Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B me...
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Published in | npj vaccines Vol. 6; no. 1; p. 130 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Nature Publishing Group UK
29.10.2021
Nature Publishing Group Nature Portfolio |
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Abstract | Infections with
Neisseria meningitidis
and
Neisseria gonorrhoeae
have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and
N. gonorrhoeae
. Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease. |
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AbstractList | Infections with
Neisseria meningitidis
and
Neisseria gonorrhoeae
have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and
N. gonorrhoeae
. Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease. Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae. Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease. |
ArticleNumber | 130 |
Author | Vázquez, Julio A. Seib, Kate L. de Lemos, Ana Paula S. Taha, Muhamed-Kheir Pizza, Mariagrazia Ruiz García, Yara Bekkat-Berkani, Rafik Sohn, Woo-Yun Rappuoli, Rino Vadivelu, Kumaran |
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Snippet | Infections with
Neisseria meningitidis
and
Neisseria gonorrhoeae
have different clinical manifestations, but the bacteria share up to 80–90% genome sequence... Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80-90% genome sequence... Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence... |
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SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
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SubjectTerms | 631/250/255/1318 631/250/590/2294 Antigens Bacterial infections Biomedical and Life Sciences Biomedicine Genotype & phenotype Gonorrhea Immunization Infectious Diseases Medical Microbiology Meningitis Public Health Review Review Article Sexually transmitted diseases STD Vaccine Vaccines Virology |
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Title | Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect |
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