Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
Transforming growth factor β (TGFβ) is important in maintaining self-tolerance and inhibits T cell reactivity. We show that CD8 + T cells that lack the tyrosine phosphatase Ptpn22 , a major predisposing gene for autoimmune disease, are resistant to the suppressive effects of TGFβ. Resistance to TGFβ...
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Published in | Nature communications Vol. 8; no. 1; pp. 1343 - 10 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
07.11.2017
Nature Publishing Group Nature Portfolio |
Subjects | |
Online Access | Get full text |
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