.2008935956051:CAS:528:DC%2BD1cXhslGntLo%3D10.1016/j.physbeh.2007.10.02018031771 GiannarelliCSusceptibility to chronic social stress increases plaque progression, vulnerability and platelet activationThromb. Haemost.201711781681810.1160/TH16-10-0817280783525490439 Shimamoto, A., Debold, J. F., Holly, E. N. & Miczek, K. A. Blunted accumbal dopamine resp MB Solomon (12811_CR47) 2007; 52 C Giannarelli (12811_CR25) 2017; 117 ML Seney (12811_CR9) 2014; 5 Q LaPlant (12811_CR41) 2009; 65 AP Payne (12811_CR44) 1970; 36 12811_CR39 GE Hodes (12811_CR22) 2014; 111 KL Huhman (12811_CR19) 2006; 50 J-C Chuang (12811_CR24) 2010; 67 12811_CR1 RJ Blanchard (12811_CR21) 2001; 73 GE Hodes (12811_CR38) 2016; 4 A Bartolomucci (12811_CR13) 2003; 80 EJ Nestler (12811_CR27) 2010; 13 AK Friedman (12811_CR29) 2016; 7 J Haller (12811_CR52) 1999; 50 RC Kessler (12811_CR4) 1997; 48 V Krishnan (12811_CR18) 2007; 131 MR Kruk (12811_CR32) 2014; 17 D Lin (12811_CR33) 2011; 470 BC Trainor (12811_CR48) 2011; 6 A Siegel (12811_CR31) 1999; 23 SG Kornstein (12811_CR7) 2000; 60 SA Golden (12811_CR12) 2011; 6 SA Golden (12811_CR36) 2016; 16 BN Armbruster (12811_CR53) 2007; 104 KS Kendler (12811_CR10) 2001; 31 ES Ver Hoeve (12811_CR51) 2013; 249 O Berton (12811_CR17) 2006; 311 SJ Russo (12811_CR28) 2013; 14 K Devries (12811_CR2) 2011; 73 GE Hodes (12811_CR11) 2015; 35 ES Davis (12811_CR45) 2004; 127 NN Kudryavtseva (12811_CR14) 1991; 38 AK Friedman (12811_CR30) 2014; 344 C Dalla (12811_CR42) 2008; 93 MW Kahn (12811_CR20) 1961; 98 BL Roth (12811_CR54) 2016; 89 R Avitsur (12811_CR23) 2006; 24 CH Bourke (12811_CR50) 2012; 227 NM Tsankova (12811_CR26) 2006; 9 H Lee (12811_CR34) 2014; 509 DE Ford (12811_CR5) 2004; 164 A Asaba (12811_CR37) 2014; 8 CP McLean (12811_CR6) 2011; 45 M Ellsberg (12811_CR3) 2008; 371 S Chourbaji (12811_CR43) 2010; 211 12811_CR49 KA Miczek (12811_CR15) 2008; 120 JM Koolhaas (12811_CR16) 1997; 640 KL Huhman (12811_CR46) 2003; 44 P Najt (12811_CR8) 2011; 186 K Sano (12811_CR35) 2013; 37 MA Ruis (12811_CR40) 1999; 24 |
| References_xml | – reference: NestlerEJHymanSEAnimal models of neuropsychiatric disordersNat. Neurosci.201013116111691:CAS:528:DC%2BC3cXht1Wjt7vJ10.1038/nn.2647208772803750731 – reference: GoldenSAPersistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 miceGenes Brain Behav.201616445510.1111/gbb.1231027457669 – reference: ArmbrusterBNLiXPauschMHHerlitzeSRothBLEvolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandProc. Natl. Acad. Sci.2007104516351682007PNAS..104.5163A10.1073/pnas.0700293104173603451829280 – reference: WHO, Department of Reproductive Health and Research, London School of Hygiene and Tropical Medicine & South African Medical Research Council. Global and regional estimates of violence against women. WHO (World Health Organization, 2013). – reference: KrukMRCurrent topics in behavioral neurosciences20141714318810.1007/7854_2014_31324852798 – reference: LeeHScalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamusNature20145096276322014Natur.509..627L1:CAS:528:DC%2BC2cXoslCrt78%3D10.1038/nature13169247399754098836 – reference: KrishnanVMolecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward RegionsCell20071313914041:CAS:528:DC%2BD2sXht1KqsbfN10.1016/j.cell.2007.09.01817956738 – reference: DallaCSex differences in the effects of two stress paradigms on dopaminergic neurotransmissionPhysiol. Behav.2008935956051:CAS:528:DC%2BD1cXhslGntLo%3D10.1016/j.physbeh.2007.10.02018031771 – reference: LaPlantQRole of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female miceBiol. Psychiatry200965874801:CAS:528:DC%2BD1MXltFWnsLo%3D10.1016/j.biopsych.2009.01.024192512492746634 – reference: BlanchardRJMcKittrickCRBlanchardDCAnimal models of social stress: effects on behavior and brain neurochemical systemsPhysiol. Behav.200173261711:CAS:528:DC%2BD3MXkvVelurs%3D10.1016/S0031-9384(01)00449-811438351 – reference: EllsbergMIntimate partner violence and women’s physical and mental health in the WHO multi-country study on women’s health and domestic violence: an observational studyLancet (London, England)200837111657210.1016/S0140-6736(08)60522-X – reference: KendlerKSGardnerCONealeMCPrescottCAGenetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?Psychol. Med.200131605161:STN:280:DC%2BD3M3lsVagtA%3D%3D11352363 – reference: MiczekKAYapJJCovingtonHESocial stress, therapeutics and drug abuse: preclinical models of escalated and depressed intakePharmacol. Ther.2008120102281:CAS:528:DC%2BD1cXht1Knsb3N10.1016/j.pharmthera.2008.07.006187899662713609 – reference: RothBLDREADDs for NeuroscientistsNeuron2016896836941:CAS:528:DC%2BC28XivVGksrk%3D10.1016/j.neuron.2016.01.040268898094759656 – reference: AvitsurRPadgettDASheridanJFSocial Interactions, Stress, and ImmunityNeurol. Clin.20062448349110.1016/j.ncl.2006.03.00516877119 – reference: KahnMWThe effect of socially learned aggression or submission on the mating behavior of C57 miceJ. Genet. Psychol.19619821171:STN:280:DyaF3c%2FntVCrsw%3D%3D10.1080/00221325.1961.1053437113750750 – reference: RussoSJNestlerEJThe brain reward circuitry in mood disordersNat. Rev. Neurosci.2013146096251:CAS:528:DC%2BC3sXht1KgtrfP10.1038/nrn338123942470 – reference: HodesGEMénardCRussoSJIntegrating Interleukin-6 into depression diagnosis and treatmentNeurobiol. Stress20164152210.1016/j.ynstr.2016.03.003279811865146277 – reference: SolomonMBKaromMCHuhmanKLSex and estrous cycle differences in the display of conditioned defeat in Syrian hamstersHorm. Behav.2007522112191:CAS:528:DC%2BD2sXotlSltrg%3D10.1016/j.yhbeh.2007.04.00717555756 – reference: DevriesKViolence against women is strongly associated with suicide attempts: evidence from the WHO multi-country study on women’s health and domestic violence against womenSoc. Sci. Med.201173798610.1016/j.socscimed.2011.05.00621676510 – reference: BourkeCHNeighGNExposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female ratsBehav. Brain Res.2012227270510.1016/j.bbr.2011.11.00122093902 – reference: GoldenSACovingtonHEBertonORussoSJA standardized protocol for repeated social defeat stress in miceNat. Protoc.201161183911:CAS:528:DC%2BC3MXpsFSjtr8%3D10.1038/nprot.2011.361217994873220278 – reference: BartolomucciAChronic psychosocial stress persistently alters autonomic function and physical activity in micePhysiol. Behav.20038057671:CAS:528:DC%2BD3sXotVyku7k%3D10.1016/S0031-9384(03)00209-914568308 – reference: PayneAPSwansonHHAgonistic behaviour between pairs of hamsters of the same and opposite sex in a neutral observation areaBehaviour19703626091:STN:280:DyaE3M%2FptVSmsA%3D%3D10.1163/156853970X004025531509 – reference: TsankovaNMSustained hippocampal chromatin regulation in a mouse model of depression and antidepressant actionNat. Neurosci.200695195251:CAS:528:DC%2BD28XivFSitb8%3D10.1038/nn165916501568 – reference: FordDEErlingerTPDepression and C-Reactive Protein in US AdultsArch. Intern. Med.200416410.1001/archinte.164.9.101015136311 – reference: LinDFunctional identification of an aggression locus in the mouse hypothalamusNature20114702212262011Natur.470..221L1:CAS:528:DC%2BC3MXhslWrt74%3D10.1038/nature09736213079353075820 – reference: AsabaAHattoriTMogiKKikusuiTSexual attractiveness of male chemicals and vocalizations in miceFront. Neurosci.2014810.3389/fnins.2014.00231251401254122165 – reference: KudryavtsevaNNBakshtanovskayaIVKoryakinaLASocial model of depression in mice of C57BL/6J strainPharmacol. Biochem. Behav.199138315201:STN:280:DyaK3M3nvFyjsw%3D%3D10.1016/0091-3057(91)90284-92057501 – reference: SanoKTsudaMCMusatovSSakamotoTOgawaSDifferential effects of site-specific knockdown of estrogen receptor α in the medial amygdala, medial pre-optic area, and ventromedial nucleus