Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect

Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B me...

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Published innpj vaccines Vol. 6; no. 1; p. 130
Main Authors Ruiz García, Yara, Sohn, Woo-Yun, Seib, Kate L., Taha, Muhamed-Kheir, Vázquez, Julio A., de Lemos, Ana Paula S., Vadivelu, Kumaran, Pizza, Mariagrazia, Rappuoli, Rino, Bekkat-Berkani, Rafik
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 29.10.2021
Nature Publishing Group
Nature Portfolio
Subjects
631/250/255/1318
631/250/590/2294
Antigens
Bacterial infections
Biomedical and Life Sciences
Biomedicine
Genotype & phenotype
Gonorrhea
Immunization
Infectious Diseases
Medical Microbiology
Meningitis
Public Health
Review
Review Article
Sexually transmitted diseases
STD
Vaccine
Vaccines
Virology
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Abstract Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae . Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease.
AbstractList Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae . Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease.
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae. Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease.
ArticleNumber 130
Author Vázquez, Julio A.
Seib, Kate L.
de Lemos, Ana Paula S.
Taha, Muhamed-Kheir
Pizza, Mariagrazia
Ruiz García, Yara
Bekkat-Berkani, Rafik
Sohn, Woo-Yun
Rappuoli, Rino
Vadivelu, Kumaran
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Cites_doi 10.1371/journal.ppat.1008602
10.1080/21645515.2020.1855951
10.1371/journal.pone.0116024
10.1093/cid/ciaa1244
10.1016/j.vaccine.2011.04.092
10.1016/j.vaccine.2010.12.075
10.1136/sextrans-2015-052378
10.1056/NEJM200105033441807
10.1001/jama.2020.20449
10.1038/s41572-019-0128-6
10.1186/s12866-015-0469-6
10.3201/eid2202.150369
10.1080/21645515.2017.1264750
10.1016/j.jinf.2020.07.034
10.1016/j.jinf.2017.05.015
10.1016/j.vaccine.2012.12.022
10.2471/BLT.18.228486
10.1093/cid/ciy1061
10.1111/1469-0691.12647
10.1128/mBio.01668-19
10.1001/jama.2021.3370
10.1080/21645515.2018.1451810
10.4049/jimmunol.138.12.4402
10.1073/pnas.0603940103
10.1111/j.1600-0463.2012.02903.x
10.1126/science.287.5459.1816
10.1086/315801
10.1097/INF.0000000000003047
10.4161/hv.24129
10.3201/eid2206.151093
10.1080/21645515.2020.1827614
10.1128/JCM.02161-20
10.1080/14760584.2018.1547637
10.1016/S0140-6736(17)31449-6
10.3201/eid2404.171480
10.3389/fimmu.2019.00751
10.1128/IAI.70.12.7063-7072.2002
10.2105/AJPH.2014.302044
10.1097/OLQ.0000000000001346
10.1038/mi.2007.19
10.1073/pnas.93.20.11109
10.1016/j.jinf.2021.04.031
10.1016/j.vaccine.2020.05.071
10.1016/j.mib.2014.11.006
10.1038/mi.2017.11
10.1093/ofid/ofx180.002
10.1016/j.vaccine.2012.01.033
10.1097/INF.0000000000002957
10.1096/fj.201902795R
10.1007/s40121-020-00370-x
10.1038/s41598-018-22057-7
10.1086/648966
10.1080/14760584.2017.1258308
10.1016/S0140-6736(83)90340-9
10.1016/j.vaccine.2020.09.050
10.3390/vaccines7010005
10.1126/science.287.5459.1809
10.1073/pnas.1521142113
10.1093/cid/cix154
10.1093/femspd/ftx033
10.3390/vaccines8020219
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References Rodrigues (CR36) 2018; 24
De Wals (CR59) 2017; 64
Pizza, Rappuoli (CR32) 2015; 23
Pérez (CR50) 2009; 18
Borrow (CR10) 2017; 16
Petousis-Harris (CR53) 2017; 390
Ladhani (CR41) 2016; 22
Law (CR33) 2015; 15
Perez-Trallero, Esnal, Marimon (CR34) 2014; 9
Hafner, Beagley, Timms (CR63) 2008; 1
Whelan, Kløvstad, Haugen, Holle, Storsaeter (CR51) 2016; 22
Rowley (CR8) 2019; 97
Bianchi, Fantoni, Prugnola (CR35) 2015; 56
Biagini (CR23) 2016; 113
Giuliani (CR18) 2006; 103
Abara (CR60) 2020; 47
Rosenstein, Perkins, Stephens, Popovic, Hughes (CR5) 2001; 344
Leduc (CR57) 2020; 16
Granoff (CR14) 2010; 50
Lucidarme (CR38) 2017; 75
Biolchi (CR46) 2021; 40
Read (CR6) 2014; 20
Rodrigues (CR44) 2020; 59
Ladhani (CR48) 2020; 73
Leo (CR37) 2020; 38
Rubin (CR45) 2021; 325
