Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ

Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 13; no. 1; pp. 2665 - 18
Main Authors Liu, Yi, Deguchi, Yasunori, Wei, Daoyan, Liu, Fuyao, Moussalli, Micheline J., Deguchi, Eriko, Li, Donghui, Wang, Huamin, Valentin, Lovie Ann, Colby, Jennifer K., Wang, Jing, Zheng, Xiaofeng, Ying, Haoqiang, Gagea, Mihai, Ji, Baoan, Shi, Jiaqi, Yao, James C., Zuo, Xiangsheng, Shureiqi, Imad
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.05.2022
Nature Publishing Group
Nature Portfolio
Subjects
13
13/106
13/44
14/1
14/105
14/63
42/89
49
49/91
631/67/1504/1713
631/67/2327
631/67/327
631/67/69
631/67/70
64/60
Adenocarcinoma
Aging
Animals
Cancer
Carcinogenesis
Carcinogenesis - genetics
Carcinogenesis - pathology
Carcinogens
Carcinoma in Situ - pathology
Carcinoma, Pancreatic Ductal - pathology
CC chemokine receptors
CCR2 protein
Epithelial cells
Epithelium
High fat diet
Humanities and Social Sciences
Humans
K-Ras protein
Ligands
Lipids
Macrophages
Mice
Monocyte chemoattractant protein 1
multidisciplinary
Mutants
Mutation
Pancreas
Pancreas - pathology
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - pathology
PPAR delta - genetics
Proto-Oncogene Proteins p21(ras) - genetics
Receptors
Science
Science (multidisciplinary)
Suppressor cells
Tumor microenvironment
Tumor Microenvironment - genetics
Tumorigenesis
Tumors
Online AccessGet full text

Cover

Abstract Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRAS G12D ( KRAS mu ) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRAS mu pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs. Pancreatic intraepithelial neoplasia (PanIN) can develop into pancreatic ductal adenocarcinoma (PDAC), however, the factors which determine how this occurs are unknown. Here, the authors illustrate the role of PPARδ in the upregulation of CCL2, resulting in an immunosuppressive microenvironment, and driving the progression of PanIN to PDAC.
AbstractList Pancreatic intraepithelial neoplasia (PanIN) can develop into pancreatic ductal adenocarcinoma (PDAC), however, the factors which determine how this occurs are unknown. Here, the authors illustrate the role of PPARδ in the upregulation of CCL2, resulting in an immunosuppressive microenvironment, and driving the progression of PanIN to PDAC.
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRAS (KRAS ) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRAS pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs.
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRAS G12D ( KRAS mu ) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRAS mu pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs. Pancreatic intraepithelial neoplasia (PanIN) can develop into pancreatic ductal adenocarcinoma (PDAC), however, the factors which determine how this occurs are unknown. Here, the authors illustrate the role of PPARδ in the upregulation of CCL2, resulting in an immunosuppressive microenvironment, and driving the progression of PanIN to PDAC.
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRAS G12D ( KRAS mu ) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRAS mu pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs.
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRASG12D (KRASmu) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRASmu pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs.Pancreatic intraepithelial neoplasia (PanIN) can develop into pancreatic ductal adenocarcinoma (PDAC), however, the factors which determine how this occurs are unknown. Here, the authors illustrate the role of PPARδ in the upregulation of CCL2, resulting in an immunosuppressive microenvironment, and driving the progression of PanIN to PDAC.
Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRASG12D (KRASmu) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRASmu pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs.Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with aging. Although most PanIN lesions (PanINs) harbor oncogenic KRAS mutations that initiate pancreatic tumorigenesis; PanINs rarely progress to PDAC. Critical factors that promote this progression, especially targetable ones, remain poorly defined. We show that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, is upregulated in PanINs in humans and mice. Furthermore, PPARδ ligand activation by a high-fat diet or GW501516 (a highly selective, synthetic PPARδ ligand) in mutant KRASG12D (KRASmu) pancreatic epithelial cells strongly accelerates PanIN progression to PDAC. This PPARδ activation induces KRASmu pancreatic epithelial cells to secrete CCL2, which recruits immunosuppressive macrophages and myeloid-derived suppressor cells into pancreas via the CCL2/CCR2 axis to orchestrate an immunosuppressive tumor microenvironment and subsequently drive PanIN progression to PDAC. Our data identify PPARδ signaling as a potential molecular target to prevent PDAC development in subjects harboring PanINs.
ArticleNumber 2665
Author Wang, Huamin
Deguchi, Yasunori
Valentin, Lovie Ann
Zheng, Xiaofeng
Yao, James C.
Ying, Haoqiang
Ji, Baoan
Liu, Fuyao
Wang, Jing
Shureiqi, Imad
Moussalli, Micheline J.
Deguchi, Eriko
Zuo, Xiangsheng
Wei, Daoyan
Gagea, Mihai
Liu, Yi
Colby, Jennifer K.
Li, Donghui
Shi, Jiaqi
Author_xml – sequence: 1
  givenname: Yi
  orcidid: 0000-0001-9748-0650
  surname: Liu
  fullname: Liu, Yi
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 2
  givenname: Yasunori
  surname: Deguchi
  fullname: Deguchi, Yasunori
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 3
  givenname: Daoyan
  surname: Wei
  fullname: Wei, Daoyan
  organization: Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center
– sequence: 4
  givenname: Fuyao
  surname: Liu
  fullname: Liu, Fuyao
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 5
  givenname: Micheline J.
  surname: Moussalli
  fullname: Moussalli, Micheline J.
  organization: Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Rogel Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan
– sequence: 6
  givenname: Eriko
  surname: Deguchi
  fullname: Deguchi, Eriko
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 7
  givenname: Donghui
  surname: Li
  fullname: Li, Donghui
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 8
  givenname: Huamin
  orcidid: 0000-0002-2038-5863
  surname: Wang
  fullname: Wang, Huamin
  organization: Department of Pathology, The University of Texas MD Anderson Cancer Center
– sequence: 9
  givenname: Lovie Ann
  surname: Valentin
  fullname: Valentin, Lovie Ann
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 10
  givenname: Jennifer K.
  surname: Colby
  fullname: Colby, Jennifer K.
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 11
  givenname: Jing
  orcidid: 0000-0002-5398-0802
  surname: Wang
  fullname: Wang, Jing
  organization: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
– sequence: 12
  givenname: Xiaofeng
  surname: Zheng
  fullname: Zheng, Xiaofeng
  organization: Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
– sequence: 13
  givenname: Haoqiang
  orcidid: 0000-0003-0616-2310
  surname: Ying
  fullname: Ying, Haoqiang
  organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 14
  givenname: Mihai
  orcidid: 0000-0002-2399-1375
  surname: Gagea
  fullname: Gagea, Mihai
  organization: Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center
– sequence: 15
  givenname: Baoan
  surname: Ji
  fullname: Ji, Baoan
  organization: Department of Cancer Biology, Mayo Clinic
– sequence: 16
  givenname: Jiaqi
  orcidid: 0000-0003-4893-1587
  surname: Shi
  fullname: Shi, Jiaqi
  organization: Department of Pathology, University of Michigan
– sequence: 17
  givenname: James C.
  surname: Yao
  fullname: Yao, James C.
