PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its low expression in adult tissues and its overexpressi...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 11; no. 1; p. 3520
Main Authors Mzoughi, Slim, Fong, Jia Yi, Papadopoli, David, Koh, Cheryl M., Hulea, Laura, Pigini, Paolo, Di Tullio, Federico, Andreacchio, Giuseppe, Hoppe, Michal Marek, Wollmann, Heike, Low, Diana, Caldez, Matias J., Peng, Yanfen, Torre, Denis, Zhao, Julia N., Uchenunu, Oro, Varano, Gabriele, Motofeanu, Corina-Mihaela, Lakshmanan, Manikandan, Teo, Shun Xie, Wun, Cheng Mun, Perini, Giovanni, Tan, Soo Yong, Ong, Chee Bing, Al-Haddawi, Muthafar, Rajarethinam, Ravisankar, Hue, Susan Swee-Shan, Lim, Soon Thye, Ong, Choon Kiat, Huang, Dachuan, Ng, Siok-Bian, Bernstein, Emily, Hasson, Dan, Wee, Keng Boon, Kaldis, Philipp, Jeyasekharan, Anand, Dominguez-sola, David, Topisirovic, Ivan, Guccione, Ernesto
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 14.07.2020
Nature Publishing Group
Nature Portfolio
Subjects
1-Phosphatidylinositol 3-kinase
38
38/15
38/91
631/337/2019
631/67/1990/291/1621/1915
64/60
96/106
96/95
AKT protein
Animals
Apoptosis - genetics
Apoptosis - physiology
B-cell lymphoma
Blotting, Western
Cancer
Cell death
Cell Survival - genetics
Cell Survival - physiology
Chromatin Immunoprecipitation
Computational Biology
Depletion
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Female
Flow Cytometry
Gene Expression Regulation - genetics
Gene Expression Regulation - physiology
Glycolysis
Homeostasis
Homology
Humanities and Social Sciences
Humans
Lymphocytes B
Lymphoma
Lymphoma - genetics
Lymphoma - metabolism
Metabolism
Mice
Mice, SCID
multidisciplinary
Oncology
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Random Allocation
Regulators
Science
Science (multidisciplinary)
Stem cells
TOR protein
Transcription
Transcription Factors - genetics
Transcription Factors - metabolism
Transcriptome - genetics
Online AccessGet full text

Cover

Abstract PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its low expression in adult tissues and its overexpression in B-cell lymphomas. Despite its well characterized role in stem cell biology and during early development, the role of PRDM15 in cancer remains obscure. Herein, we demonstrate that while PRDM15 is largely dispensable for mouse adult somatic cell homeostasis in vivo, it plays a critical role in B-cell lymphomagenesis. Mechanistically, PRDM15 regulates a transcriptional program that sustains the activity of the PI3K/AKT/mTOR pathway and glycolysis in B-cell lymphomas. Abrogation of PRDM15 induces a metabolic crisis and selective death of lymphoma cells. Collectively, our data demonstrate that PRDM15 fuels the metabolic requirement of B-cell lymphomas and validate it as an attractive and previously unrecognized target in oncology. The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.
AbstractList PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its low expression in adult tissues and its overexpression in B-cell lymphomas. Despite its well characterized role in stem cell biology and during early development, the role of PRDM15 in cancer remains obscure. Herein, we demonstrate that while PRDM15 is largely dispensable for mouse adult somatic cell homeostasis in vivo, it plays a critical role in B-cell lymphomagenesis. Mechanistically, PRDM15 regulates a transcriptional program that sustains the activity of the PI3K/AKT/mTOR pathway and glycolysis in B-cell lymphomas. Abrogation of PRDM15 induces a metabolic crisis and selective death of lymphoma cells. Collectively, our data demonstrate that PRDM15 fuels the metabolic requirement of B-cell lymphomas and validate it as an attractive and previously unrecognized target in oncology. The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.
Abstract PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its low expression in adult tissues and its overexpression in B-cell lymphomas. Despite its well characterized role in stem cell biology and during early development, the role of PRDM15 in cancer remains obscure. Herein, we demonstrate that while PRDM15 is largely dispensable for mouse adult somatic cell homeostasis in vivo, it plays a critical role in B-cell lymphomagenesis. Mechanistically, PRDM15 regulates a transcriptional program that sustains the activity of the PI3K/AKT/mTOR pathway and glycolysis in B-cell lymphomas. Abrogation of PRDM15 induces a metabolic crisis and selective death of lymphoma cells. Collectively, our data demonstrate that PRDM15 fuels the metabolic requirement of B-cell lymphomas and validate it as an attractive and previously unrecognized target in oncology.
PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its low expression in adult tissues and its overexpression in B-cell lymphomas. Despite its well characterized role in stem cell biology and during early development, the role of PRDM15 in cancer remains obscure. Herein, we demonstrate that while PRDM15 is largely dispensable for mouse adult somatic cell homeostasis in vivo, it plays a critical role in B-cell lymphomagenesis. Mechanistically, PRDM15 regulates a transcriptional program that sustains the activity of the PI3K/AKT/mTOR pathway and glycolysis in B-cell lymphomas. Abrogation of PRDM15 induces a metabolic crisis and selective death of lymphoma cells. Collectively, our data demonstrate that PRDM15 fuels the metabolic requirement of B-cell lymphomas and validate it as an attractive and previously unrecognized target in oncology.The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.
PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its low expression in adult tissues and its overexpression in B-cell lymphomas. Despite its well characterized role in stem cell biology and during early development, the role of PRDM15 in cancer remains obscure. Herein, we demonstrate that while PRDM15 is largely dispensable for mouse adult somatic cell homeostasis in vivo, it plays a critical role in B-cell lymphomagenesis. Mechanistically, PRDM15 regulates a transcriptional program that sustains the activity of the PI3K/AKT/mTOR pathway and glycolysis in B-cell lymphomas. Abrogation of PRDM15 induces a metabolic crisis and selective death of lymphoma cells. Collectively, our data demonstrate that PRDM15 fuels the metabolic requirement of B-cell lymphomas and validate it as an attractive and previously unrecognized target in oncology.
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.
ArticleNumber 3520
Author Andreacchio, Giuseppe
Uchenunu, Oro
Fong, Jia Yi
Di Tullio, Federico
Bernstein, Emily
Wee, Keng Boon
Varano, Gabriele
Ong, Chee Bing
Kaldis, Philipp
Mzoughi, Slim
Lim, Soon Thye
Jeyasekharan, Anand
Tan, Soo Yong
Pigini, Paolo
Huang, Dachuan
Wollmann, Heike
Dominguez-sola, David
Perini, Giovanni
Hoppe, Michal Marek
Low, Diana
Papadopoli, David
Wun, Cheng Mun
Koh, Cheryl M.
Torre, Denis
Hasson, Dan
Teo, Shun Xie
Guccione, Ernesto
Motofeanu, Corina-Mihaela
Peng, Yanfen
Topisirovic, Ivan
Hulea, Laura
Ng, Siok-Bian
Ong, Choon Kiat
Hue, Susan Swee-Shan
Rajarethinam, Ravisankar
Al-Haddawi, Muthafar
Caldez, Matias J.
Lakshmanan, Manikandan
Zhao, Julia N.
Author_xml – sequence: 1
  givenname: Slim
  surname: Mzoughi
  fullname: Mzoughi, Slim
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
– sequence: 2
  givenname: Jia Yi
  surname: Fong
  fullname: Fong, Jia Yi
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore
– sequence: 3
  givenname: David
  surname: Papadopoli
  fullname: Papadopoli, David
  organization: Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University
– sequence: 4
  givenname: Cheryl M.
  surname: Koh
  fullname: Koh, Cheryl M.
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 5
  givenname: Laura
  orcidid: 0000-0001-7585-7760
  surname: Hulea
  fullname: Hulea, Laura
  organization: Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University, Maisonneuve-Rosemont Hospital Research Centre, Département de Médecine, Université de Montréal
– sequence: 6
  givenname: Paolo
  surname: Pigini
  fullname: Pigini, Paolo
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Department of Pharmacy and Biotechnology, University of Bologna
– sequence: 7
  givenname: Federico
  orcidid: 0000-0001-9756-976X
  surname: Di Tullio
  fullname: Di Tullio, Federico
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 8
  givenname: Giuseppe
  surname: Andreacchio
  fullname: Andreacchio, Giuseppe
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Department of Pharmacy and Biotechnology, University of Bologna
– sequence: 9
  givenname: Michal Marek
  orcidid: 0000-0002-0364-6080
  surname: Hoppe
  fullname: Hoppe, Michal Marek
  organization: Cancer Science Institute (CSI), National University of Singapore
– sequence: 10
  givenname: Heike
  surname: Wollmann
  fullname: Wollmann, Heike
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 11
  givenname: Diana
  surname: Low
  fullname: Low, Diana
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 12
  givenname: Matias J.
  surname: Caldez
  fullname: Caldez, Matias J.
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Immunology Frontiers Research Center, Osaka University
– sequence: 13
  givenname: Yanfen
  surname: Peng
  fullname: Peng, Yanfen
  organization: Cancer Science Institute (CSI), National University of Singapore
– sequence: 14
  givenname: Denis
  surname: Torre
  fullname: Torre, Denis
  organization: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
– sequence: 15
  givenname: Julia N.
  surname: Zhao
  fullname: Zhao, Julia N.