of the hypothalamus on sexual and aggressive behavior of male miceEur. J. Neurosci.2013371308131910.1111/ejn.1213123347260 – reference: SiegelARoelingTAGreggTRKrukMRNeuropharmacology of brain-stimulation-evoked aggressionNeurosci. Biobehav. Rev.199923359891:CAS:528:DyaK1MXhtFylt7c%3D10.1016/S0149-7634(98)00040-29989425 – reference: SeneyMLSibilleESex differences in mood disorders: perspectives from humans and rodent modelsBiol. Sex Differ.2014510.1186/s13293-014-0017-3255207744268901 – reference: ChourbajiSThe suitability of 129SvEv mice for studying depressive-like behaviour: both males and females develop learned helplessnessBehav. Brain Res.20102111051010.1016/j.bbr.2010.03.01920230860 – reference: HuhmanKLConditioned defeat in male and female Syrian hamstersHorm. Behav.200344293910.1016/j.yhbeh.2003.05.00114609551 – reference: Shimamoto, A., Debold, J. F., Holly, E. N. & Miczek, K. A. Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse. Psychopharmacology (Berl). (2011). – reference: HodesGESex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable StressJ. Neurosci.20153516362163761:CAS:528:DC%2BC28Xos1Ogsrk%3D10.1523/JNEUROSCI.1392-15.2015266748634679819 – reference: HodesGEIndividual differences in the peripheral immune system promote resilience versus susceptibility to social stressProc. Natl. Acad. Sci.201411116136161412014PNAS..11116136H1:CAS:528:DC%2BC2cXhslyksLzL10.1073/pnas.1415191111253318954234602 – reference: Senst, L., Baimoukhametova, D., Sterley, T.-L. & Bains, J. S. Sexually dimorphic neuronal responses to social isolation. Elife5 (2016). – reference: TrainorBCSex differences in social interaction behavior following social defeat stress in the monogamous California mouse (Peromyscus californicus)PLoS One201162011PLoSO...617405T1:CAS:528:DC%2BC3MXjtVymtb4%3D10.1371/journal.pone.0017405213647683045459 – reference: RuisMAHousing familiar male wildtype rats together reduces the long-term adverse behavioural and physiological effects of social defeatPsychoneuroendocrinology1999242853001:STN:280:DyaK1M3gtF2lsA%3D%3D10.1016/S0306-4530(98)00050-X10101734 – reference: BertonOEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stressScience200631186482006Sci...311..864B1:CAS:528:DC%2BD28XhtFyltr0%3D10.1126/science.112097216469931 – reference: GiannarelliCSusceptibility to chronic social stress increases plaque progression, vulnerability and platelet activationThromb. Haemost.201711781681810.1160/TH16-10-0817280783525490439 – reference: NajtPFusar-PoliPBrambillaPCo-occurring mental and substance abuse disorders: A review on the potential predictors and clinical outcomesPsychiatry Res.201118615916410.1016/j.psychres.2010.07.04220728943 – reference: KesslerRCThe effects of stressful life events on depressionAnnu. Rev. Psychol.1997481912141:STN:280:DyaK2s7pvVGitA%3D%3D10.1146/annurev.psych.48.1.1919046559 – reference: HallerJFuchsEHalászJMakaraGBDefeat is a major stressor in males while social instability is stressful mainly in females: towards the development of a social stress model in female ratsBrain Res. Bull.1999503391:STN:280:DyaK1MvjsFejsQ%3D%3D10.1016/S0361-9230(99)00087-810507469 – reference: McLeanCPAsnaaniALitzBTHofmannSGGender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illnessJ. Psychiatr. Res.2011451027103510.1016/j.jpsychires.2011.03.006214395763135672 – reference: Ver HoeveESKellyGLuzSGhanshaniSBhatnagarSShort-term and long-term effects of repeated social defeat during adolescence or adulthood in female ratsNeuroscience201324963731:CAS:528:DC%2BC3sXjvFCmtLw%3D10.1016/j.neuroscience.2013.01.073234028523743933 – reference: KornsteinSGGender differences in chronic major and double depressionJ. Affect. Disord.2000601111:STN:280:DC%2BD3cvnt1yltg%3D%3D10.1016/S0165-0327(99)00158-510940442 – reference: HuhmanKLSocial conflict models: Can they