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 18
  givenname: Xiangsheng
  orcidid: 0000-0002-8593-1132
  surname: Zuo
  fullname: Zuo, Xiangsheng
  email: xzuo@mdanderson.org
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center
– sequence: 19
  givenname: Imad
  orcidid: 0000-0003-2019-938X
  surname: Shureiqi
  fullname: Shureiqi, Imad
  email: ishureiq@med.umich.edu
  organization: Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Rogel Cancer Center and Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35562376$$D View this record in MEDLINE/PubMed
BookMark eNp9ks1u1DAQxyNUREvpC3BAkbhwCfgrcXxBWlV8VFSiWuBsTezJ4lViL3ayUt-L5-CZ8O620PZQX2x5_v-fZzzzvDjywWNRvKTkLSW8fZcEFY2sCGMVJ1yxSj4pThgRtKKS8aM75-PiLKU1yYsr2grxrDjmdd0wLpuTYl7CxtkSjMEBI0wu-DL05Zfl4ls1zhP4qdyANxFzyJQGonE-rNBjcqncOigjjsHi4Pxq55vmMcTSjePssRydiQH91sXgR8yk7rq8ulos__x-UTztYUh4drOfFj8-fvh-_rm6_Prp4nxxWZlakKkCjoRayTtmwXIp-77vABUYKogyfc1UZywyopgVsgXomagRcomkRoPc8tPi4sC1AdZ6E90I8VoHcHp_EeJKQ8yFDailwVbITijshWCyb4nEznLR9BYa1TaZ9f7A2szdiNbkgiIM96D3I9791Kuw1YqSRtId4M0NIIZfM6ZJjy7lbx_AY5iTZk0j8quEqCx9_UC6DnP0-at2Kt6yliiZVa_uZvQvldvuZkF7EOQ-pBSx18ZN-x7nBN2gKdG7WdKHWdJ5lvR-lvSOzR5Yb-mPmvjBlLLYrzD-T_sR118iR96v
CitedBy_id crossref_primary_10_3724_abbs_2023045
crossref_primary_10_1002_1873_3468_14959
crossref_primary_10_3390_cancers16030559
crossref_primary_10_3390_ijms25073961
crossref_primary_10_1021_acs_jproteome_4c01002
crossref_primary_10_1177_17562848231224943
crossref_primary_10_1158_2159_8290_CD_22_0661
crossref_primary_10_1016_j_biopha_2023_115179
crossref_primary_10_1093_carcin_bgae064
crossref_primary_10_1007_s12033_024_01131_8
crossref_primary_10_1016_j_aquatox_2024_107021
crossref_primary_10_3389_fphar_2025_1513948
crossref_primary_10_3390_ijms241914546
crossref_primary_10_3390_cells11142155
crossref_primary_10_1007_s10120_023_01418_w
crossref_primary_10_1038_s43018_023_00703_y
crossref_primary_10_1038_s41392_024_01848_7
crossref_primary_10_1093_toxsci_kfae129
crossref_primary_10_1016_j_bbcan_2024_189183
crossref_primary_10_3390_cells11152432
crossref_primary_10_1016_j_semcancer_2023_11_002
crossref_primary_10_3390_cancers15061635
crossref_primary_10_1186_s12964_023_01063_x
crossref_primary_10_3390_ijms24043114
crossref_primary_10_1158_2159_8290_CD_22_0876
crossref_primary_10_3390_ijms25052953
crossref_primary_10_1016_j_ejphar_2023_176304
crossref_primary_10_1186_s12944_025_02468_y
crossref_primary_10_1186_s12967_023_04486_9
crossref_primary_10_1016_j_clnu_2023_12_005
crossref_primary_10_3390_cancers15020521
crossref_primary_10_3390_ijms24119313
crossref_primary_10_1016_j_actbio_2023_05_047
crossref_primary_10_3389_fonc_2022_947238
crossref_primary_10_1016_j_bbcan_2023_188984
crossref_primary_10_1016_j_aquatox_2023_106514
crossref_primary_10_1038_s41419_024_06915_z
crossref_primary_10_1186_s12943_024_02218_1
Cites_doi 10.1053/j.gastro.2012.09.059
10.1172/JCI59743
10.1016/S0140-6736(16)00141-0
10.1053/j.gastro.2019.03.018
10.1053/j.gastro.2013.01.071
10.1097/01.MP.0000087422.24733.62
10.1053/j.gastro.2011.12.042
10.1016/S0092-8674(00)81664-5
10.1016/j.atherosclerosis.2011.10.029
10.1038/onc.2012.619
10.1152/ajpgi.00123.2018
10.1097/MPA.0b013e318220e742
10.1016/j.ccr.2012.04.025
10.1371/journal.pone.0184455
10.1111/cas.13766
10.1155/2013/121956
10.1073/pnas.1324233111
10.1097/00000478-200105000-00003
10.1093/aje/kwx036
10.1016/j.celrep.2016.04.084
10.1158/1078-0432.CCR-13-0525
10.1165/rcmb.2007-0426OC
10.1073/pnas.012610299
10.1038/s41575-021-00470-0
10.1158/0008-5472.CAN-12-2731
10.1053/j.gastro.2009.05.052
10.1053/j.gastro.2019.07.030
10.1096/fj.14-264515
10.1158/1940-6207.CAPR-13-0065
10.1158/0008-5472.CAN-18-1790
10.1158/0008-5472.CAN-09-4672
10.1136/gutjnl-2013-306271
10.1093/jnci/djp168
10.1038/nm993
10.2337/db07-1318
10.1053/gast.1996.v110.pm8536861
10.1158/0008-5472.CAN-13-1558-T
10.1016/j.molimm.2019.11.014
10.1172/jci.insight.91419
10.1186/s12967-019-1817-3
10.1111/j.1365-2613.2009.00667.x
10.1073/pnas.0802864106
10.1158/2159-8290.CD-19-0597
10.1053/j.gastro.2013.08.018
10.1073/pnas.0705505104
10.1016/j.ccell.2016.02.005
10.1073/pnas.97.24.13275
10.1016/S1535-6108(03)00309-X
10.1016/j.cell.2017.07.007
10.1093/jnci/dji292
10.1158/0008-5472.CAN-11-0908
10.1038/onc.2012.549
10.1073/pnas.1910856117
10.1101/gad.275776.115
10.1016/j.cell.2012.01.058
10.1021/ml200199c
10.1002/path.1515
10.1084/jem.20201803
10.1097/MPA.0000000000000786
10.3390/ijms19113339
ContentType Journal Article
Copyright The Author(s) 2022
2022. The Author(s).
The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2022
– notice: 2022. The Author(s).
– notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-022-30392-7
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection (Proquest)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection (Proquest)
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
PML(ProQuest Medical Library)
Biological Science Database (Proquest)
Advanced Technologies & Aerospace Collection
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE


CrossRef
Publicly Available Content Database
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 18
ExternalDocumentID oai_doaj_org_article_7ce847b49ef4427f807ebd346fda6986
PMC9106716
35562376
10_1038_s41467_022_30392_7
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
– fundername: Division of Cancer Prevention, National Cancer Institute (NCI Division of Cancer Prevention)
  grantid: R01CA266223
  funderid: https://doi.org/10.13039/100007316
– fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
  grantid: R01CA142969; R01CA195686; R01-CA206539; R01CA236905; R01CA236905; R03CA235106; K08CA234222
  funderid: https://doi.org/10.13039/100000054
– fundername: NCI NIH HHS
  grantid: R01 CA195686
– fundername: NCI NIH HHS
  grantid: R01 CA266223
– fundername: NCI NIH HHS
  grantid: P30 CA016672
– fundername: NCI NIH HHS
  grantid: R03 CA235106
– fundername: NCI NIH HHS
  grantid: R01 CA142969
– fundername: NCI NIH HHS
  grantid: R01 CA206539
– fundername: NCI NIH HHS
  grantid: K08 CA234222
– fundername: NCI NIH HHS
  grantid: R01 CA236905
– fundername: ;
– fundername: ;
  grantid: R01CA266223
– fundername: ;
  grantid: R01CA142969; R01CA195686; R01-CA206539; R01CA236905; R01CA236905; R03CA235106; K08CA234222
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c540t-a3e01d73b2dad377fffbae9ac1409cf529bcde2092d478aaf245ea84405ece3d3
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 01:27:39 EDT 2025
Thu Aug 21 18:25:25 EDT 2025
Mon Jul 21 10:41:51 EDT 2025
Wed Aug 13 08:05:09 EDT 2025
Mon Jul 21 06:04:42 EDT 2025
Thu Apr 24 23:02:02 EDT 2025
Tue Jul 01 00:58:12 EDT 2025
Fri Feb 21 02:38:46 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2022. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-a3e01d73b2dad377fffbae9ac1409cf529bcde2092d478aaf245ea84405ece3d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-5398-0802
0000-0001-9748-0650
0000-0003-4893-1587
0000-0003-0616-2310
0000-0002-2399-1375
0000-0003-2019-938X
0000-0002-2038-5863
0000-0002-8593-1132
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41467-022-30392-7
PMID 35562376
PQID 2663828097
PQPubID 546298
PageCount 18
ParticipantIDs doaj_primary_oai_doaj_org_article_7ce847b49ef4427f807ebd346fda6986
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9106716
proquest_miscellaneous_2664807009
proquest_journals_2663828097
pubmed_primary_35562376
crossref_citationtrail_10_1038_s41467_022_30392_7
crossref_primary_10_1038_s41467_022_30392_7
springer_journals_10_1038_s41467_022_30392_7
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-05-13
PublicationDateYYYYMMDD 2022-05-13
PublicationDate_xml – month: 05
  year: 2022
  text: 2022-05-13
  day: 13
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Zuo (CR41) 2019; 157
Risérus (CR27) 2008; 57
Georgoudaki (CR39) 2016; 15
Sanford (CR43) 2013; 19
Ying (CR30) 2012; 149
Xue (CR47) 2011; 2
CR38
Luo (CR49) 2009; 90
Hori (CR11) 2011; 40
Nöthlings (CR8) 2005; 97
Bayne (CR55) 2012; 21
Charafe-Jauffret (CR60) 2004; 202
Choi (CR26) 2012; 220
Wei (CR59) 2016; 29
Wang (CR52) 2014; 111
Abdollahi (CR22) 2007; 104
Hingorani (CR28) 2003; 4
Philip (CR12) 2013; 145
Chang (CR14) 2017; 12
Gordon-Dseagu (CR10) 2017; 186
Hruban (CR2) 2001; 25
Grizzi (CR29) 2019; 17
CR3
Zuo (CR24) 2017; 2
Adhikary (CR31) 2013; 32
Corcoran (CR35) 2011; 71
Ji (CR36) 2009; 137
Shao, Sheng, DuBois (CR48) 2002; 62
Tada (CR50) 1996; 110
Stromnes (CR54) 2014; 63
Kanda (CR6) 2012; 142
Pedchenko, Gonzalez, Wang, DuBois, Massion (CR23) 2008; 39
Thiébaut (CR9) 2009; 101
He, Chan, Vogelstein, Kinzler (CR20) 1999; 99
Zhang (CR34) 2013; 73
CR19
Daniluk (CR58) 2012; 122
Mitchem (CR46) 2013; 73
Mao (CR51) 2015; 29
Hou (CR45) 2020; 10
Coleman, Thompson, Smith, Prokopczyk, Vanden Heuvel (CR25) 2013; 2013
Nadella (CR17) 2018; 315
Kamisawa, Wood, Itoi, Takaori (CR1) 2016; 388
Barak (CR32) 2002; 99
Gupta (CR33) 2004; 10
Huang (CR57) 2013; 144
Singhi, Wood (CR5) 2021; 18
Khasawneh (CR13) 2009; 106
Yan (CR62) 2016; 2016
Huang (CR37) 2014; 33
Liu (CR61) 2019; 79
di Magliano, Logsdon (CR7) 2013; 144
Dawson (CR15) 2013; 6
Ying (CR53) 2016; 30
Li, Garstka, Li (CR56) 2020; 117
Luo (CR16) 2019; 157
Movahedi (CR40) 2010; 70
Andea, Sarkar, Adsay (CR4) 2003; 16
Gupta (CR21) 2000; 97
Takahashi (CR18) 2018; 109
Flores-Toro (CR44) 2020; 117
Badea, Herlea, Dima, Dumitrascu, Popescu (CR63) 2008; 55
Roe (CR42) 2017; 170
M Takahashi (30392_CR18) 2018; 109
J Khasawneh (30392_CR13) 2009; 106
Y Luo (30392_CR16) 2019; 157
U Risérus (30392_CR27) 2008; 57
30392_CR38
E Charafe-Jauffret (30392_CR60) 2004; 202
DE Sanford (30392_CR43) 2013; 19
H Huang (30392_CR37) 2014; 33
JA Flores-Toro (30392_CR44) 2020; 117
AD Singhi (30392_CR5) 2021; 18
S Nadella (30392_CR17) 2018; 315
F Mao (30392_CR51) 2015; 29
VLZ Gordon-Dseagu (30392_CR10) 2017; 186
CB Xue (30392_CR47) 2011; 2
RH Hruban (30392_CR2) 2001; 25
30392_CR3
AM Georgoudaki (30392_CR39) 2016; 15
A Andea (30392_CR4) 2003; 16
MP di Magliano (30392_CR7) 2013; 144
RA Gupta (30392_CR21) 2000; 97
T Kamisawa (30392_CR1) 2016; 388
H Ying (30392_CR53) 2016; 30
YJ Choi (30392_CR26) 2012; 220
X Zuo (30392_CR41) 2019; 157
H Huang (30392_CR57) 2013; 144
IM Stromnes (30392_CR54) 2014; 63
LJ Bayne (30392_CR55) 2012; 21
TV Pedchenko (30392_CR23) 2008; 39
TC He (30392_CR20) 1999; 99
M Kanda (30392_CR6) 2012; 142
Y Zhang (30392_CR34) 2013; 73
SR Hingorani (30392_CR28) 2003; 4
B Philip (30392_CR12) 2013; 145
D Wei (30392_CR59) 2016; 29
U Nöthlings (30392_CR8) 2005; 97
T Adhikary (30392_CR31) 2013; 32
JB Mitchem (30392_CR46) 2013; 73
D Wang (30392_CR52) 2014; 111
30392_CR19
L Badea (30392_CR63) 2008; 55
F Grizzi (30392_CR29) 2019; 17
K Movahedi (30392_CR40) 2010; 70
J Shao (30392_CR48) 2002; 62
A Abdollahi (30392_CR22) 2007; 104
AC Thiébaut (30392_CR9) 2009; 101
X Zuo (30392_CR24) 2017; 2
RB Corcoran (30392_CR35) 2011; 71
F Luo (30392_CR49) 2009; 90
B Ji (30392_CR36) 2009; 137
Y Liu (30392_CR61) 2019; 79
H Ying (30392_CR30) 2012; 149
J Daniluk (30392_CR58) 2012; 122
HH Chang (30392_CR14) 2017; 12
JS Roe (30392_CR42) 2017; 170
M Hori (30392_CR11) 2011; 40
M Tada (30392_CR50) 1996; 110
