Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-thr...

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Published inNature communications Vol. 13; no. 1; pp. 5926 - 13
Main Authors Bernard-Raichon, Lucie, Venzon, Mericien, Klein, Jon, Axelrad, Jordan E., Zhang, Chenzhen, Sullivan, Alexis P., Hussey, Grant A., Casanovas-Massana, Arnau, Noval, Maria G., Valero-Jimenez, Ana M., Gago, Juan, Putzel, Gregory, Pironti, Alejandro, Wilder, Evan, Thorpe, Lorna E., Littman, Dan R., Dittmann, Meike, Stapleford, Kenneth A., Shopsin, Bo, Torres, Victor J., Ko, Albert I., Iwasaki, Akiko, Cadwell, Ken, Schluter, Jonas
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.11.2022
Nature Publishing Group
Nature Portfolio
Subjects
13/51
38/23
38/43
38/77
631/326/2522
631/326/2565/2134
64/110
Animals
Anti-Bacterial Agents
Antibiotics
Antiinfectives and antibacterials
Bacteremia
Bacteria
Blood
Blood culture
Cell culture
Coinfection
Coronaviruses
COVID-19
Digestive system
Dysbacteriosis
Dysbiosis - microbiology
Epithelial cells
Epithelium
Gastrointestinal Microbiome
Goblet cells
Gut microbiota
Humanities and Social Sciences
Infections
Intestinal microflora
Mice
Microbiomes
Microbiota
Microorganisms
multidisciplinary
Paneth cells
Patients
Permeability
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Translocation
Online AccessGet full text

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Abstract Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19. Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in COVID-19 patients with blood stream infections, matching reads of bacterial sequences from stool samples to organisms found in the blood.
AbstractList Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19.Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19.
Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in COVID-19 patients with blood stream infections, matching reads of bacterial sequences from stool samples to organisms found in the blood.
Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19.
Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19.Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in COVID-19 patients with blood stream infections, matching reads of bacterial sequences from stool samples to organisms found in the blood.
Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is associated with translocation of bacteria into the blood during COVID-19, causing life-threatening secondary infections. We first demonstrate SARS-CoV-2 infection induces gut microbiome dysbiosis in mice, which correlated with alterations to Paneth cells and goblet cells, and markers of barrier permeability. Samples collected from 96 COVID-19 patients at two different clinical sites also revealed substantial gut microbiome dysbiosis, including blooms of opportunistic pathogenic bacterial genera known to include antimicrobial-resistant species. Analysis of blood culture results testing for secondary microbial bloodstream infections with paired microbiome data indicates that bacteria may translocate from the gut into the systemic circulation of COVID-19 patients. These results are consistent with a direct role for gut microbiome dysbiosis in enabling dangerous secondary infections during COVID-19. Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in COVID-19 patients with blood stream infections, matching reads of bacterial sequences from stool samples to organisms found in the blood.
ArticleNumber 5926
Author Ko, Albert I.
Sullivan, Alexis P.
Valero-Jimenez, Ana M.
Pironti, Alejandro
Shopsin, Bo
Zhang, Chenzhen
Cadwell, Ken
Dittmann, Meike
Axelrad, Jordan E.
Hussey, Grant A.
Casanovas-Massana, Arnau
Stapleford, Kenneth A.
Noval, Maria G.
Wilder, Evan
Klein, Jon
Putzel, Gregory
Thorpe, Lorna E.
Torres, Victor J.
Venzon, Mericien
Gago, Juan
Bernard-Raichon, Lucie
Schluter, Jonas
Littman, Dan R.
Iwasaki, Akiko
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36319618$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Contributor Martin, Anjelica
Linehan, Melissa
McDonald, David
Smolgovsky, Mikhail
Naushad, Nida
Courchaine, Edward
Batsu, Maria
Nouws, Jessica
Geng, Bertie
Sewanan, Lorenzo
Campbell, Melissa
Watkins, Annie
Brower, Kristina
Rahming, Harold
Valdez, Jordan
Lim, Joseph
White, Elizabeth B
Simonov, Michael
Kim, Daniel
Park, Hong-Jai
Glick, Laura
Anastasio, Kelly
Sonnert, Nicole
Sharma, Lokesh
Matos, Irene
Prophet, Sarah
Knaggs, Lynda
Song, Eric
Martinello, Rick
Nelson, Allison
Khoury-Hanold, William
Peng, Xiaohua
DeIuliis, Giuseppe
Shepard, Denise
Cao, Yiyun
Kalinich, Chaney
Rose, Kadi-Ann
Handoko, Ryan
Obaid, Abeer
Bermejo, Santos
Lu-Culligan, Alice
Todeasa, Codruta
Jensen, Cole
Bickerton, Sean
Fauver, Joseph
Kuang, Maxine
Alpert, Tara
Silva, Erin
Strong, Yvette
Askenase, Michael H
Datta, Rupak
Yang, Yexin
Velazquez, Sofia
Kudo, Eriko
Nunez, Angela
Nakahata, Maura
Rice, Tyler
Vijayakumar, Pavithra
Brito, Anderson
Minasyan, Maksym
Harden, Christina
Petrone, Mary
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– reference: 35262080 - bioRxiv. 2022 Mar 02;:
– reference: 34341786 - Res Sq. 2021 Jul 27;:
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Snippet Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we...
Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis...
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38/23
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631/326/2522
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64/110
Animals
Anti-Bacterial Agents
Antibiotics
Antiinfectives and antibacterials
Bacteremia
Bacteria
Blood
Blood culture
Cell culture
Coinfection
Coronaviruses
COVID-19
Digestive system
Dysbacteriosis
Dysbiosis - microbiology
Epithelial cells
Epithelium
Gastrointestinal Microbiome
Goblet cells
Gut microbiota
Humanities and Social Sciences
Infections
Intestinal microflora
Mice
Microbiomes
Microbiota
Microorganisms
multidisciplinary
Paneth cells
Patients
Permeability
SARS-CoV-2
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Translocation
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Title Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia
URI https://link.springer.com/article/10.1038/s41467-022-33395-6
https://www.ncbi.nlm.nih.gov/pubmed/36319618
https://www.proquest.com/docview/2730909560
https://www.proquest.com/docview/2731430476
https://pubmed.ncbi.nlm.nih.gov/PMC9626559
https://doaj.org/article/1e9e329dabff4d05a3ee9e3f9ac67097
Volume 13
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