Tettelin (CR21) 2000; 287
Biolchi (CR31) 2020; 38
Plante (CR55) 2000; 182
Finne, Bitter-Suermann, Goridis, Finne (CR11) 1987; 138
Wang (CR24) 2011; 29
Martinón-Torres (CR47) 2021; 83
Dretler, Rouphael, Stephens (CR9) 2018; 14
Liu (CR56) 2017; 10
Masignani, Pizza, Moxon (CR12) 2019; 10
CR19
Marjuki (CR28) 2019; 10
Semchenko, Tan, Borrow, Seib (CR30) 2019; 69
Biolchi (CR39) 2021; 10
Hadad (CR3) 2012; 120
Unemo (CR4) 2019; 5
Pizza (CR20) 2000; 287
Perrin (CR2) 2002; 70
McElligott (CR7) 2014; 104
Finne, Leinonen, Mäkelä (CR13) 1983; 2
Reyes Díaz (CR52) 2021; 40
Serruto, Bottomley, Ram, Giuliani, Rappuoli (CR16) 2012; 30
Hong (CR42) 2013; 31
Paynter (CR54) 2019; 7
Natali (CR26) 2020; 34
Holst (CR15) 2013; 9
Vu, Wong, Granoff (CR25) 2011; 29
CR29
Giuliani (CR27) 2018; 8
Donald (CR17) 2017; 13
Marshall (CR62) 2021; 17
Longtin (CR58) 2017; 4
Rappuoli, Pizza, Masignani, Vadivelu (CR22) 2018; 17
Abara (CR61) 2021; 48
Tinsley, Nassif (CR1) 1996; 93
Semchenko, Seib (CR64) 2016; 92
Borrow (CR43) 2020; 81
Fazio (CR40) 2021; 17
Rodrigues (CR49) 2020; 324
388_CR19
M Biagini (388_CR23) 2016; 113
F Martinón-Torres (388_CR47) 2021; 83
J Finne (388_CR13) 1983; 2
LM Reyes Díaz (388_CR52) 2021; 40
RC Read (388_CR6) 2014; 20
E Hong (388_CR42) 2013; 31
CMC Rodrigues (388_CR36) 2018; 24
J Lucidarme (388_CR38) 2017; 75
FMP Rodrigues (388_CR49) 2020; 324
SN Ladhani (388_CR41) 2016; 22
R Borrow (388_CR10) 2017; 16
J Whelan (388_CR51) 2016; 22
D Serruto (388_CR16) 2012; 30
M Giuliani (388_CR27) 2018; 8
RGK Donald (388_CR17) 2017; 13
H Petousis-Harris (388_CR53) 2017; 390
O Pérez (388_CR50) 2009; 18
EA Semchenko (388_CR64) 2016; 92
EA Semchenko (388_CR30) 2019; 69
AW Dretler (388_CR9) 2018; 14
DM Granoff (388_CR14) 2010; 50
C Fazio (388_CR40) 2021; 17
R Borrow (388_CR43) 2020; 81
A Biolchi (388_CR31) 2020; 38
SN Ladhani (388_CR48) 2020; 73
X Wang (388_CR24) 2011; 29
A Biolchi (388_CR46) 2021; 40
A Biolchi (388_CR39) 2021; 10
EN Natali (388_CR26) 2020; 34
R Hadad (388_CR3) 2012; 120
J Rowley (388_CR8) 2019; 97
H Marjuki (388_CR28) 2019; 10
R Rappuoli (388_CR22) 2018; 17
CMC Rodrigues (388_CR44) 2020; 59
J Longtin (388_CR58) 2017; 4
W Abara (388_CR60) 2020; 47
V Masignani (388_CR12) 2019; 10
DKS Law (388_CR33) 2015; 15
P De Wals (388_CR59) 2017; 64
M Plante (388_CR55) 2000; 182
J Finne (388_CR11) 1987; 138
L Hafner (388_CR63) 2008; 1
A Bianchi (388_CR35) 2015; 56
M Pizza (388_CR32) 2015; 23
H Tettelin (388_CR21) 2000; 287
J Holst (388_CR15) 2013; 9
R Rubin (388_CR45) 2021; 325
388_CR29
CR Tinsley (388_CR1) 1996; 93
W Abara (388_CR61) 2021; 48
HS Marshall (388_CR62) 2021; 17
M Unemo (388_CR4) 2019; 5
S Leo (388_CR37) 2020; 38
Y Liu (388_CR56) 2017; 10
A Perrin (388_CR2) 2002; 70
DM Vu (388_CR25) 2011; 29
E Perez-Trallero (388_CR34) 2014; 9
MM Giuliani (388_CR18) 2006; 103
M Pizza (388_CR20) 2000; 287
J Paynter (388_CR54) 2019; 7
KA McElligott (388_CR7) 2014; 104
I Leduc (388_CR57) 2020; 16
NE Rosenstein (388_CR5) 2001; 344
References_xml – volume: 16
  start-page: e1008602
  year: 2020
  ident: CR57
  article-title: The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1008602
  contributor:
    fullname: Leduc
– volume: 17
  start-page: 1
  year: 2021
  end-page: 7
  ident: CR40
  article-title: Cross-reactivity of 4CMenB vaccine-induced antibodies against meningococci belonging to non-B serogroups in Italy
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.1080/21645515.2020.1855951
  contributor:
    fullname: Fazio
– volume: 9
  start-page: e116024
  year: 2014
  ident: CR34
  article-title: Progressive decrease in the potential usefulness of meningococcal serogroup B vaccine (4CMenB, Bexsero(R)) in Gipuzkoa, Northern Spain
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0116024
  contributor:
    fullname: Marimon
– volume: 73
  start-page: e1661
  year: 2020
  end-page: e1668
  ident: CR48