DW Dawson (30392_CR15) 2013; 6
RA Gupta (30392_CR33) 2004; 10
Z Yan (30392_CR62) 2016; 2016
JD Coleman (30392_CR25) 2013; 2013
Y Barak (30392_CR32) 2002; 99
BH Li (30392_CR56) 2020; 117
P Hou (30392_CR45) 2020; 10
References_xml – volume: 144
  start-page: 202
  year: 2013
  end-page: 210
  ident: CR57
  article-title: Activation of nuclear factor-kappaB in acinar cells increases the severity of pancreatitis in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.09.059
– volume: 122
  start-page: 1519
  year: 2012
  end-page: 1528
  ident: CR58
  article-title: An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI59743
– volume: 388
  start-page: 73
  year: 2016
  end-page: 85
  ident: CR1
  article-title: Pancreatic cancer
  publication-title: Lancet
  doi: 10.1016/S0140-6736(16)00141-0
– volume: 157
  start-page: 163
  year: 2019
  end-page: 178
  ident: CR41
  article-title: PPARD and interferon gamma promote transformation of gastric progenitor cells and tumorigenesis in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.03.018
– volume: 144
  start-page: 1220
  year: 2013
  end-page: 1229
  ident: CR7
  article-title: Roles for KRAS in pancreatic tumor development and progression
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.01.071
– volume: 16
  start-page: 996
  year: 2003
  end-page: 1006
  ident: CR4
  article-title: Clinicopathological correlates of pancreatic intraepithelial neoplasia: a comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma
  publication-title: Mod. Pathol.
  doi: 10.1097/01.MP.0000087422.24733.62
– volume: 142
  start-page: 730
  year: 2012
  end-page: 733.e739
  ident: CR6
  article-title: Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.12.042
– volume: 99
  start-page: 335
  year: 1999
  end-page: 345
  ident: CR20
  article-title: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81664-5
– volume: 220
  start-page: 470
  year: 2012
  end-page: 476
  ident: CR26
  article-title: Effects of the PPAR-delta agonist MBX-8025 on atherogenic dyslipidemia
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2011.10.029
– volume: 33
  start-page: 532
  year: 2014
  end-page: 535
  ident: CR37
  article-title: Oncogenic K-Ras requires activation for enhanced activity
  publication-title: Oncogene
  doi: 10.1038/onc.2012.619
– volume: 55
  start-page: 2016
  year: 2008
  end-page: 2027
  ident: CR63
  article-title: Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia
  publication-title: Hepatogastroenterology
– volume: 315
  start-page: G699
  year: 2018
  end-page: G712
  ident: CR17
  article-title: Dietary fat stimulates pancreatic cancer growth and promotes fibrosis of the tumor microenvironment through the cholecystokinin receptor
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00123.2018
– volume: 40
  start-page: 1234
  year: 2011
  end-page: 1240
  ident: CR11
  article-title: Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl)amine-treated hamsters by high-fat diet
  publication-title: Pancreas
  doi: 10.1097/MPA.0b013e318220e742
– volume: 21
  start-page: 822
  year: 2012
  end-page: 835
  ident: CR55
  article-title: Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.04.025
– volume: 12
  start-page: e0184455
  year: 2017
  ident: CR14
  article-title: Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0184455
– volume: 109
  start-page: 3013
  year: 2018
  end-page: 3023
  ident: CR18
  article-title: Fatty pancreas: a possible risk factor for pancreatic cancer in animals and humans
  publication-title: Cancer Sci.
  doi: 10.1111/cas.13766
– volume: 2013
  start-page: 11
  year: 2013
  ident: CR25
  article-title: Role of peroxisome proliferator-activated receptor and B-cell lymphoma-6 in regulation of genes involved in metastasis and migration in pancreatic cancer cells
  publication-title: PPAR Res.
  doi: 10.1155/2013/121956
– volume: 111
  start-page: 7084
  year: 2014
  end-page: 7089
  ident: CR52
  article-title: Peroxisome proliferator-activated receptor delta promotes colonic inflammation and tumor growth
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1324233111
– volume: 25
  start-page: 579
  year: 2001
  end-page: 586
  ident: CR2
  article-title: Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
  publication-title: Am. J. Surg. Pathol.
  doi: 10.1097/00000478-200105000-00003
– volume: 186
  start-page: 305
  year: 2017
  end-page: 317
  ident: CR10
  article-title: A cohort study of adolescent and midlife diet and pancreatic cancer risk in the nIH-AARP diet and health study
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwx036
– volume: 15
  start-page: 2000
  year: 2016
  end-page: 2011
  ident: CR39
  article-title: Reprogramming tumor-associated macrophages by antibody targeting inhibits cancer progression and metastasis
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.04.084
– volume: 19
  start-page: 3404
  year: 2013
  end-page: 3415
  ident: CR43
  article-title: Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-13-0525
– volume: 39
  start-page: 689
  year: 2008
  end-page: 696
  ident: CR23
  article-title: Peroxisome proliferator-activated receptor β/δ expression and activation in lung cancer
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2007-0426OC
– ident: CR19
– volume: 99
  start-page: 303
  year: 2002
  end-page: 308
  ident: CR32
  article-title: Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.012610299
– volume: 18
  start-page: 457
  year: 2021
  end-page: 468
  ident: CR5
  article-title: Early detection of pancreatic cancer using DNA-based molecular approaches
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-021-00470-0
– volume: 73
  start-page: 1128
  year: 2013
  end-page: 1141
  ident: CR46
  article-title: Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-2731
– volume: 137
  start-page: 1072
  year: 2009
  end-page: 1082
  ident: CR36
  article-title: Ras activity levels control the development of pancreatic diseases
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2009.05.052
– volume: 157
  start-page: 1413
  year: 2019
  end-page: 1428 e1411
  ident: CR16
  article-title: Oncogenic KRAS reduces expression of FGF21 in acinar cells to promote pancreatic tumorigenesis in mice on a high-fat diet
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.07.030
– volume: 29
  start-page: 2359
  year: 2015
  end-page: 2370
  ident: CR51
  article-title: 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway
  publication-title: FASEB J.
