Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures

• Published in: Nature communications Vol. 12; no. 1; pp. 1647 - 14
• Main Authors: Li, Jiao, Seidlitz, Jakob, Suckling, John, Fan, Feiyang, Ji, Gong-Jun, Meng, Yao, Yang, Siqi, Wang, Kai, Qiu, Jiang, Chen, Huafu, Liao, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 38/61; 59/57; 631/208/191/2018; 631/378/1689/1414; 692/698/1688/64; Abnormalities; Adult; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain - pathology; Brain Mapping; Correlation analysis; Depressive Disorder, Major - genetics; Depressive Disorder, Major - metabolism; Female; Gene expression; Gene Expression Regulation; Genes; Humanities and Social Sciences; Humans; Male; Medical imaging; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Mental depression; Microfilament Proteins - genetics; Microfilament Proteins - metabolism; Microglia; Middle Aged; multidisciplinary; Neuroimaging; Neuroimaging - methods; Neurons; Science; Science (multidisciplinary); Transcription; Transcriptome

Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene expression is unclear. Here, we examine the link between brain-wide gene expression...