  article-title: First real world evidence of meningococcal group B vaccine, 4CMenB, protection against meningococcal group W disease; prospective enhanced national surveillance, England
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciaa1244
  contributor:
    fullname: Ladhani
– volume: 29
  start-page: 4739
  year: 2011
  end-page: 4744
  ident: CR24
  article-title: Prevalence and genetic diversity of candidate vaccine antigens among invasive isolates in the United States
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.04.092
  contributor:
    fullname: Wang
– volume: 29
  start-page: 1968
  year: 2011
  end-page: 1973
  ident: CR25
  article-title: Cooperative serum bactericidal activity between human antibodies to meningococcal factor H binding protein and neisserial heparin binding antigen
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2010.12.075
  contributor:
    fullname: Granoff
– volume: 92
  start-page: 561
  year: 2016
  end-page: 562
  ident: CR64
  article-title: Intractable problems require novel solutions: it’s time to get serious about developing a gonorrhoea vaccine
  publication-title: Sex. Transm. Infect.
  doi: 10.1136/sextrans-2015-052378
  contributor:
    fullname: Seib
– volume: 344
  start-page: 1378
  year: 2001
  end-page: 1388
  ident: CR5
  article-title: Meningococcal disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM200105033441807
  contributor:
    fullname: Hughes
– ident: CR29
– volume: 324
  start-page: 2187
  year: 2020
  end-page: 2194
  ident: CR49
  article-title: Association of use of a meningococcus group B vaccine with group B invasive meningococcal disease among children in Portugal
  publication-title: JAMA
  doi: 10.1001/jama.2020.20449
  contributor:
    fullname: Rodrigues
– volume: 5
  start-page: 79
  year: 2019
  ident: CR4
  article-title: Gonorrhoea
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-019-0128-6
  contributor:
    fullname: Unemo
– volume: 47
  start-page: S46
  year: 2020
  ident: CR60
  article-title: Case-control study to evaluate the effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhea, New York city and Philadelphia, 2016–2018
  publication-title: J. Sex. Transm. Dis.
  contributor:
    fullname: Abara
– volume: 15
  start-page: 143
  year: 2015
  ident: CR33
  article-title: Characterization of invasive strains from Quebec, Canada, during a period of increased serogroup B disease, 2009-2013: phenotyping and genotyping with special emphasis on the non-carbohydrate protein vaccine targets
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-015-0469-6
  contributor:
    fullname: Law
– volume: 22
  start-page: 309
  year: 2016
  end-page: 311
  ident: CR41
  article-title: Effectiveness of meningococcal B vaccine against endemic hypervirulent W strain, England
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2202.150369
  contributor:
    fullname: Ladhani
– volume: 13
  start-page: 255
  year: 2017
  end-page: 265
  ident: CR17
  article-title: Meningococcal serogroup B vaccines: estimating breadth of coverage
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.1080/21645515.2017.1264750
  contributor:
    fullname: Donald
– volume: 81
  start-page: 862
  year: 2020
  end-page: 872
  ident: CR43
  article-title: Methods to evaluate serogroup B meningococcal vaccines: from predictions to real-world evidence
  publication-title: J. Infect.
  doi: 10.1016/j.jinf.2020.07.034
  contributor:
    fullname: Borrow
– volume: 75
  start-page: 95
  year: 2017
  end-page: 103
  ident: CR38
  article-title: Frequent capsule switching in ‘ultra-virulent’ meningococci - are we ready for a serogroup B ST-11 complex outbreak?
  publication-title: J. Infect.
  doi: 10.1016/j.jinf.2017.05.015
  contributor:
    fullname: Lucidarme
– volume: 31
  start-page: 1113
  year: 2013
  end-page: 1116
  ident: CR42
  article-title: Could the multicomponent meningococcal serogroup B vaccine (4CMenB) control capsular group X outbreaks in Africa?