  doi: 10.1096/fj.14-264515
– volume: 6
  start-page: 1064
  year: 2013
  end-page: 1073
  ident: CR15
  article-title: High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model
  publication-title: Cancer Prev. Res. (Philos.)
  doi: 10.1158/1940-6207.CAPR-13-0065
– volume: 79
  start-page: 954
  year: 2019
  end-page: 969
  ident: CR61
  article-title: Pleiotropic effects of PPARD accelerate colorectal tumorigenesis, progression, and invasion
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-18-1790
– volume: 70
  start-page: 5728
  year: 2010
  end-page: 5739
  ident: CR40
  article-title: Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-4672
– volume: 63
  start-page: 1769
  year: 2014
  end-page: 1781
  ident: CR54
  article-title: Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity
  publication-title: Gut
  doi: 10.1136/gutjnl-2013-306271
– volume: 101
  start-page: 1001
  year: 2009
  end-page: 1011
  ident: CR9
  article-title: Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study
  publication-title: J. Natl Cancer Inst.
  doi: 10.1093/jnci/djp168
– volume: 2016
  start-page: 8367063
  year: 2016
  ident: CR62
  article-title: Quantitative evaluation and selection of reference genes for quantitative RT-PCR in mouse acute pancreatitis
  publication-title: Biomed. Res. Int.
– volume: 10
  start-page: 245
  year: 2004
  end-page: 247
  ident: CR33
  article-title: Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
  publication-title: Nat. Med.
  doi: 10.1038/nm993
– volume: 57
  start-page: 332
  year: 2008
  end-page: 339
  ident: CR27
  article-title: Activation of peroxisome proliferator–activated receptor (PPAR)δ promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
  publication-title: Diabetes
  doi: 10.2337/db07-1318
– volume: 110
  start-page: 227
  year: 1996
  end-page: 231
  ident: CR50
  article-title: Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
  publication-title: Gastroenterology
  doi: 10.1053/gast.1996.v110.pm8536861
– volume: 73
  start-page: 6359
  year: 2013
  end-page: 6374
  ident: CR34
  article-title: Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-13-1558-T
– volume: 117
  start-page: 201
  year: 2020
  end-page: 215
  ident: CR56
  article-title: Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2019.11.014
– volume: 2
  start-page: e91419
  year: 2017
  ident: CR24
  article-title: Metastasis regulation by PPARD expression in cancer cells
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.91419
– volume: 17
  year: 2019
  ident: CR29
  article-title: Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-019-1817-3
– volume: 90
  start-page: 558
  year: 2009
  end-page: 574
  ident: CR49
  article-title: Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways
  publication-title: Int J. Exp. Pathol.
  doi: 10.1111/j.1365-2613.2009.00667.x
– volume: 106
  start-page: 3354
  year: 2009
  end-page: 3359
  ident: CR13
  article-title: Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0802864106
– volume: 10
  start-page: 1058
  year: 2020
  end-page: 1077
  ident: CR45
  article-title: Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer
  publication-title: Cancer Disco.
  doi: 10.1158/2159-8290.CD-19-0597
– ident: CR3
– volume: 145
  start-page: 1449
  year: 2013
  end-page: 1458
  ident: CR12
  article-title: A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.08.018
– volume: 104
  start-page: 12890
  year: 2007
  end-page: 12895
  ident: CR22
  article-title: Transcriptional network governing the angiogenic switch in human pancreatic cancer
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0705505104
– ident: CR38
– volume: 29
  start-page: 324
  year: 2016
  end-page: 338
  ident: CR59
  article-title: KLF4 is essential for induction of cellular identity change and acinar-to-ductal reprogramming during early pancreatic carcinogenesis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.02.005
– volume: 97
  start-page: 13275
  year: 2000
  end-page: 13280
  ident: CR21
  article-title: Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.97.24.13275
– volume: 4
  start-page: 437
  year: 2003
  end-page: 450
  ident: CR28
  article-title: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00309-X
– volume: 170
  start-page: 875
  year: 2017
  end-page: 888.e820
  ident: CR42
  article-title: Enhancer reprogramming promotes pancreatic cancer metastasis
  publication-title: Cell
  doi: 10.1016/j.cell.2017.07.007
– volume: 97
  start-page: 1458
  year: 2005
  end-page: 1465
  ident: CR8
  article-title: Meat and fat intake as risk factors for pancreatic cancer: the multiethnic cohort study
  publication-title: J. Natl Cancer Inst.
  doi: 10.1093/jnci/dji292
– volume: 71
  start-page: 5020
  year: 2011
  end-page: 5029
  ident: CR35
  article-title: STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-0908
– volume: 62
  start-page: 3282
  year: 2002
  end-page: 3288
  ident: CR48
  article-title: Peroxisome proliferator-activated receptors modulate K-Ras-mediated transformation of intestinal epithelial cells
  publication-title: Cancer Res.
– volume: 32
  start-page: 5241
  year: 2013
  end-page: 5252
  ident: CR31
  article-title: Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion
  publication-title: Oncogene
  doi: 10.1038/onc.2012.549
– volume: 117
  start-page: 1129
  year: 2020
  end-page: 1138
  ident: CR44
  article-title: CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1910856117
– volume: 30
  start-page: 355
  year: 2016
  end-page: 385
  ident: CR53
  article-title: Genetics and biology of pancreatic ductal adenocarcinoma
  publication-title: Genes Dev.
  doi: 10.1101/gad.275776.115
– volume: 149
  start-page: 656
  year: 2012
  end-page: 670
  ident: CR30
  article-title: Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
  publication-title: Cell
  doi: 10.1016/j.cell.2012.01.058
– volume: 2
  start-page: 913
  year: 2011
  end-page: 918
  ident: CR47
  article-title: Discovery of INCB8761/PF-4136309, a potent, selective, and orally bioavailable CCR2 antagonist
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/ml200199c
– volume: 202
  start-page: 265
  year: 2004
  end-page: 273
  ident: CR60
  article-title: Immunophenotypic analysis of inflammatory breast cancers: identification of an ‘inflammatory signature’
  publication-title: J. Pathol.
  doi: 10.1002/path.1515
– volume: 2013
  start-page: 11
  year: 2013
  ident: 30392_CR25
  publication-title: PPAR Res.
  doi: 10.1155/2013/121956
– volume: 17
  year: 2019
  ident: 30392_CR29
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-019-1817-3
– volume: 144
  start-page: 1220
  year: 2013
  ident: 30392_CR7
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.01.071
– volume: 21
  start-page: 822
  year: 2012
  ident: 30392_CR55
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.04.025
– volume: 122
  start-page: 1519
  year: 2012
  ident: 30392_CR58
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI59743
– volume: 2016
  start-page: 8367063
  year: 2016
  ident: 30392_CR62
  publication-title: Biomed. Res. Int.
