Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis

• Published in: Nature communications Vol. 12; no. 1; pp. 4814 - 13
• Main Authors: Bodineau, Clément, Tomé, Mercedes, Courtois, Sarah, Costa, Ana S. H., Sciacovelli, Marco, Rousseau, Benoit, Richard, Elodie, Vacher, Pierre, Parejo-Pérez, Carlos, Bessede, Emilie, Varon, Christine, Soubeyran, Pierre, Frezza, Christian, Murdoch, Piedad del Socorro, Villar, Victor H., Durán, Raúl V.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 14; 14/19; 631/45/320; 631/80/82/23; 631/80/86/2369; 64; 64/60; 82/51; 96; 96/106; 96/2; 96/31; Adenosine Triphosphate - metabolism; Amino acids; AMP-Activated Protein Kinases - metabolism; Animals; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - physiology; Asparagine; ATP; Bioenergetics; Cancer; Cell death; Cell Line, Tumor; Cell Proliferation - physiology; Glutamine; Glutamine - metabolism; HCT116 Cells; HEK293 Cells; Humanities and Social Sciences; Humans; Ketoglutaric acid; Male; Mechanistic Target of Rapamycin Complex 1 - metabolism; Metabolism; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; multidisciplinary; Science; Science (multidisciplinary); Signal Transduction - physiology; Sirolimus - analogs & derivatives; Sirolimus - pharmacology; Xenograft Model Antitumor Assays - methods; γ-Aminobutyric acid

Glutamoptosis is the induction of apoptotic cell death as a consequence of the aberrant activation of glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role of the bioenergetic sensor AMPK during glutamoptosis is not defined yet. Here, we show that AMPK rea...