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.12.022
  contributor:
    fullname: Hong
– volume: 97
  start-page: 548
  year: 2019
  end-page: 562
  ident: CR8
  article-title: Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016
  publication-title: Bull. World Health Organ.
  doi: 10.2471/BLT.18.228486
  contributor:
    fullname: Rowley
– ident: CR19
– volume: 69
  start-page: 1101
  year: 2019
  end-page: 1111
  ident: CR30
  article-title: The serogroup B meningococcal vaccine Bexsero elicits antibodies to
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciy1061
  contributor:
    fullname: Seib
– volume: 20
  start-page: 391
  year: 2014
  end-page: 395
  ident: CR6
  article-title: ; clones, carriage, and disease
  publication-title: Clin. Microbiol. Infect.
  doi: 10.1111/1469-0691.12647
  contributor:
    fullname: Read
– volume: 10
  start-page: e01668-01619
  year: 2019
  ident: CR28
  article-title: Genetic similarity of gonococcal homologs to meningococcal outer membrane proteins of serogroup B vaccine
  publication-title: mBio
  doi: 10.1128/mBio.01668-19
  contributor:
    fullname: Marjuki
– volume: 325
  start-page: 1241
  year: 2021
  end-page: 1243
  ident: CR45
  article-title: COVID-19 vaccines vs variants—determining how much immunity is enough
  publication-title: JAMA
  doi: 10.1001/jama.2021.3370
  contributor:
    fullname: Rubin
– volume: 14
  start-page: 1146
  year: 2018
  end-page: 1160
  ident: CR9
  article-title: Progress toward the global control of : 21st century vaccines, current guidelines, and challenges for future vaccine development
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.1080/21645515.2018.1451810
  contributor:
    fullname: Stephens
– volume: 138
  start-page: 4402
  year: 1987
  end-page: 4407
  ident: CR11
  article-title: An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.138.12.4402
  contributor:
    fullname: Finne
– volume: 18
  start-page: 53
  year: 2009
  end-page: 55
  ident: CR50
  article-title: Mucosal approaches in Neisseria vaccinology
  publication-title: Vaccimonitor
  contributor:
    fullname: Pérez
– volume: 103
  start-page: 10834
  year: 2006
  end-page: 10839
  ident: CR18
  article-title: A universal vaccine for serogroup B meningococcus
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0603940103
  contributor:
    fullname: Giuliani
– volume: 120
  start-page: 750
  year: 2012
  end-page: 760
  ident: CR3
  article-title: Novel meningococcal 4CMenB vaccine antigens – prevalence and polymorphisms of the encoding genes in
  publication-title: APMIS
  doi: 10.1111/j.1600-0463.2012.02903.x
  contributor:
    fullname: Hadad
– volume: 287
  start-page: 1816
  year: 2000
  end-page: 1820
  ident: CR20
  article-title: Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing
  publication-title: Science
  doi: 10.1126/science.287.5459.1816
  contributor:
    fullname: Pizza
– volume: 182
  start-page: 848
  year: 2000
  end-page: 855
  ident: CR55
  article-title: Intranasal immunization with gonococcal outer membrane preparations reduces the duration of vaginal colonization of mice by
  publication-title: J. Infect. Dis.
  doi: 10.1086/315801
  contributor:
    fullname: Plante
– volume: 40
  start-page: 375
  year: 2021
  end-page: 381
  ident: CR52
  article-title: VA-MENGOC-BC vaccination induces serum and mucosal anti immune responses and reduces the incidence of gonorrhea
  publication-title: Pediatr. Infect. Dis. J.
