Aryl hydrocarbon receptor and Krüppel like factor 10 mediate a transcriptional axis modulating immune homeostasis in mosquitoes

• Published in: Scientific reports Vol. 12; no. 1; p. 6005
• Main Authors: Kulkarni, Aditi, Pandey, Ashmita, Trainor, Patrick, Carlisle, Samantha, Yu, Wanqin, Kukutla, Phanidhar, Xu, Jiannong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/326; 631/337; Agonists; Animals; Antagonists; Aquatic insects; Circadian rhythms; Culicidae - metabolism; Early Growth Response Transcription Factors - genetics; Homeostasis; Humanities and Social Sciences; Hydrocarbons; Immune response; Immunomodulation; Immunoregulation; Kruppel-Like Transcription Factors - metabolism; Mosquitoes; multidisciplinary; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - metabolism; Science; Science (multidisciplinary); Transcription factors; Transcriptomes; Zinc finger proteins

Immune responses require delicate controls to maintain homeostasis while executing effective defense. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. The Krüppel-like factor 10 (KLF10) is a C2H2 zinc-finger containing transcription factor. The functions of mosquito AhR an...