USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy - Xiong, Wenjun; Gao, Xueliang; Zhang, Tiantian; Jiang, Baishan; Hu, Ming-Ming; Bu, Xia; Gao, Yang; Zhang, Lin-Zhou; Xiao, Bo-Lin; He, Chuan; Sun, Yishuang; Li, Haiou; et al. (Nature communications, 2022)
Keywords: 13/31; 38/88; 45/90; 45/91; 631/337/458/582; 631/67/327; 64/60; Animal models; Animals; Anticancer properties; CD8 antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Endopeptidases - genetics; Endosomal Sorting Complexes Required for Transport - genetics; Humanities and Social Sciences; Humans; Immune response; Immune system; Immunotherapy; Inflammation; Inhibitors; Innate immunity; L1 protein; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Mice; multidisciplinary; Neoplasms - drug therapy; Neoplasms - genetics; NF-κB protein; PD-1 protein; PD-L1 protein; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Proteins; Regulatory mechanisms (biology); Science; Science (multidisciplinary); Signaling; TRAF6 protein; Tumor Microenvironment; Tumors; Ubiquitin Thiolesterase - antagonists & inhibitors; Ubiquitin Thiolesterase - genetics; Ubiquitination