  doi: 10.1097/INF.0000000000003047
  contributor:
    fullname: Reyes Díaz
– volume: 9
  start-page: 1241
  year: 2013
  end-page: 1253
  ident: CR15
  article-title: Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): lessons from past programs and implications for the future
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.4161/hv.24129
  contributor:
    fullname: Holst
– volume: 22
  start-page: 1137
  year: 2016
  end-page: 1139
  ident: CR51
  article-title: Ecologic study of meningococcal B vaccine and infection, Norway
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2206.151093
  contributor:
    fullname: Storsaeter
– volume: 17
  start-page: 1450
  year: 2021
  end-page: 1454
  ident: CR62
  article-title: Evaluating the effectiveness of the 4CMenB vaccine against invasive meningococcal disease and gonorrhoea in an infant, child and adolescent program: protocol
  publication-title: Hum. Vaccin. Immunother
  doi: 10.1080/21645515.2020.1827614
  contributor:
    fullname: Marshall
– volume: 59
  start-page: e02161
  year: 2020
  end-page: -20
  ident: CR44
  article-title: Meningococcal Deduced Vaccine Antigen Reactivity (MenDeVAR) Index: a rapid and accessible tool that exploits genomic data in public health and clinical microbiology applications
  publication-title: J. Clin. Microbiol
  doi: 10.1128/JCM.02161-20
  contributor:
    fullname: Rodrigues
– volume: 17
  start-page: 1111
  year: 2018
  end-page: 1121
  ident: CR22
  article-title: Meningococcal B vaccine (4CMenB): the journey from research to real world experience
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2018.1547637
  contributor:
    fullname: Vadivelu
– volume: 390
  start-page: 1603
  year: 2017
  end-page: 1610
  ident: CR53
  article-title: Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31449-6
  contributor:
    fullname: Petousis-Harris
– volume: 24
  start-page: 673
  year: 2018
  end-page: 682
  ident: CR36
  article-title: Genomic surveillance of 4CMenB vaccine antigenic variants among disease-causing isolates, United Kingdom, 2010–2016
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2404.171480
  contributor:
    fullname: Rodrigues
– volume: 10
  start-page: 1
  year: 2019
  end-page: 14
  ident: CR12
  article-title: The development of a vaccine against meningococcus B using reverse vaccinology
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00751
  contributor:
    fullname: Moxon
– volume: 70
  start-page: 7063
  year: 2002
  end-page: 7072
  ident: CR2
  article-title: Comparative genomics identifies the genetic islands that distinguish , the agent of cerebrospinal meningitis, from other Neisseria species
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.70.12.7063-7072.2002
  contributor:
    fullname: Perrin
– volume: 104
  start-page: e101
  year: 2014
  end-page: e105
  ident: CR7
  article-title: Mortality from sexually transmitted diseases in reproductive-aged women: United States, 1999–2010
  publication-title: Am. J. Public Health
  doi: 10.2105/AJPH.2014.302044
  contributor:
    fullname: McElligott
– volume: 48
  start-page: e34
  year: 2021
  ident: CR61
  article-title: 2020 STD Prevention Conference September 14–24, 2020: erratum
  publication-title: J. Sex. Transm. Dis.
  doi: 10.1097/OLQ.0000000000001346
  contributor:
    fullname: Abara
– volume: 1
  start-page: 116
  year: 2008
  end-page: 130
  ident: CR63
  article-title: infection: host immune responses and potential vaccines
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2007.19
  contributor:
    fullname: Timms
– volume: 93
  start-page: 11109
  year: 1996
  end-page: 11114
  ident: CR1
  article-title: Analysis of the genetic differences between and : two closely related bacteria expressing two different pathogenicities
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.20.11109
  contributor:
    fullname: Nassif
– volume: 83
  start-page: 17
  year: 2021
  end-page: 26
  ident: CR47
  article-title: Recent advances in meningococcal B disease prevention: real-world evidence from 4CMenB vaccination
  publication-title: J. Infect.
  doi: 10.1016/j.jinf.2021.04.031
  contributor:
    fullname: Martinón-Torres
– volume: 38
  start-page: 5324
  year: 2020
  end-page: 5331
  ident: CR37
  article-title: Strain coverage of Bexsero vaccine assessed by whole-genome sequencing over a cohort of invasive meningococci of serogroups B and W isolated in Switzerland
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2020.05.071
  contributor:
    fullname: Leo
– volume: 23
  start-page: 68
  year: 2015
  end-page: 72
  ident: CR32
  article-title: : pathogenesis and immunity
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2014.11.006
  contributor:
    fullname: Rappuoli
– volume: 10
  start-page: 1594
  year: 2017
  end-page: 1608
  ident: CR56
  article-title: Experimental vaccine induces Th1-driven immune responses and resistance to infection in a murine model
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2017.11
  contributor:
    fullname: Liu
– volume: 4
  start-page: S734
  year: 2017
  end-page: S735
  ident: CR58
  article-title: Possible impact of wide-scale vaccination against serogroup B on gonorrhea incidence rates in one region of Quebec, Canada
  publication-title: Open Forum Infect. Dis.
  doi: 10.1093/ofid/ofx180.002
  contributor:
    fullname: Longtin
– volume: 30
  start-page: B87
  issue: Suppl 2
  year: 2012
  end-page: B97
  ident: CR16
  article-title: The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.01.033
  contributor:
    fullname: Rappuoli
– volume: 40
  start-page: e66
  year: 2021
  end-page: e71
  ident: CR46
  article-title: Four-component meningococcal serogroup B vaccine induces antibodies with bactericidal activity against diverse outbreak strains in adolescents
  publication-title: Pediatr. Infect. Dis. J.
  doi: 10.1097/INF.0000000000002957
  contributor:
    fullname: Biolchi
– volume: 34
  start-page: 10329
  year: 2020
  end-page: 10341
  ident: CR26
  article-title: Synergic complement-mediated bactericidal activity of monoclonal antibodies with distinct specificity
  publication-title: FASEB J.
  doi: 10.1096/fj.201902795R
  contributor:
    fullname: Natali
– volume: 10
  start-page: 307
  year: 2021
  end-page: 316
  ident: CR39
  article-title: 4CMenB immunization induces serum bactericidal antibodies against non-serogroup B meningococcal strains in adolescents
  publication-title: Infect. Dis. Ther.
  doi: 10.1007/s40121-020-00370-x
  contributor:
    fullname: Biolchi
– volume: 8
  year: 2018
  ident: CR27
  article-title: Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-22057-7
  contributor:
    fullname: Giuliani
– volume: 50
  start-page: S54
  issue: Suppl 2
  year: 2010
  end-page: 65
  ident: CR14
  article-title: Review of meningococcal group B vaccines
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/648966
  contributor:
    fullname: Granoff
– volume: 16
  start-page: 313
  year: 2017
  end-page: 328
  ident: CR10
  article-title: The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2017.1258308
  contributor:
    fullname: Borrow
– volume: 2
  start-page: 355
  year: 1983
  end-page: 357
  ident: CR13
  article-title: Antigenic similarities between brain components and bacteria causing meningitis. Implications for vaccine development and pathogenesis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(83)90340-9
  contributor:
    fullname: Mäkelä
– volume: 38
  start-page: 7542
  year: 2020
  end-page: 7550
  ident: CR31
  article-title: Multicomponent meningococcal serogroup B vaccination elicits cross-reactive immunity in infants against genetically diverse serogroup C, W and Y invasive disease isolates
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2020.09.050
  contributor:
    fullname: Biolchi
– volume: 56
  start-page: E140
  year: 2015
  end-page: E143
  ident: CR35
  article-title: Meningococcal B vaccine and the vision of a meningitis free world
  publication-title: J. Prev. Med. Hyg.
  contributor:
    fullname: Prugnola
– volume: 7
  start-page: 1
  year: 2019
  end-page: 11
  ident: CR54
  article-title: Effectiveness of a group B outer membrane vesicle meningococcal vaccine in preventing hospitalization from gonorrhea in New Zealand: a retrospective cohort study
  publication-title: Vaccines
  doi: 10.3390/vaccines7010005
  contributor:
    fullname: Paynter
– volume: 287
  start-page: 1809
  year: 2000
  end-page: 1815
  ident: CR21
  article-title: Complete genome sequence of serogroup B strain MC58
  publication-title: Science
  doi: 10.1126/science.287.5459.1809
  contributor:
    fullname: Tettelin
– volume: 113
  start-page: 2714
  year: 2016
  end-page: 2719
  ident: CR23
  article-title: Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1521142113
  contributor:
    fullname: Biagini
– volume: 64
  start-page: 1263
  year: 2017
  end-page: 1267
  ident: CR59
  article-title: Impact of an immunization campaign to control an increased incidence of serogroup B meningococcal disease in one region of Quebec, Canada
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix154
  contributor:
    fullname: De Wals
– volume: 287
  start-page: 1816
  year: 2000
  ident: 388_CR20
  publication-title: Science
  doi: 10.1126/science.287.5459.1816
  contributor:
    fullname: M Pizza
– volume: 17
  start-page: 1111
  year: 2018
  ident: 388_CR22
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2018.1547637
  contributor:
    fullname: R Rappuoli
– volume: 40
  start-page: e66
  year: 2021
  ident: 388_CR46
  publication-title: Pediatr. Infect. Dis. J.
  doi: 10.1097/INF.0000000000002957
  contributor:
    fullname: A Biolchi
– volume: 18
  start-page: 53
  year: 2009
  ident: 388_CR50
  publication-title: Vaccimonitor
  contributor:
    fullname: O Pérez
– volume: 73
  start-page: e1661
  year: 2020
  ident: 388_CR48
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciaa1244
  contributor:
    fullname: SN Ladhani
– volume: 56
  start-page: E140
  year: 2015
  ident: 388_CR35
  publication-title: J. Prev. Med. Hyg.
