Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ

• Published in: Nature communications Vol. 13; no. 1; pp. 2665 - 18
• Main Authors: Liu, Yi, Deguchi, Yasunori, Wei, Daoyan, Liu, Fuyao, Moussalli, Micheline J., Deguchi, Eriko, Li, Donghui, Wang, Huamin, Valentin, Lovie Ann, Colby, Jennifer K., Wang, Jing, Zheng, Xiaofeng, Ying, Haoqiang, Gagea, Mihai, Ji, Baoan, Shi, Jiaqi, Yao, James C., Zuo, Xiangsheng, Shureiqi, Imad
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/106; 13/44; 14/1; 14/105; 14/63; 42/89; 49; 49/91; 631/67/1504/1713; 631/67/2327; 631/67/327; 631/67/69; 631/67/70; 64/60; Adenocarcinoma; Aging; Animals; Cancer; Carcinogenesis; Carcinogenesis - genetics; Carcinogenesis - pathology; Carcinogens; Carcinoma in Situ - pathology; Carcinoma, Pancreatic Ductal - pathology; CC chemokine receptors; CCR2 protein; Epithelial cells; Epithelium; High fat diet; Humanities and Social Sciences; Humans; K-Ras protein; Ligands; Lipids; Macrophages; Mice; Monocyte chemoattractant protein 1; multidisciplinary; Mutants; Mutation; Pancreas; Pancreas - pathology; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; PPAR delta - genetics; Proto-Oncogene Proteins p21(ras) - genetics; Receptors; Science; Science (multidisciplinary); Suppressor cells; Tumor microenvironment; Tumor Microenvironment - genetics; Tumorigenesis; Tumors

Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to...