Conformational dynamics of the Beta and Kappa SARS-CoV-2 spike proteins and their complexes with ACE2 receptor revealed by cryo-EM

• Published in: Nature communications Vol. 12; no. 1; pp. 7345 - 13
• Main Authors: Wang, Yifan, Xu, Cong, Wang, Yanxing, Hong, Qin, Zhang, Chao, Li, Zuyang, Xu, Shiqi, Zuo, Qinyu, Liu, Caixuan, Huang, Zhong, Cong, Yao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 42; 631/326/596/4130; 631/45/535/1258/1259; 82/1; 82/80; 82/83; ACE2; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - chemistry; Antibodies; Antibodies, Neutralizing - immunology; Binding; Binding Sites; Biochemical analysis; COVID-19; Cryoelectron Microscopy; Humanities and Social Sciences; Humans; Kinetics; Molecular Conformation; multidisciplinary; Mutation; Neutralizing; Pandemics; Pathogenicity; Pathogens; Protein Binding; Protein structure; Proteins; Receptors; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Trimers; Viral diseases

The emergence of SARS-CoV-2 Kappa and Beta variants with enhanced transmissibility and resistance to neutralizing antibodies has created new challenges for the control of the ongoing COVID-19 pandemic. Understanding the structural nature of Kappa and Beta spike (S) proteins and their association wit...