  contributor:
    fullname: A Bianchi
– volume: 14
  start-page: 1146
  year: 2018
  ident: 388_CR9
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.1080/21645515.2018.1451810
  contributor:
    fullname: AW Dretler
– volume: 64
  start-page: 1263
  year: 2017
  ident: 388_CR59
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix154
  contributor:
    fullname: P De Wals
– volume: 31
  start-page: 1113
  year: 2013
  ident: 388_CR42
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.12.022
  contributor:
    fullname: E Hong
– volume: 38
  start-page: 5324
  year: 2020
  ident: 388_CR37
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2020.05.071
  contributor:
    fullname: S Leo
– volume: 7
  start-page: 1
  year: 2019
  ident: 388_CR54
  publication-title: Vaccines
  doi: 10.3390/vaccines7010005
  contributor:
    fullname: J Paynter
– volume: 30
  start-page: B87
  issue: Suppl 2
  year: 2012
  ident: 388_CR16
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2012.01.033
  contributor:
    fullname: D Serruto
– volume: 9
  start-page: 1241
  year: 2013
  ident: 388_CR15
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.4161/hv.24129
  contributor:
    fullname: J Holst
– volume: 69
  start-page: 1101
  year: 2019
  ident: 388_CR30
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/ciy1061
  contributor:
    fullname: EA Semchenko
– volume: 50
  start-page: S54
  issue: Suppl 2
  year: 2010
  ident: 388_CR14
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/648966
  contributor:
    fullname: DM Granoff
– volume: 104
  start-page: e101
  year: 2014
  ident: 388_CR7
  publication-title: Am. J. Public Health
  doi: 10.2105/AJPH.2014.302044
  contributor:
    fullname: KA McElligott
– volume: 2
  start-page: 355
  year: 1983
  ident: 388_CR13
  publication-title: Lancet
  doi: 10.1016/S0140-6736(83)90340-9
  contributor:
    fullname: J Finne
– ident: 388_CR19
  doi: 10.1093/femspd/ftx033
– volume: 4
  start-page: S734
  year: 2017
  ident: 388_CR58
  publication-title: Open Forum Infect. Dis.
  doi: 10.1093/ofid/ofx180.002
  contributor:
    fullname: J Longtin
– volume: 16
  start-page: e1008602
  year: 2020
  ident: 388_CR57
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1008602
  contributor:
    fullname: I Leduc
– volume: 20
  start-page: 391
  year: 2014
  ident: 388_CR6
  publication-title: Clin. Microbiol. Infect.
  doi: 10.1111/1469-0691.12647
  contributor:
    fullname: RC Read
– volume: 24
  start-page: 673
  year: 2018
  ident: 388_CR36
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2404.171480
  contributor:
    fullname: CMC Rodrigues
– volume: 17
  start-page: 1
  year: 2021
  ident: 388_CR40
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.1080/21645515.2020.1855951
  contributor:
    fullname: C Fazio
– volume: 8
  year: 2018
  ident: 388_CR27
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-22057-7
  contributor:
    fullname: M Giuliani
– volume: 120
  start-page: 750
  year: 2012
  ident: 388_CR3
  publication-title: APMIS
  doi: 10.1111/j.1600-0463.2012.02903.x
  contributor:
    fullname: R Hadad
– volume: 38
  start-page: 7542
  year: 2020
  ident: 388_CR31
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2020.09.050
  contributor:
    fullname: A Biolchi
– volume: 324
  start-page: 2187
  year: 2020
  ident: 388_CR49
  publication-title: JAMA
  doi: 10.1001/jama.2020.20449
  contributor:
    fullname: FMP Rodrigues
– volume: 182
  start-page: 848
  year: 2000
  ident: 388_CR55
  publication-title: J. Infect. Dis.
  doi: 10.1086/315801
  contributor:
    fullname: M Plante
– volume: 13
  start-page: 255
  year: 2017
  ident: 388_CR17
  publication-title: Hum. Vaccin. Immunother.
  doi: 10.1080/21645515.2017.1264750
  contributor:
    fullname: RGK Donald
– volume: 97
  start-page: 548
  year: 2019
  ident: 388_CR8
  publication-title: Bull. World Health Organ.
  doi: 10.2471/BLT.18.228486
  contributor:
    fullname: J Rowley
– volume: 16
  start-page: 313
  year: 2017
  ident: 388_CR10
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2017.1258308
  contributor:
    fullname: R Borrow
– volume: 75
  start-page: 95
  year: 2017
  ident: 388_CR38
  publication-title: J. Infect.
  doi: 10.1016/j.jinf.2017.05.015
  contributor:
    fullname: J Lucidarme
– volume: 70
  start-page: 7063
  year: 2002
  ident: 388_CR2
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.70.12.7063-7072.2002
  contributor:
    fullname: A Perrin
– volume: 113
  start-page: 2714
  year: 2016
  ident: 388_CR23
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1521142113
  contributor:
    fullname: M Biagini
– volume: 22
  start-page: 309
  year: 2016
  ident: 388_CR41
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2202.150369
  contributor:
    fullname: SN Ladhani
– volume: 325
  start-page: 1241
  year: 2021
  ident: 388_CR45
  publication-title: JAMA
  doi: 10.1001/jama.2021.3370
  contributor:
    fullname: R Rubin
– volume: 138
  start-page: 4402
  year: 1987
  ident: 388_CR11
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.138.12.4402
  contributor:
    fullname: J Finne
– volume: 23
  start-page: 68
  year: 2015
  ident: 388_CR32
  publication-title: Curr. Opin. Microbiol.
  doi: 10.1016/j.mib.2014.11.006
  contributor:
    fullname: M Pizza
– volume: 47
  start-page: S46
  year: 2020
  ident: 388_CR60
  publication-title: J. Sex. Transm. Dis.