– volume: 101
  start-page: 1001
  year: 2009
  ident: 30392_CR9
  publication-title: J. Natl Cancer Inst.
  doi: 10.1093/jnci/djp168
– volume: 63
  start-page: 1769
  year: 2014
  ident: 30392_CR54
  publication-title: Gut
  doi: 10.1136/gutjnl-2013-306271
– volume: 10
  start-page: 245
  year: 2004
  ident: 30392_CR33
  publication-title: Nat. Med.
  doi: 10.1038/nm993
– volume: 18
  start-page: 457
  year: 2021
  ident: 30392_CR5
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-021-00470-0
– volume: 2
  start-page: e91419
  year: 2017
  ident: 30392_CR24
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.91419
– volume: 99
  start-page: 303
  year: 2002
  ident: 30392_CR32
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.012610299
– volume: 25
  start-page: 579
  year: 2001
  ident: 30392_CR2
  publication-title: Am. J. Surg. Pathol.
  doi: 10.1097/00000478-200105000-00003
– volume: 90
  start-page: 558
  year: 2009
  ident: 30392_CR49
  publication-title: Int J. Exp. Pathol.
  doi: 10.1111/j.1365-2613.2009.00667.x
– volume: 315
  start-page: G699
  year: 2018
  ident: 30392_CR17
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00123.2018
– volume: 15
  start-page: 2000
  year: 2016
  ident: 30392_CR39
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.04.084
– volume: 10
  start-page: 1058
  year: 2020
  ident: 30392_CR45
  publication-title: Cancer Disco.
  doi: 10.1158/2159-8290.CD-19-0597
– volume: 117
  start-page: 1129
  year: 2020
  ident: 30392_CR44
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1910856117
– volume: 144
  start-page: 202
  year: 2013
  ident: 30392_CR57
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.09.059
– volume: 29
  start-page: 324
  year: 2016
  ident: 30392_CR59
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.02.005
– volume: 19
  start-page: 3404
  year: 2013
  ident: 30392_CR43
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-13-0525
– volume: 110
  start-page: 227
  year: 1996
  ident: 30392_CR50
  publication-title: Gastroenterology
  doi: 10.1053/gast.1996.v110.pm8536861
– volume: 70
  start-page: 5728
  year: 2010
  ident: 30392_CR40
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-4672
– volume: 109
  start-page: 3013
  year: 2018
  ident: 30392_CR18
  publication-title: Cancer Sci.
  doi: 10.1111/cas.13766
– volume: 6
  start-page: 1064
  year: 2013
  ident: 30392_CR15
  publication-title: Cancer Prev. Res. (Philos.)
  doi: 10.1158/1940-6207.CAPR-13-0065
– ident: 30392_CR38
  doi: 10.1084/jem.20201803
– volume: 71
  start-page: 5020
  year: 2011
  ident: 30392_CR35
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-0908
– volume: 142
  start-page: 730
  year: 2012
  ident: 30392_CR6
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.12.042
– volume: 30
  start-page: 355
  year: 2016
  ident: 30392_CR53
  publication-title: Genes Dev.
  doi: 10.1101/gad.275776.115
– volume: 186
  start-page: 305
  year: 2017
  ident: 30392_CR10
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwx036
– volume: 111
  start-page: 7084
  year: 2014
  ident: 30392_CR52
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1324233111
– volume: 220
  start-page: 470
  year: 2012
  ident: 30392_CR26
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2011.10.029
– volume: 97
  start-page: 13275
  year: 2000
  ident: 30392_CR21
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.97.24.13275
– volume: 33
  start-page: 532
  year: 2014
  ident: 30392_CR37
  publication-title: Oncogene
  doi: 10.1038/onc.2012.619
– volume: 55
  start-page: 2016
  year: 2008
  ident: 30392_CR63
  publication-title: Hepatogastroenterology
– ident: 30392_CR3
  doi: 10.1097/MPA.0000000000000786
– volume: 106
  start-page: 3354
  year: 2009
  ident: 30392_CR13
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0802864106
– volume: 202
  start-page: 265
  year: 2004
  ident: 30392_CR60
  publication-title: J. Pathol.
  doi: 10.1002/path.1515
– volume: 79
  start-page: 954
  year: 2019
  ident: 30392_CR61
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-18-1790
– volume: 388
  start-page: 73
  year: 2016
  ident: 30392_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(16)00141-0
– volume: 16
  start-page: 996
  year: 2003
  ident: 30392_CR4
  publication-title: Mod. Pathol.
  doi: 10.1097/01.MP.0000087422.24733.62
– volume: 12
  start-page: e0184455
  year: 2017
  ident: 30392_CR14
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0184455
– volume: 145
  start-page: 1449
  year: 2013
  ident: 30392_CR12
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.08.018
– volume: 57
  start-page: 332
  year: 2008
  ident: 30392_CR27
  publication-title: Diabetes
  doi: 10.2337/db07-1318
– volume: 73
  start-page: 6359
  year: 2013
  ident: 30392_CR34
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-13-1558-T
– volume: 104
  start-page: 12890
  year: 2007
  ident: 30392_CR22
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0705505104
– volume: 32
  start-page: 5241
  year: 2013
  ident: 30392_CR31
  publication-title: Oncogene
  doi: 10.1038/onc.2012.549
– volume: 39
  start-page: 689
  year: 2008
  ident: 30392_CR23
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2007-0426OC
– volume: 149
  start-page: 656
  year: 2012
  ident: 30392_CR30
  publication-title: Cell
  doi: 10.1016/j.cell.2012.01.058
– volume: 4
  start-page: 437
  year: 2003
  ident: 30392_CR28
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00309-X
– volume: 73
  start-page: 1128
  year: 2013
  ident: 30392_CR46
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-2731
– volume: 2
  start-page: 913
  year: 2011
  ident: 30392_CR47
  publication-title: ACS Med. Chem. Lett.
  doi: 10.1021/ml200199c
– volume: 62
  start-page: 3282
  year: 2002
  ident: 30392_CR48
  publication-title: Cancer Res.
