Increased blood neutrophil extracellular traps (NETs) associated with early life stress: translational findings in recent-onset schizophrenia and rodent model

• Published in: Translational psychiatry Vol. 12; no. 1; pp. 526 - 11
• Main Authors: Corsi-Zuelli, Fabiana, Schneider, Ayda Henriques, Santos-Silva, Thamyris, Loureiro, Camila Marcelino, Shuhama, Rosana, Menezes, Paulo Rossi, Guimarães, Francisco Silveira, Gomes, Felipe Villela, Cunha, Fernando Queiroz, Louzada-Junior, Paulo, Del-Ben, Cristina Marta
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.12.2022; Nature Publishing Group
• Subjects: 13/1; 13/106; 13/21; 13/51; 14/63; 631/378; 692/53; 692/53/2421; 692/699/476/1799; 82/80; Animals; Behavioral Sciences; Biological Psychology; Child abuse & neglect; Child development; Extracellular Traps; Interleukin-6; Medicine; Medicine & Public Health; Neurosciences; Neutrophils; Pharmacotherapy; Psychiatry; Rats; Schizophrenia; Stress, Psychological

Higher levels of interleukin (IL)-6 and elevated neutrophil counts are consistently reported in the blood of patients with schizophrenia. Stressors during childhood and/or adolescence are major socioenvironmental risk factors for schizophrenia and may contribute to immune dysregulation. Previous stu...