  contributor:
    fullname: W Abara
– volume: 9
  start-page: e116024
  year: 2014
  ident: 388_CR34
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0116024
  contributor:
    fullname: E Perez-Trallero
– volume: 10
  start-page: e01668-01619
  year: 2019
  ident: 388_CR28
  publication-title: mBio
  doi: 10.1128/mBio.01668-19
  contributor:
    fullname: H Marjuki
– ident: 388_CR29
  doi: 10.3390/vaccines8020219
– volume: 40
  start-page: 375
  year: 2021
  ident: 388_CR52
  publication-title: Pediatr. Infect. Dis. J.
  doi: 10.1097/INF.0000000000003047
  contributor:
    fullname: LM Reyes Díaz
– volume: 48
  start-page: e34
  year: 2021
  ident: 388_CR61
  publication-title: J. Sex. Transm. Dis.
  doi: 10.1097/OLQ.0000000000001346
  contributor:
    fullname: W Abara
– volume: 10
  start-page: 1
  year: 2019
  ident: 388_CR12
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00751
  contributor:
    fullname: V Masignani
– volume: 29
  start-page: 4739
  year: 2011
  ident: 388_CR24
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2011.04.092
  contributor:
    fullname: X Wang
– volume: 22
  start-page: 1137
  year: 2016
  ident: 388_CR51
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid2206.151093
  contributor:
    fullname: J Whelan
– volume: 17
  start-page: 1450
  year: 2021
  ident: 388_CR62
  publication-title: Hum. Vaccin. Immunother
  doi: 10.1080/21645515.2020.1827614
  contributor:
    fullname: HS Marshall
– volume: 10
  start-page: 1594
  year: 2017
  ident: 388_CR56
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2017.11
  contributor:
    fullname: Y Liu
– volume: 83
  start-page: 17
  year: 2021
  ident: 388_CR47
  publication-title: J. Infect.
  doi: 10.1016/j.jinf.2021.04.031
  contributor:
    fullname: F Martinón-Torres
– volume: 344
  start-page: 1378
  year: 2001
  ident: 388_CR5
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM200105033441807
  contributor:
    fullname: NE Rosenstein
– volume: 93
  start-page: 11109
  year: 1996
  ident: 388_CR1
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.20.11109
  contributor:
    fullname: CR Tinsley
– volume: 287
  start-page: 1809
  year: 2000
  ident: 388_CR21
  publication-title: Science
  doi: 10.1126/science.287.5459.1809
  contributor:
    fullname: H Tettelin
– volume: 59
  start-page: e02161
  year: 2020
  ident: 388_CR44
  publication-title: J. Clin. Microbiol
  doi: 10.1128/JCM.02161-20
  contributor:
    fullname: CMC Rodrigues
– volume: 29
  start-page: 1968
  year: 2011
  ident: 388_CR25
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2010.12.075
  contributor:
    fullname: DM Vu
– volume: 5
  start-page: 79
  year: 2019
  ident: 388_CR4
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-019-0128-6
  contributor:
    fullname: M Unemo
– volume: 92
  start-page: 561
  year: 2016
  ident: 388_CR64
  publication-title: Sex. Transm. Infect.
  doi: 10.1136/sextrans-2015-052378
  contributor:
    fullname: EA Semchenko
– volume: 1
  start-page: 116
  year: 2008
  ident: 388_CR63
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2007.19
  contributor:
    fullname: L Hafner
– volume: 34
  start-page: 10329
  year: 2020
  ident: 388_CR26
  publication-title: FASEB J.
  doi: 10.1096/fj.201902795R
  contributor:
    fullname: EN Natali
– volume: 103
  start-page: 10834
  year: 2006
  ident: 388_CR18
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0603940103
  contributor:
    fullname: MM Giuliani
– volume: 390
  start-page: 1603
  year: 2017
  ident: 388_CR53
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31449-6
  contributor:
    fullname: H Petousis-Harris
– volume: 10
  start-page: 307
  year: 2021
  ident: 388_CR39
  publication-title: Infect. Dis. Ther.
  doi: 10.1007/s40121-020-00370-x
  contributor:
    fullname: A Biolchi
– volume: 81
  start-page: 862
  year: 2020
  ident: 388_CR43
  publication-title: J. Infect.
  doi: 10.1016/j.jinf.2020.07.034
  contributor:
    fullname: R Borrow
– volume: 15
  start-page: 143
  year: 2015
  ident: 388_CR33
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-015-0469-6
  contributor:
    fullname: DKS Law
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Snippet Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence...
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80-90% genome sequence...
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80–90% genome sequence...
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SubjectTerms 631/250/255/1318
631/250/590/2294
Antigens
Bacterial infections
Biomedical and Life Sciences
Biomedicine
Genotype & phenotype
Gonorrhea
Immunization
Infectious Diseases
Medical Microbiology
Meningitis
Public Health
Review
Review Article
Sexually transmitted diseases
STD
Vaccine
Vaccines
Virology
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Title Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect
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