– volume: 99
  start-page: 335
  year: 1999
  ident: 30392_CR20
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81664-5
– volume: 40
  start-page: 1234
  year: 2011
  ident: 30392_CR11
  publication-title: Pancreas
  doi: 10.1097/MPA.0b013e318220e742
– volume: 170
  start-page: 875
  year: 2017
  ident: 30392_CR42
  publication-title: Cell
  doi: 10.1016/j.cell.2017.07.007
– volume: 29
  start-page: 2359
  year: 2015
  ident: 30392_CR51
  publication-title: FASEB J.
  doi: 10.1096/fj.14-264515
– volume: 117
  start-page: 201
  year: 2020
  ident: 30392_CR56
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2019.11.014
– volume: 157
  start-page: 1413
  year: 2019
  ident: 30392_CR16
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.07.030
– volume: 137
  start-page: 1072
  year: 2009
  ident: 30392_CR36
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2009.05.052
– ident: 30392_CR19
  doi: 10.3390/ijms19113339
– volume: 97
  start-page: 1458
  year: 2005
  ident: 30392_CR8
  publication-title: J. Natl Cancer Inst.
  doi: 10.1093/jnci/dji292
– volume: 157
  start-page: 163
  year: 2019
  ident: 30392_CR41
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.03.018
SSID ssj0000391844
Score 2.5597975
Snippet Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with...
Pancreatic intraepithelial neoplasia (PanIN) can develop into pancreatic ductal adenocarcinoma (PDAC), however, the factors which determine how this occurs are...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2665
SubjectTerms 13
13/106
13/44
14/1
14/105
14/63
42/89
49
49/91
631/67/1504/1713
631/67/2327
631/67/327
631/67/69
631/67/70
64/60
Adenocarcinoma
Aging
Animals
Cancer
Carcinogenesis
Carcinogenesis - genetics
Carcinogenesis - pathology
Carcinogens
Carcinoma in Situ - pathology
Carcinoma, Pancreatic Ductal - pathology
CC chemokine receptors
CCR2 protein
Epithelial cells
Epithelium
High fat diet
Humanities and Social Sciences
Humans
K-Ras protein
Ligands
Lipids
Macrophages
Mice
Monocyte chemoattractant protein 1
multidisciplinary
Mutants
Mutation
Pancreas
Pancreas - pathology
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - pathology
PPAR delta - genetics
Proto-Oncogene Proteins p21(ras) - genetics
Receptors
Science
Science (multidisciplinary)
Suppressor cells
Tumor microenvironment
Tumor Microenvironment - genetics
Tumorigenesis
Tumors
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlUOil9F2naVGht9bEluSVddyGhJBACdsGchN6jFpD1w6760L-V39Hf1NHsne72-elFx8sCYmZ0cwnNPqGkFdFZZnzocxBWZ4LUD43yrIcXAWO4dfZxPb5bnJ6Kc6uqqutUl8xJ2ygBx4EdygdoAO1QkEQgslQFxKs52ISvJmoOpFtY8zbOkwlH8wVHl3E-Eqm4PXhUiSfkJLXsRVh5U4kSoT9v0OZvyZL_nRjmgLRyT1yd0SQdDqs_D65Be0DcnuoKXnzkPQzc914apzDgDKol3aBns-m7_N5H2sGU3QAA1Z01MVSQm33MXq8Zkm_NIYuIFXHwbnjuFU_7xa0ia9IgM5j9t7W0zhqb-jFxXT27esjcnly_OHoNB9rK-QOMdoqNxyK0ktumTeeSxlCsAaUcZEAy4WKKes8oGSZF7I2JjBRgUGRFqhD4J4_Jntt18JTQjEOhrKUpna-wnhvUFfGmgjVwAT0Hxkp13LWbiQej_UvPut0Ac5rPehGo2500o2WGXm9GXM90G78tffbqL5Nz0iZnX6gIenRkPS_DCkjB2vl63EfLzXCF45n0kLhHC83zbgD47WKaaHrU5_4Lh_BakaeDLayWQmiuUnMO8qI3LGinaXutrTNp8TyrSK5X4kj36zt7cey_iyK_f8himfkDosbJZLU8gOyt1r08Byx18q-SNvsO2X_Ldc
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lj9MwELZgERIXxJssCzISN4g2sZ04OaGCKCuQ0Kqw0t4sP5dINOm2DdL-L34Hv4kZJ-1SHnvJoR4rrscz88Uef0PIi6wwzLqQp742PBW-dqmuDUu9Lbxl8LQmsn1-Ko9OxIfT4nTccFuNaZUbnxgdtess7pEfQiDh8HWQ1fL14jzFqlF4ujqW0LhObuQggCld1fT9do8F2c8rIca7MhmvDlcieoaYwg6tAC534lGk7f8X1vw7ZfKPc9MYjqZ3yO0RR9LJoPi75Jpv75GbQ2XJi_ukn-lF46i2FsLKoGTaBfpxNvmcznusHEzBDQyI0VKLBYXa7gz9XrOi3xtNlz7WyIF3Y791P--WtMG7JJ7OMYfvtwty1FzQ4-PJ7OePB-Rk-u7L26N0rLCQWkBq61Rzn-VOcsOcdlzKEILRvtYWabBsKFhtrPMsq5kTstI6MFF4DVOagSY9d_wh2Wu71j8mFKJhyHOpK-sKiPraiFobjYDN6wBeJCH5Zp6VHenHsQrGNxWPwXmlBt0o0I2KulEyIS-3fRYD-caV0m9QfVtJJM6OP3TLMzXaoZLWQzyGwfkgBJOhyqQ3josyOF3WVZmQg43y1WjNK3W59hLyfNsMdoiHK7r1XR9l8HY-QNaEPBrWynYkgOlKzD5KiNxZRTtD3W1pm6-R67tGir8cer7arLfLYf1_Kvav_hdPyC2GJoAktPyA7K2XvX8K2GptnkUD-gU-SiUR