inform us about human psychopathology?Horm. Behav.20065064064610.1016/j.yhbeh.2006.06.02216870189 – reference: FriedmanAKKCNQ channel openers reverse depressive symptoms via an active resilience mechanismNat. Commun.201672016NatCo...711671F1:CAS:528:DC%2BC28Xos12lu7o%3D10.1038/ncomms11671272165734890180 – reference: KoolhaasJMDe BoerSFDe RutterAJMeerloPSgoifoASocial stress in rats and miceActa Physiol. Scand. Suppl.199764069721:STN:280:DyaK1c%2FmsFWgsA%3D%3D9401610 – reference: ChuangJ-CA β3-Adrenergic-Leptin-Melanocortin Circuit Regulates Behavioral and Metabolic Changes Induced by Chronic StressBiol. Psychiatry201067107510821:CAS:528:DC%2BC3cXlvVWltbo%3D10.1016/j.biopsych.2009.12.003200609582868111 – reference: DavisESMarlerCAc-fos Changes following an aggressive encounter in female California mice: a synthesis of behavior, hormone changes and neural activityNeuroscience2004127611241:CAS:528:DC%2BD2cXmt1Oht7s%3D10.1016/j.neuroscience.2004.05.03415283961 – reference: FriedmanAKEnhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic ResilienceScience20143443133192014Sci...344..313F1:CAS:528:DC%2BC2cXmtV2ksrk%3D10.1126/science.1249240247443794334447 – volume: 13 start-page: 1161 year: 2010 ident: 12811_CR27 publication-title: Nat. Neurosci. doi: 10.1038/nn.2647 – volume: 117 start-page: 816 year: 2017 ident: 12811_CR25 publication-title: Thromb. Haemost. doi: 10.1160/TH16-10-0817 – volume: 98 start-page: 211 year: 1961 ident: 12811_CR20 publication-title: J. Genet. Psychol. doi: 10.1080/00221325.1961.10534371 – volume: 111 start-page: 16136 year: 2014 ident: 12811_CR22 publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.1415191111 – volume: 45 start-page: 1027 year: 2011 ident: 12811_CR6 publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2011.03.006 – volume: 6 start-page: 1183 year: 2011 ident: 12811_CR12 publication-title: Nat. Protoc. doi: 10.1038/nprot.2011.361 – volume: 640 start-page: 69 year: 1997 ident: 12811_CR16 publication-title: Acta Physiol. Scand. Suppl. – volume: 89 start-page: 683 year: 2016 ident: 12811_CR54 publication-title: Neuron doi: 10.1016/j.neuron.2016.01.040 – volume: 60 start-page: 1 year: 2000 ident: 12811_CR7 publication-title: J. Affect. Disord. doi: 10.1016/S0165-0327(99)00158-5 – volume: 24 start-page: 483 year: 2006 ident: 12811_CR23 publication-title: Neurol. Clin. doi: 10.1016/j.ncl.2006.03.005 – volume: 371 start-page: 1165 year: 2008 ident: 12811_CR3 publication-title: Lancet (London, England) doi: 10.1016/S0140-6736(08)60522-X – volume: 50 start-page: 640 year: 2006 ident: 12811_CR19 publication-title: Horm. Behav. doi: 10.1016/j.yhbeh.2006.06.022 – volume: 23 start-page: 359 year: 1999 ident: 12811_CR31 publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/S0149-7634(98)00040-2 – volume: 52 start-page: 211 year: 2007 ident: 12811_CR47 publication-title: Horm. Behav. doi: 10.1016/j.yhbeh.2007.04.007 – volume: 73 start-page: 79 year: 2011 ident: 12811_CR2 publication-title: Soc. Sci. Med. doi: 10.1016/j.socscimed.2011.05.006 – volume: 48 start-page: 191 year: 1997 ident: 12811_CR4 publication-title: Annu. Rev. Psychol. doi: 10.1146/annurev.psych.48.1.191 – volume: 470 start-page: 221 year: 2011 ident: 12811_CR33 publication-title: Nature doi: 10.1038/nature09736 – volume: 186 start-page: 159 year: 2011 ident: 12811_CR8 publication-title: Psychiatry Res. doi: 10.1016/j.psychres.2010.07.042 – volume: 7 year: 2016 ident: 12811_CR29 publication-title: Nat. Commun. doi: 10.1038/ncomms11671 – volume: 36 start-page: 260 year: 1970 ident: 12811_CR44 publication-title: Behaviour doi: 10.1163/156853970X00402 – volume: 65 start-page: 874 year: 2009 ident: 12811_CR41 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2009.01.024 – volume: 211 start-page: 105 year: 2010 ident: 12811_CR43 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2010.03.019 – volume: 344 start-page: 313 year: 2014 ident: 12811_CR30 publication-title: Science doi: 10.1126/science.1249240 – volume: 44 start-page: 293 year: 2003 ident: 12811_CR46 publication-title: Horm. Behav. doi: 10.1016/j.yhbeh.2003.05.001 – volume: 4 start-page: 15 year: 2016 ident: 12811_CR38 publication-title: Neurobiol. Stress doi: 10.1016/j.ynstr.2016.03.003 – volume: 38 start-page: 315 year: 1991 ident: 12811_CR14 publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/0091-3057(91)90284-9 – volume: 14 start-page: 609 year: 2013 ident: 12811_CR28 publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3381 – ident: 12811_CR49 doi: 10.1007/s00213-011-2364-7 – volume: 9 start-page: 519 year: 2006 ident: 12811_CR26 publication-title: Nat. Neurosci. doi: 10.1038/nn1659 – volume: 50 start-page: 33 year: 1999 ident: 12811_CR52 publication-title: Brain Res. Bull. doi: 10.1016/S0361-9230(99)00087-8 – volume: 35 start-page: 16362 year: 2015 ident: 12811_CR11 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1392-15.2015 – volume: 311 start-page: 864 year: 2006 ident: 12811_CR17 publication-title: Science doi: 10.1126/science.1120972 – volume: 120 start-page: 102 year: 2008 ident: 12811_CR15 publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2008.07.006 – volume: 5 year: 2014 ident: 12811_CR9 publication-title: Biol. Sex Differ. doi: 10.1186/s13293-014-0017-3 – volume: 16 start-page: 44 year: 2016 ident: 12811_CR36 publication-title: Genes Brain Behav. doi: 10.1111/gbb.12310 – volume: 17 start-page: 143 year: 2014 ident: 12811_CR32 publication-title: Current topics in behavioral neurosciences doi: 10.1007/7854_2014_313 – volume: 509 start-page: 627 year: 2014 ident: 12811_CR34 publication-title: Nature doi: 10.1038/nature13169 – volume: 67 start-page: 1075 year: 2010 ident: 12811_CR24 publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2009.12.003 – volume: 131 start-page: 391 year: 2007 ident: 12811_CR18 publication-title: Cell doi: 10.1016/j.cell.2007.09.018 – volume: 73 start-page: 261 year: 2001 ident: 12811_CR21 publication-title: Physiol. Behav. doi: 10.1016/S0031-9384(01)00449-8 – volume: 249 start-page: 63 year: 2013 ident: 12811_CR51 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2013.01.073 – volume: 24 start-page: 285 year: 1999 ident: 12811_CR40 publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(98)00050-X – ident: 12811_CR1 – volume: 127 start-page: 611 year: 2004 ident: 12811_CR45 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2004.05.034 – volume: 104 start-page: 5163 year: 2007 ident: 12811_CR53 publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.0700293104 – volume: 164 year: 2004 ident: 12811_CR5 publication-title: Arch. Intern. Med. doi: 10.1001/archinte.164.9.1010 – volume: 37 start-page: 1308 year: 2013 ident: 12811_CR35 publication-title: Eur. J. Neurosci. doi: 10.1111/ejn.12131 – volume: 31 start-page: 605 year: 2001 ident: 12811_CR10 publication-title: Psychol. Med. doi: 10.1017/S0033291701003907 – volume: 93 start-page: 595 year: 2008 ident: 12811_CR42 publication-title: Physiol. Behav. doi: 10.1016/j.physbeh.2007.10.020 – ident: 12811_CR39 doi: 10.7554/eLife.18726 – volume: 227 start-page: 270 year: 2012 ident: 12811_CR50 publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2011.11.001 – volume: 8 year: 2014 ident: 12811_CR37 publication-title: Front. Neurosci. doi: 10.3389/fnins.2014.00231 – volume: 6 year: 2011 ident: 12811_CR48 publication-title: PLoS One doi: 10.1371/journal.pone.0017405 – volume: 80 start-page: 57 year: 2003 ident: 12811_CR13 publication-title: Physiol. Behav. doi: 10.1016/S0031-9384(03)00209-9 |
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| Title | Establishment of a repeated social defeat stress model in female mice |
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