Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

• Published in: Nature communications Vol. 13; no. 1; pp. 5926 - 13
• Main Authors: Bernard-Raichon, Lucie, Venzon, Mericien, Klein, Jon, Axelrad, Jordan E., Zhang, Chenzhen, Sullivan, Alexis P., Hussey, Grant A., Casanovas-Massana, Arnau, Noval, Maria G., Valero-Jimenez, Ana M., Gago, Juan, Putzel, Gregory, Pironti, Alejandro, Wilder, Evan, Thorpe, Lorna E., Littman, Dan R., Dittmann, Meike, Stapleford, Kenneth A., Shopsin, Bo, Torres, Victor J., Ko, Albert I., Iwasaki, Akiko, Cadwell, Ken, Schluter, Jonas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 38/23; 38/43; 38/77; 631/326/2522; 631/326/2565/2134; 64/110; Animals; Anti-Bacterial Agents; Antibiotics; Antiinfectives and antibacterials; Bacteremia; Bacteria; Blood; Blood culture; Cell culture; Coinfection; Coronaviruses; COVID-19; Digestive system; Dysbacteriosis; Dysbiosis - microbiology; Epithelial cells; Epithelium; Gastrointestinal Microbiome; Goblet cells; Gut microbiota; Humanities and Social Sciences; Infections; Intestinal microflora; Mice; Microbiomes; Microbiota; Microorganisms; multidisciplinary; Paneth cells; Patients; Permeability; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Translocation

Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-thr...