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bi9UwEA7rLoIv4t3qKhF802KbpE3zWMVlOYIsZ13Yt5DrWvC0yzmnwv4vf4e_yUl60aOr4Esf2oQOmZnM12bmG4ReZoUmxvo8dULTlDlhUyU0SZ0pnCFwNTqyfX4sj8_Y4rw430NkqoWJSfuR0jJu01N22JsNiy4dc88ziOkpv4EOAlU72PZBXS9OF_OflcB5XjE2VshktLpm8k4UimT91yHMPxMlfzstjUHo6A66PaJHXA_y3kV7rr2Hbg79JK_uo36pLhuLlTEQTAbV4s7jD8v6NF31oV8wBucfcKLBJrQRaruLsNs1G_y1UXjtYmcceHeYt-1X3Ro3oYLE4VXI3PulLA7rK3xyUi-_f3uAzo7ef3p3nI59FVID-GybKuqy3HKqiVWWcu6918oJZQL5lfEFEdpYRzJBLOOVUp6wwilY0gz056ilD9F-27XuMcIQA32ec1UZW0CsV5oJpVWAaU552DsSlE_rLM1IOh56X3yR8fCbVnLQjQTdyKgbyRP0ap5zOVBu_HP026C-eWSgy443uvWFHM1HcuMgCoNwzjNGuK8y7rSlrPRWlaIqE3Q4KV-OPryRAF0ofI9mAt7xYn4M3heOVFTruj6OCTX5AFQT9GiwlVkSQHJlyDlKEN-xoh1Rd5-0zefI8C0CsV8OM19P9vZTrL8vxZP_G_4U3SLBJQIVLT1E-9t1754Bwtrq56NL_QA-3iQi
  priority: 102
  providerName: Springer Nature
Title Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ
URI https://link.springer.com/article/10.1038/s41467-022-30392-7
https://www.ncbi.nlm.nih.gov/pubmed/35562376
https://www.proquest.com/docview/2663828097
https://www.proquest.com/docview/2664807009
https://pubmed.ncbi.nlm.nih.gov/PMC9106716
https://doaj.org/article/7ce847b49ef4427f807ebd346fda6986
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELb2IdBeEG8KS2UkbhBI4iSODwhlqy2rIlZVl0q9RX4ukbbJ0jaI_i9-B7-JsZMUCoUDl0SKbdnyzHg-x575EHruxyKUygSeZoJ4kWbK40yEnpaxliE8pXDZPs-Ts2k0msWzPdTRHbUTuNy5tbN8UtPF1auvn9dvweDfNCHj6etl5Mzd3Uv3wd97dB8dgmeiltHgQwv33cpMGGxoojZ2ZnfTI3QTXHBiL4tsuSqX0X8XDP3zNuVvR6rOUw1vo1stxMRZoxN30J4u76IbDenk-h6qJ_y6UJhLCR6nkT-uDH4_yS68eW1JhTGsEA2YlFharqGyurRLYrHEXwqOF9rR50Dftt2qnlcLXNgwE43n9nrfL7FzWKzxeJxNvn-7j6bD04-DM68lX_AkgLiVx4n2A0WJCBVXhFJjjOCacWkzZEkTh0xIpUOfhSqiKecmjGLNYXZ9ELImijxAB2VV6kcIg6M0QUB5KlUMgICLiHHBLZbT3MAC00NBN8-5bDOTW4KMq9ydkJM0b8SUg5hyJ6ac9tCLTZvrJi_HP2ufWPFtatqc2u5DtbjMWxPNqdTgqmFw2kRRSE3qUy0UiRKjeMLSpIeOO-HnnZ7mgG8IbFp9Bn082xSDidpzF17qqnZ1bOA-oNkeetjoymYkna71EN3Soq2hbpeUxSeXBpzZ7H8BtHzZ6dvPYf19Kh7_d0dP0FFoDcWmriXH6GC1qPVTQGQr0Uf7dEbhmQ7f9dFhlo0uRvA-OT0fT-DrIBn03b-OvjPHH7mJPEU
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Jb9NAFB6VIgQXxI6hwCDBCazaM3bGPiAUlpCSUlWhlXpzZy2RiB2ygPKnOPE7-E28N7ZTwtJbLzl4ZpzxvO2zZ973CHkSpYpp4-LQ5oqHic1NKHPFQqtTqxn8auXZPvc6_cPk_VF6tEG-t7kweKyy9YneUZtK4zfybQgkHN4Ooly8nHwJsWoU7q62JTRqtRjY5Td4ZZu92HkD8n3KWO_twet-2FQVCDWgk3kouY1iI7hiRhouhHNOSZtLjdRP2qUsV9pYFuXMJCKT0rEktTJLANlYbbnhcN8L5GLCIZJjZnrv3eqbDrKtQ8cmNyfi2fYs8Z7IH5mHVgCza_HPlwn4F7b9-4jmH_u0Pvz1rpGrDW6l3VrRrpMNW94gl-pKlsubZDGUk5GhUmsIY7VS0crRwbD7MRwvsFIxBbdTI1RNNRYwKqsT9LOjGf06knRqfU0e-G8cN1-MqykdYe6KpWM8M_hbQh5VS7q_3x3-_HGLHJ7L2t8mm2VV2ruEQvR1cSxkpk0KKEOqJJdKIkC00oHXCkjcrnOhG7pzrLrxufDb7jwratkUIJvCy6YQAXm2GjOpyT7O7P0KxbfqiUTd_kI1PSkauy-EthD_YXLWJQkTLouEVYYnHWdkJ886AdlqhV803mNWnOp6QB6vmsHucTNHlrZa-D7IBgAQOSB3al1ZzQQwZAdPOwVErGnR2lTXW8rRJ88tniOlYAwjn7f6djqt_y_FvbOf4hG53D_4sFvs7uwN7pMrDM0BCXD5FtmcTxf2AeC6uXrojYmS4_O23l-S32Q9
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lj9MwELaWrkBcEG8CCxgJThBt4yR1ckCoy261S1FVFVbam9fPpRJNSh-g_i9O_Ah-EzNO0qU89raXHGI7cTzjmc_x-BtCnrdTxbRxUWhzFYeJzU0oc8VCq1OrGVy18myfg87hcfLuJD3ZIj-aszAYVtnYRG-oTanxH_kuOJIYVgdIuOjqsIjhfu_N9EuIGaRwp7VJp1GpSN-uvsHybf76aB9k_YKx3sHHt4dhnWEg1IBUFqGMbTsyPFbMSBNz7pxT0uZSIw2UdinLlTaWtXNmEp5J6ViSWpklgHKstrGJ4blXyDbHVVGLbO8dDIaj9R8e5F6HqvVJnXac7c4Tb5d8AD2UArTd8IY-acC_kO7fAZt_7Np6Z9i7SW7UKJZ2K7W7RbZscZtcrfJaru6Q5UhOx4ZKrcGpVSpGS0f7o-6HcLLEvMUUjFCFVzXVmM6oKM_Q6o7n9OtY0pn1GXrg3dhusZyUMzrGkyyWTjCC8LfjeVSt6HDYHf38fpccX8ro3yOtoizsA0LBF7so4jLTJgXMIVWSSyURLlrpwIYFJGrGWeia_BxzcHwWfhM-zkQlGwGyEV42ggfk5brNtKL-uLD2HopvXRNpu_2NcnYmaisguLaABqBz1iUJ4y5rc6tMnHSckZ086wRkpxG-qG3JXJxrfkCerYvBCuDWjixsufR1kBsAAHNA7le6su4JIMoOxj4FhG9o0UZXN0uK8SfPNJ4jwWAELV81-nberf8PxcOLv-IpuQYzV7w_GvQfkesMZwOy4cY7pLWYLe1jAHkL9aSeTZScXvYE_gXth2nP
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rapid+acceleration+of+KRAS-mutant+pancreatic+carcinogenesis+via+remodeling+of+tumor+immune+microenvironment+by+PPAR%CE%B4&rft.jtitle=Nature+communications&rft.au=Liu%2C+Yi&rft.au=Deguchi%2C+Yasunori&rft.au=Wei%2C+Daoyan&rft.au=Liu%2C+Fuyao&rft.date=2022-05-13&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=13&rft_id=info:doi/10.1038%2Fs41467-022-30392-7&rft_id=info%3Apmid%2F35562376&rft.externalDocID=PMC9106716
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon