The trans-omics landscape of COVID-19

• Published in: Nature communications Vol. 12; no. 1; pp. 4543 - 16
• Main Authors: Wu, Peng, Chen, Dongsheng, Ding, Wencheng, Wu, Ping, Hou, Hongyan, Bai, Yong, Zhou, Yuwen, Li, Kezhen, Xiang, Shunian, Liu, Panhong, Ju, Jia, Guo, Ensong, Liu, Jia, Yang, Bin, Fan, Junpeng, He, Liang, Sun, Ziyong, Feng, Ling, Wang, Jian, Wu, Tangchun, Wang, Hao, Cheng, Jin, Xing, Hui, Meng, Yifan, Li, Yongsheng, Zhang, Yuanliang, Luo, Hongbo, Xie, Gang, Lan, Xianmei, Tao, Ye, Li, Jiafeng, Yuan, Hao, Huang, Kang, Sun, Wan, Qian, Xiaobo, Li, Zhichao, Huang, Mingxi, Ding, Peiwen, Wang, Haoyu, Qiu, Jiaying, Wang, Feiyue, Wang, Shiyou, Zhu, Jiacheng, Ding, Xiangning, Chai, Chaochao, Liang, Langchao, Wang, Xiaoling, Luo, Lihua, Sun, Yuzhe, Yang, Ying, Zhuang, Zhenkun, Li, Tao, Tian, Lei, Zhang, Shaoqiao, Zhu, Linnan, Chang, Ashley, Chen, Lei, Wu, Yiquan, Ma, Xiaoyan, Chen, Fang, Ren, Yan, Xu, Xun, Liu, Siqi, Yang, Huanming, Wang, Lin, Sun, Chaoyang, Ma, Ding, Jin, Xin, Chen, Gang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.07.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 38/23; 38/43; 38/91; 631/250/2499; 631/250/2502; 631/250/255/2514; 631/553/1833; Asymptomatic; Blood; Cell activation; Coronaviruses; COVID-19; COVID-19 - genetics; COVID-19 - metabolism; Critical Illness; Depletion; Genomic analysis; Genomics - methods; Global health; Health risks; Heterogeneity; Humanities and Social Sciences; Humans; Leukocytes (neutrophilic); Lipidomics - methods; Lymphocytes; Lymphocytes T; Metabolites; Metabolomics; Metabolomics - methods; multidisciplinary; Neutrophils; Neutrophils - metabolism; Pathophysiology; Peripheral blood; Proteomics; Public health; Science; Science (multidisciplinary); Signs and symptoms; Transcriptome - genetics; Tryptophan; Viral diseases

The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...