  organization: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
– sequence: 16
  givenname: Oro
  surname: Uchenunu
  fullname: Uchenunu, Oro
  organization: Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University
– sequence: 17
  givenname: Gabriele
  surname: Varano
  fullname: Varano, Gabriele
  organization: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Immunology Institute and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
– sequence: 18
  givenname: Corina-Mihaela
  surname: Motofeanu
  fullname: Motofeanu, Corina-Mihaela
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 19
  givenname: Manikandan
  surname: Lakshmanan
  fullname: Lakshmanan, Manikandan
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 20
  givenname: Shun Xie
  surname: Teo
  fullname: Teo, Shun Xie
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 21
  givenname: Cheng Mun
  surname: Wun
  fullname: Wun, Cheng Mun
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 22
  givenname: Giovanni
  surname: Perini
  fullname: Perini, Giovanni
  organization: Department of Pharmacy and Biotechnology, University of Bologna
– sequence: 23
  givenname: Soo Yong
  surname: Tan
  fullname: Tan, Soo Yong
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Advanced Molecular Pathology Laboratory, IMCB, Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore
– sequence: 24
  givenname: Chee Bing
  orcidid: 0000-0002-0521-1646
  surname: Ong
  fullname: Ong, Chee Bing
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Advanced Molecular Pathology Laboratory, IMCB
– sequence: 25
  givenname: Muthafar
  surname: Al-Haddawi
  fullname: Al-Haddawi, Muthafar
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Advanced Molecular Pathology Laboratory, IMCB
– sequence: 26
  givenname: Ravisankar
  surname: Rajarethinam
  fullname: Rajarethinam, Ravisankar
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Advanced Molecular Pathology Laboratory, IMCB
– sequence: 27
  givenname: Susan Swee-Shan
  surname: Hue
  fullname: Hue, Susan Swee-Shan
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital (NUH)
– sequence: 28
  givenname: Soon Thye
  surname: Lim
  fullname: Lim, Soon Thye
  organization: Division of Medical Oncology, National Cancer Centre Singapore, Duke-NUS Graduate Medical School
– sequence: 29
  givenname: Choon Kiat
  orcidid: 0000-0001-6402-4288
  surname: Ong
  fullname: Ong, Choon Kiat
  organization: Duke-NUS Graduate Medical School, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (ASTAR)
– sequence: 30
  givenname: Dachuan
  orcidid: 0000-0002-7518-4081
  surname: Huang
  fullname: Huang, Dachuan
  organization: Division of Cellular and Molecular Research, National Cancer Centre Singapore
– sequence: 31
  givenname: Siok-Bian
  surname: Ng
  fullname: Ng, Siok-Bian
  organization: Cancer Science Institute (CSI), National University of Singapore, Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore
– sequence: 32
  givenname: Emily
  surname: Bernstein
  fullname: Bernstein, Emily
  organization: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
– sequence: 33
  givenname: Dan
  surname: Hasson
  fullname: Hasson, Dan
  organization: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
– sequence: 34
  givenname: Keng Boon
  surname: Wee
  fullname: Wee, Keng Boon
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 35
  givenname: Philipp
  orcidid: 0000-0002-7247-7591
  surname: Kaldis
  fullname: Kaldis, Philipp
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR)
– sequence: 36
  givenname: Anand
  orcidid: 0000-0001-9816-6137
  surname: Jeyasekharan
  fullname: Jeyasekharan, Anand
  organization: Cancer Science Institute (CSI), National University of Singapore
– sequence: 37
  givenname: David
  surname: Dominguez-sola
  fullname: Dominguez-sola, David
  organization: Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Immunology Institute and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
– sequence: 38
  givenname: Ivan
  orcidid: 0000-0002-5510-9762
  surname: Topisirovic
  fullname: Topisirovic, Ivan
  email: ivan.topisirovic@mcgill.ca
  organization: Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University, Lady Davis Institute, SMBD JGH, McGill University, Departments of Experimental Medicine and Biochemistry, McGill University
– sequence: 39
  givenname: Ernesto
  surname: Guccione
  fullname: Guccione, Ernesto
  email: ernesto.guccione@mssm.edu
  organization: Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (ASTAR), Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Mount Sinai Center for Therapeutics Discovery, Department of Oncological and Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32665551$$D View this record in MEDLINE/PubMed
BookMark eNp9Ustu1TAQtVARfdAfYIEssWET8DO2N0hQClQqAlWwtsaOc5tLEl_sBOn-PU5TSssCb_yYM-fMjM8xOhjjGBB6RskrSrh-nQUVtaoIIxVVpBYVeYSOGBG0XBk_uHc-RKc5b0lZ3FAtxBN0yFldSynpEbr6evX-M5W4yxjwj7DHKWzmHqaYcGzxECZwse_ygH3qps5Dj6eI85wn6Eb8rvKh73G_H3bXcYBNGEPu8lP0uIU-h9Pb_QR9_3D-7exTdfnl48XZ28vKS0GmyjjKaqI4uMaBbDyXxnntHdVKgzGeOG44B8ohaE2NUKAp57oWjfNAQfMTdLHyNhG2dpe6AdLeRujszUNMGwup1NwHa5pWtk2RJcELFYw2hDfcLSKCeecK15uVaze7ITQ-jFOC_gHpw8jYXdtN_GUVLz0oVQhe3hKk-HMOebJDl5fpwBjinC0TTBCjWS0L9MU_0G2c01hGtaB4LSlRpKDYivIp5pxCe1cMJXZxgF0dYIsD7I0D7JL0_H4bdyl__rsA-ArIJTRuQvqr_R_a3wutvMc
CitedBy_id crossref_primary_10_1021_acschemneuro_3c00456
crossref_primary_10_1186_s12967_023_04066_x
crossref_primary_10_1038_s41467_022_35469_x
crossref_primary_10_1038_s41598_021_94128_1
crossref_primary_10_1016_j_xcrm_2023_101050
crossref_primary_10_1186_s13046_023_02844_5
crossref_primary_10_1667_RADE_23_00018_1
crossref_primary_10_1038_s41419_022_05402_7
crossref_primary_10_3390_ijms222112030
crossref_primary_10_3390_ijms24065583
crossref_primary_10_1111_cas_15995
crossref_primary_10_3390_cells12010037
crossref_primary_10_1111_febs_15844
crossref_primary_10_3390_ijms24021327
crossref_primary_10_3390_jcm11082145
crossref_primary_10_1152_physiolgenomics_00129_2022
Cites_doi 10.1038/onc.2011.12
10.1093/nar/gkq1287
10.1155/2017/1726078
10.1038/nature14351
10.1038/nature07823
10.1093/bioinformatics/btr189
10.1038/nbt.1630
10.1006/geno.1996.0249
10.1038/nature10163
10.1097/01.pas.0000168176.71405.e5
10.1016/j.ccell.2016.02.018
10.1084/jem.20052204
10.1158/0008-5472.CAN-08-1329
10.2353/ajpath.2010.091291
10.1371/journal.pone.0003823
10.1016/j.stem.2012.12.012
10.1038/nsmb.2000
10.1056/NEJMoa1403352
10.3322/caac.21254
10.1186/1471-2148-7-187
10.1038/leu.2017.81
10.1093/bioinformatics/bts635
10.1016/j.trecan.2017.01.005
10.15252/embj.201696151
10.3109/07357907.2010.494323
10.1158/1535-7163.MCT-13-0044
10.1038/onc.2010.640
10.4155/fmc.09.89
10.1126/sciadv.aax9852
10.1016/j.ccr.2010.10.030
10.1007/BF02983534
10.1038/sj.leu.2404529
10.4049/jimmunol.1203471
10.1016/j.gde.2016.03.009
10.1006/geno.1996.0516
10.1016/j.cmet.2018.09.001
10.18632/oncotarget.22655
10.1016/j.tibs.2010.05.003
10.1038/ng.3922
10.1182/blood-2005-09-3778
10.1038/ni0707-665
10.1200/JCO.2011.41.0985
10.1007/s11523-011-0167-8
10.1074/jbc.273.26.15933
10.1101/cshperspect.a014217
10.1182/blood-2011-01-293050
10.1101/gad.870101
10.1016/j.cmet.2017.09.006
10.2741/Huang
ContentType Journal Article
Copyright The Author(s) 2020
The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2020
– notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-020-17064-0
DatabaseName Springer Open Access
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni Edition)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Database‎ (1962 - current)
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
ProQuest Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
Health Research Premium Collection
Natural Science Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Technology Collection
Technology Research Database
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef

Publicly Available Content Database
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: SpringerOpen
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 3520
ExternalDocumentID oai_doaj_org_article_9df5fd5400ec47e98903d3b9c0b42cbb
10_1038_s41467_020_17064_0
32665551
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: Center for Strategic Scientific Initiatives, National Cancer Institute (NCI Center for Strategic Scientific Initiatives)
  grantid: P30 CA196521
  funderid: https://doi.org/10.13039/100008637
– fundername: NCI NIH HHS
  grantid: R01 CA154683
– fundername: NCI NIH HHS
  grantid: P30 CA196521
– fundername: ;
  grantid: P30 CA196521
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADRAZ
AENEX
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
ID FETCH-LOGICAL-c540t-9b126073abdba5dc359bc8cb1878a99c0b3933a13ae881947a8133864dbca1a83
IEDL.DBID RPM
ISSN 2041-1723
IngestDate Tue Oct 22 15:16:35 EDT 2024
Tue Sep 17 21:14:20 EDT 2024
Sat Oct 26 05:30:50 EDT 2024
Thu Oct 10 15:46:07 EDT 2024
Fri Aug 23 00:40:32 EDT 2024
Tue Oct 29 09:14:17 EDT 2024
Fri Oct 11 20:38:06 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-9b126073abdba5dc359bc8cb1878a99c0b3933a13ae881947a8133864dbca1a83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0001-6402-4288
0000-0002-7247-7591
0000-0001-9816-6137
0000-0002-0521-1646
0000-0002-5510-9762
0000-0002-0364-6080
0000-0001-9756-976X
0000-0001-7585-7760
0000-0002-7518-4081
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360777/
PMID 32665551
PQID 2423651070
PQPubID 546298
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_9df5fd5400ec47e98903d3b9c0b42cbb
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7360777
proquest_miscellaneous_2424098265
proquest_journals_2423651070
crossref_primary_10_1038_s41467_020_17064_0
pubmed_primary_32665551
springer_journals_10_1038_s41467_020_17064_0
PublicationCentury 2000
PublicationDate 2020-07-14
PublicationDateYYYYMMDD 2020-07-14
PublicationDate_xml – month: 07
  year: 2020
  text: 2020-07-14
  day: 14
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Huang, Shao, Liu (CR11) 1998; 273
Alexander, Schrader, Adams (CR29) 1987; 7
Zhang (CR50) 2008; 9
Faes, Demartines, Dormond (CR36) 2017; 2017
Mzoughi (CR26) 2017; 49
Hulea (CR46) 2018; 28
Bertrand (CR6) 2007; 21
Mulvihill (CR32) 2009; 1
Skarnes (CR27) 2011; 474
Ekins, Nikolsky, Bugrim, Kirillov, Nikolskaya (CR53) 2007; 356
Mzoughi, Tan, Low, Guccione (CR12) 2016; 36
Johnson (CR3) 2012; 30
Ueda, Nishikori, Kitawaki, Uchiyama, Ohno (CR4) 2004; 79
CR2
Schmidt-Supprian, Rajewsky (CR48) 2007; 8
Pasqualucci (CR13) 2006; 203
Wagle (CR33) 2014; 371
CR42
Shadat (CR21) 2010; 28
Buyse, Takahashi, Huang (CR19) 1996; 34
Giallourakis (CR24) 2013; 190
Langmead, Trapnell, Pop, Salzberg (CR49) 2009; 10
Huang (CR17) 1999; 4
Garofalo (CR34) 2011; 30
Mock, Liu, LePaslier, Huang (CR18) 1996; 37
Mori (CR30) 2008; 68
Machanick, Bailey (CR54) 2011; 27
Zhang, Pavlova, Thompson (CR44) 2017; 36
Ma, Swigut, Valouev, Rada-Iglesias, Wysocka (CR8) 2011; 18
Yamaji (CR9) 2013; 12
Mzoughi (CR28) 2020; 6
Rempel (CR31) 2014; 13
Cluntun, Lukey, Cerione, Locasale (CR45) 2017; 3
Wise, Thompson (CR43) 2010; 35
Andrzejewski (CR47) 2017; 26
Fumasoni (CR10) 2007; 7
Poulain (CR39) 2017; 31
Nie (CR15) 2010; 177
Dobin (CR55) 2013; 29
McLean (CR51) 2010; 28
Min (CR35) 2015; 14
Siegel, Miller, Jemal (CR1) 2015; 65
Pusapati (CR40) 2016; 29
Tam (CR16) 2006; 107
Dettman, Justice (CR22) 2008; 3
Carew, Kelly, Nawrocki (CR37) 2011; 6
Koh (CR38) 2017; 8
CR23
Liu (CR7) 2007; 6
Steele-Perkins (CR20) 2001; 15
Mandelbaum (CR14) 2010; 18
Ye (CR52) 2011; 39
Haralambieva (CR5) 2005; 29
Koh (CR25) 2015; 523
Gao (CR41) 2009; 458
S Mzoughi (17064_CR12) 2016; 36
Y Zhang (17064_CR50) 2008; 9
P Bertrand (17064_CR6) 2007; 21
WS Alexander (17064_CR29) 1987; 7
S Huang (17064_CR17) 1999; 4
P Gao (17064_CR41) 2009; 458
C Ueda (17064_CR4) 2004; 79
G Steele-Perkins (17064_CR20) 2001; 15
S Ekins (17064_CR53) 2007; 356
RE Rempel (17064_CR31) 2014; 13
DR Wise (17064_CR43) 2010; 35
BA Mock (17064_CR18) 1996; 37
W Tam (17064_CR16) 2006; 107
JS Carew (17064_CR37) 2011; 6
HY Min (17064_CR35) 2015; 14
CC Giallourakis (17064_CR24) 2013; 190
C Garofalo (17064_CR34) 2011; 30
N Wagle (17064_CR33) 2014; 371
L Pasqualucci (17064_CR13) 2006; 203
17064_CR42
KX Koh (17064_CR38) 2017; 8
Z Ma (17064_CR8) 2011; 18
IM Buyse (17064_CR19) 1996; 34
CM Koh (17064_CR25) 2015; 523
RL Siegel (17064_CR1) 2015; 65
J Mandelbaum (17064_CR14) 2010; 18
WC Skarnes (17064_CR27) 2011; 474
L Hulea (17064_CR46) 2018; 28
NA Johnson (17064_CR3) 2012; 30
MJ Mulvihill (17064_CR32) 2009; 1
A Dobin (17064_CR55) 2013; 29
17064_CR2
S Mzoughi (17064_CR28) 2020; 6
J Zhang (17064_CR44) 2017; 36
AA Cluntun (17064_CR45) 2017; 3
RV Pusapati (17064_CR40) 2016; 29
NM Shadat (17064_CR21) 2010; 28
L Poulain (17064_CR39) 2017; 31
K Nie (17064_CR15) 2010; 177
EJ Dettman (17064_CR22) 2008; 3
D Liu (17064_CR7) 2007; 6
S Huang (17064_CR11) 1998; 273
B Langmead (17064_CR49) 2009; 10
P Machanick (17064_CR54) 2011; 27
17064_CR23
M Schmidt-Supprian (17064_CR48) 2007; 8
M Yamaji (17064_CR9) 2013; 12
S Mzoughi (17064_CR26) 2017; 49
S Andrzejewski (17064_CR47) 2017; 26
S Faes (17064_CR36) 2017; 2017
E Haralambieva (17064_CR5) 2005; 29
I Fumasoni (17064_CR10) 2007; 7
CY McLean (17064_CR51) 2010; 28
S Mori (17064_CR30) 2008; 68
T Ye (17064_CR52) 2011; 39
References_xml – volume: 3
  start-page: 169
  year: 2017
  end-page: 180
  ident: CR45
  article-title: Glutamine metabolism in cancer: understanding the heterogeneity
  publication-title: Trends Cancer
  contributor:
    fullname: Locasale
– volume: 18
  start-page: 120
  year: 2011
  end-page: 127
  ident: CR8
  article-title: Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates
  publication-title: Nat. Struct. Mol. Biol.
  contributor:
    fullname: Wysocka
– volume: 356
  start-page: 319
  year: 2007
  end-page: 350
  ident: CR53
  article-title: Pathway mapping tools for analysis of high content data
  publication-title: Methods Mol. Biol.
  contributor:
    fullname: Nikolskaya
– volume: 34
  start-page: 119
  year: 1996
  end-page: 121
  ident: CR19
  article-title: Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36
  publication-title: Genomics
  contributor:
    fullname: Huang
– volume: 27
  start-page: 1696
  year: 2011
  end-page: 1697
  ident: CR54
  article-title: MEME-ChIP: motif analysis of large DNA datasets
  publication-title: Bioinformatics
  contributor:
    fullname: Bailey
– volume: 8
  start-page: 110133
  year: 2017
  end-page: 110144
  ident: CR38
  article-title: Acquired resistance to PI3K/mTOR inhibition is associated with mitochondrial DNA mutation and glycolysis
  publication-title: Oncotarget
  contributor:
    fullname: Koh
– volume: 15
  start-page: 2250
  year: 2001
  end-page: 2262
  ident: CR20
  article-title: Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily
  publication-title: Genes Dev.
  contributor:
    fullname: Steele-Perkins
– volume: 28
  start-page: 806
  year: 2010
  end-page: 812
  ident: CR21
  article-title: Retinoblastoma protein-interacting zinc finger 1 (RIZ1) regulates the proliferation of monocytic leukemia cells via activation of p53
  publication-title: Cancer Investig.
  contributor:
    fullname: Shadat
– volume: 474
  start-page: 337
  year: 2011
  end-page: 342
  ident: CR27
  article-title: A conditional knockout resource for the genome-wide study of mouse gene function
  publication-title: Nature
  contributor:
    fullname: Skarnes
– ident: CR42
– volume: 28
  start-page: 495
  year: 2010
  end-page: 501
  ident: CR51
  article-title: GREAT improves functional interpretation of cis-regulatory regions
  publication-title: Nat. Biotechnol.
  contributor:
    fullname: McLean
– volume: 29
  start-page: 548
  year: 2016
  end-page: 562
  ident: CR40
  article-title: mTORC1-dependent metabolic reprogramming underlies escape from glycolysis addiction in cancer cells
  publication-title: Cancer Cell
  contributor:
    fullname: Pusapati
– volume: 18
  start-page: 568
  year: 2010
  end-page: 579
  ident: CR14
  article-title: BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma
  publication-title: Cancer Cell
  contributor:
    fullname: Mandelbaum
– volume: 28
  start-page: 817
  year: 2018
  end-page: 832 e818
  ident: CR46
  article-title: Translational and HIF-1alpha-dependent metabolic reprogramming underpin metabolic plasticity and responses to kinase inhibitors and biguanides
  publication-title: Cell Metab.
  contributor:
    fullname: Hulea
– volume: 107
  start-page: 4090
  year: 2006
  end-page: 4100
  ident: CR16
  article-title: Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas
  publication-title: Blood
  contributor:
    fullname: Tam
– volume: 68
  start-page: 8525
  year: 2008
  end-page: 8534
  ident: CR30
  article-title: Utilization of pathway signatures to reveal distinct types of B lymphoma in the Emicro-myc model and human diffuse large B-cell lymphoma
  publication-title: Cancer Res.
  contributor:
    fullname: Mori
– volume: 7
  start-page: 1436
  year: 1987
  end-page: 1444
  ident: CR29
  article-title: Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: Adams
– volume: 273
  start-page: 15933
  year: 1998
  end-page: 15939
  ident: CR11
  article-title: The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Liu
– volume: 37
  start-page: 24
  year: 1996
  end-page: 28
  ident: CR18
  article-title: The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10
  publication-title: Genomics
  contributor:
    fullname: Huang
– volume: 31
  start-page: 2326
  year: 2017
  end-page: 2335
  ident: CR39
  article-title: High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells
  publication-title: Leukemia
  contributor:
    fullname: Poulain
– volume: 1
  start-page: 1153
  year: 2009
  end-page: 1171
  ident: CR32
  article-title: Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor
  publication-title: Future Med. Chem.
  contributor:
    fullname: Mulvihill
– volume: 3
  start-page: e3823
  year: 2008
  ident: CR22
  article-title: The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32
  publication-title: PLoS ONE
  contributor:
    fullname: Justice
– volume: 26
  start-page: 778
  year: 2017
  end-page: 787 e775
  ident: CR47
  article-title: PGC-1alpha promotes breast cancer metastasis and confers bioenergetic flexibility against metabolic drugs
  publication-title: Cell Metab.
  contributor:
    fullname: Andrzejewski
– volume: 6
  start-page: 17
  year: 2011
  end-page: 27
  ident: CR37
  article-title: Mechanisms of mTOR inhibitor resistance in cancer therapy
  publication-title: Target Oncol.
  contributor:
    fullname: Nawrocki
– volume: 30
  start-page: 3452
  year: 2012
  end-page: 3459
  ident: CR3
  article-title: Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone
  publication-title: J. Clin. Oncol.
  contributor:
    fullname: Johnson
– volume: 190
  start-page: 5578
  year: 2013
  end-page: 5587
  ident: CR24
  article-title: Genome-wide analysis of immune system genes by expressed sequence Tag profiling
  publication-title: J. Immunol.
  contributor:
    fullname: Giallourakis
– volume: 36
  start-page: 1302
  year: 2017
  end-page: 1315
  ident: CR44
  article-title: Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine
  publication-title: Embo J.
  contributor:
    fullname: Thompson
– volume: 39
  start-page: e35
  year: 2011
  ident: CR52
  article-title: seqMINER: an integrated ChIP-seq data interpretation platform
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Ye
– volume: 2017
  start-page: 1726078
  year: 2017
  ident: CR36
  article-title: Resistance to mTORC1 inhibitors in cancer therapy: from kinase mutations to intratumoral heterogeneity of kinase activity
  publication-title: Oxid. Med. Cell. Longev.
  contributor:
    fullname: Dormond
– volume: 458
  start-page: 762
  year: 2009
  end-page: 765
  ident: CR41
  article-title: c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
  publication-title: Nature
  contributor:
    fullname: Gao
– volume: 4
  start-page: D528
  year: 1999
  end-page: D532
  ident: CR17
  article-title: The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers
  publication-title: Front. Biosci.
  contributor:
    fullname: Huang
– volume: 10
  year: 2009
  ident: CR49
  article-title: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
  publication-title: Genome Biol.
  contributor:
    fullname: Salzberg
– volume: 12
  start-page: 368
  year: 2013
  end-page: 382
  ident: CR9
  article-title: PRDM14 ensures naive pluripotency through dual regulation of signaling and epigenetic pathways in mouse embryonic stem cells
  publication-title: Cell Stem Cell
  contributor:
    fullname: Yamaji
– ident: CR2
– volume: 6
  start-page: eaax9852
  year: 2020
  ident: CR28
  article-title: PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly
  publication-title: Sci. Adv.
  contributor:
    fullname: Mzoughi
– volume: 79
  start-page: 52
  year: 2004
  end-page: 54
  ident: CR4
  article-title: Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma
  publication-title: Int. J. Hematol.
  contributor:
    fullname: Ohno
– volume: 49
  start-page: 1354
  year: 2017
  end-page: 1363
  ident: CR26
  article-title: PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling
  publication-title: Nat. Genet.
  contributor:
    fullname: Mzoughi
– volume: 523
  start-page: 96
  year: 2015
  end-page: 100
  ident: CR25
  article-title: MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
  publication-title: Nature
  contributor:
    fullname: Koh
– volume: 29
  start-page: 1086
  year: 2005
  end-page: 1094
  ident: CR5
  article-title: Clinical, immunophenotypic, and genetic analysis of adult lymphomas with morphologic features of Burkitt lymphoma
  publication-title: Am. J. Surg. Pathol.
  contributor:
    fullname: Haralambieva
– volume: 30
  start-page: 2730
  year: 2011
  end-page: 2740
  ident: CR34
  article-title: Efficacy of and resistance to anti-IGF-1R therapies in Ewing’s sarcoma is dependent on insulin receptor signaling
  publication-title: Oncogene
  contributor:
    fullname: Garofalo
– ident: CR23
– volume: 14
  year: 2015
  ident: CR35
  article-title: Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer
  publication-title: Mol. Cancer
  contributor:
    fullname: Min
– volume: 6
  year: 2007
  ident: CR7
  article-title: t(8;14;18): a 3-way chromosome translocation in two patients with Burkitt’s lymphoma/leukemia
  publication-title: Mol. Cancer
  contributor:
    fullname: Liu
– volume: 13
  start-page: 3219
  year: 2014
  end-page: 3229
  ident: CR31
  article-title: Utilization of the Emu-Myc mouse to model heterogeneity of therapeutic response
  publication-title: Mol. Cancer Ther.
  contributor:
    fullname: Rempel
– volume: 371
  start-page: 1426
  year: 2014
  end-page: 1433
  ident: CR33
  article-title: Response and acquired resistance to everolimus in anaplastic thyroid cancer
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Wagle
– volume: 29
  start-page: 15
  year: 2013
  end-page: 21
  ident: CR55
  article-title: STAR: ultrafast universal RNA-seq aligner
  publication-title: Bioinformatics
  contributor:
    fullname: Dobin
– volume: 7
  year: 2007
  ident: CR10
  article-title: Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates
  publication-title: BMC Evol. Biol.
  contributor:
    fullname: Fumasoni
– volume: 21
  start-page: 515
  year: 2007
  end-page: 523
  ident: CR6
  article-title: Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas
  publication-title: Leukemia
  contributor:
    fullname: Bertrand
– volume: 36
  start-page: 83
  year: 2016
  end-page: 91
  ident: CR12
  article-title: The role of PRDMs in cancer: one family, two sides
  publication-title: Curr. Opin. Genet. Dev.
  contributor:
    fullname: Guccione
– volume: 9
  year: 2008
  ident: CR50
  article-title: Model-based analysis of ChIP-Seq (MACS)
  publication-title: Genome Biol.
  contributor:
    fullname: Zhang
– volume: 35
  start-page: 427
  year: 2010
  end-page: 433
  ident: CR43
  article-title: Glutamine addiction: a new therapeutic target in cancer
  publication-title: Trends Biochem. Sci.
  contributor:
    fullname: Thompson
– volume: 177
  start-page: 1470
  year: 2010
  end-page: 1479
  ident: CR15
  article-title: Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7
  publication-title: Am. J. Pathol.
  contributor:
    fullname: Nie
– volume: 8
  start-page: 665
  year: 2007
  end-page: 668
  ident: CR48
  article-title: Vagaries of conditional gene targeting
  publication-title: Nat. Immunol.
  contributor:
    fullname: Rajewsky
– volume: 203
  start-page: 311
  year: 2006
  end-page: 317
  ident: CR13
  article-title: Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma
  publication-title: J. Exp. Med.
  contributor:
    fullname: Pasqualucci
– volume: 65
  start-page: 5
  year: 2015
  end-page: 29
  ident: CR1
  article-title: Cancer statistics, 2015
  publication-title: CA Cancer J. Clin.
  contributor:
    fullname: Jemal
– volume: 9
  year: 2008
  ident: 17064_CR50
  publication-title: Genome Biol.
  contributor:
    fullname: Y Zhang
– volume: 6
  year: 2007
  ident: 17064_CR7
  publication-title: Mol. Cancer
  contributor:
    fullname: D Liu
– ident: 17064_CR23
  doi: 10.1038/onc.2011.12
– volume: 14
  year: 2015
  ident: 17064_CR35
  publication-title: Mol. Cancer
  contributor:
    fullname: HY Min
– volume: 39
  start-page: e35
  year: 2011
  ident: 17064_CR52
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkq1287
  contributor:
    fullname: T Ye
– volume: 10
  year: 2009
  ident: 17064_CR49
  publication-title: Genome Biol.
  contributor:
    fullname: B Langmead
– volume: 2017
  start-page: 1726078
  year: 2017
  ident: 17064_CR36
  publication-title: Oxid. Med. Cell. Longev.
  doi: 10.1155/2017/1726078
  contributor:
    fullname: S Faes
– volume: 523
  start-page: 96
  year: 2015
  ident: 17064_CR25
  publication-title: Nature
  doi: 10.1038/nature14351
  contributor:
    fullname: CM Koh
– volume: 458
  start-page: 762
  year: 2009
  ident: 17064_CR41
  publication-title: Nature
  doi: 10.1038/nature07823
  contributor:
    fullname: P Gao
– volume: 27
  start-page: 1696
  year: 2011
  ident: 17064_CR54
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btr189
  contributor:
    fullname: P Machanick
– volume: 28
  start-page: 495
  year: 2010
  ident: 17064_CR51
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.1630
  contributor:
    fullname: CY McLean
– volume: 34
  start-page: 119
  year: 1996
  ident: 17064_CR19
  publication-title: Genomics
  doi: 10.1006/geno.1996.0249
  contributor:
    fullname: IM Buyse
– volume: 474
  start-page: 337
  year: 2011
  ident: 17064_CR27
  publication-title: Nature
  doi: 10.1038/nature10163
  contributor:
    fullname: WC Skarnes
– volume: 29
  start-page: 1086
  year: 2005
  ident: 17064_CR5
  publication-title: Am. J. Surg. Pathol.
  doi: 10.1097/01.pas.0000168176.71405.e5
  contributor:
    fullname: E Haralambieva
– volume: 29
  start-page: 548
  year: 2016
  ident: 17064_CR40
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2016.02.018
  contributor:
    fullname: RV Pusapati
– volume: 203
  start-page: 311
  year: 2006
  ident: 17064_CR13
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20052204
  contributor:
    fullname: L Pasqualucci
– volume: 68
  start-page: 8525
  year: 2008
  ident: 17064_CR30
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-1329
  contributor:
    fullname: S Mori
– volume: 177
  start-page: 1470
  year: 2010
  ident: 17064_CR15
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2010.091291
  contributor:
    fullname: K Nie
– volume: 3
  start-page: e3823
  year: 2008
  ident: 17064_CR22
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0003823
  contributor:
    fullname: EJ Dettman
– volume: 12
  start-page: 368
  year: 2013
  ident: 17064_CR9
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.12.012
  contributor:
    fullname: M Yamaji
– volume: 18
  start-page: 120
  year: 2011
  ident: 17064_CR8
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2000
  contributor:
    fullname: Z Ma
– volume: 371
  start-page: 1426
  year: 2014
  ident: 17064_CR33
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1403352
  contributor:
    fullname: N Wagle
– volume: 65
  start-page: 5
  year: 2015
  ident: 17064_CR1
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.21254
  contributor:
    fullname: RL Siegel
– volume: 7
  year: 2007
  ident: 17064_CR10
  publication-title: BMC Evol. Biol.
  doi: 10.1186/1471-2148-7-187
  contributor:
    fullname: I Fumasoni
– volume: 31
  start-page: 2326
  year: 2017
  ident: 17064_CR39
  publication-title: Leukemia
  doi: 10.1038/leu.2017.81
  contributor:
    fullname: L Poulain
– volume: 29
  start-page: 15
  year: 2013
  ident: 17064_CR55
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
  contributor:
    fullname: A Dobin
– volume: 3
  start-page: 169
  year: 2017
  ident: 17064_CR45
  publication-title: Trends Cancer
  doi: 10.1016/j.trecan.2017.01.005
  contributor:
    fullname: AA Cluntun
– volume: 36
  start-page: 1302
  year: 2017
  ident: 17064_CR44
  publication-title: Embo J.
  doi: 10.15252/embj.201696151
  contributor:
    fullname: J Zhang
– volume: 28
  start-page: 806
  year: 2010
  ident: 17064_CR21
  publication-title: Cancer Investig.
  doi: 10.3109/07357907.2010.494323
  contributor:
    fullname: NM Shadat
– volume: 13
  start-page: 3219
  year: 2014
  ident: 17064_CR31
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-13-0044
  contributor:
    fullname: RE Rempel
– volume: 30
  start-page: 2730
  year: 2011
  ident: 17064_CR34
  publication-title: Oncogene
  doi: 10.1038/onc.2010.640
  contributor:
    fullname: C Garofalo
– volume: 1
  start-page: 1153
  year: 2009
  ident: 17064_CR32
  publication-title: Future Med. Chem.
  doi: 10.4155/fmc.09.89
  contributor:
    fullname: MJ Mulvihill
– volume: 6
  start-page: eaax9852
  year: 2020
  ident: 17064_CR28
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aax9852
  contributor:
    fullname: S Mzoughi
– volume: 18
  start-page: 568
  year: 2010
  ident: 17064_CR14
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2010.10.030
  contributor:
    fullname: J Mandelbaum
– volume: 79
  start-page: 52
  year: 2004
  ident: 17064_CR4
  publication-title: Int. J. Hematol.
  doi: 10.1007/BF02983534
  contributor:
    fullname: C Ueda
– volume: 21
  start-page: 515
  year: 2007
  ident: 17064_CR6
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2404529
  contributor:
    fullname: P Bertrand
– volume: 190
  start-page: 5578
  year: 2013
  ident: 17064_CR24
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1203471
  contributor:
    fullname: CC Giallourakis
– volume: 36
  start-page: 83
  year: 2016
  ident: 17064_CR12
  publication-title: Curr. Opin. Genet. Dev.
  doi: 10.1016/j.gde.2016.03.009
  contributor:
    fullname: S Mzoughi
– volume: 37
  start-page: 24
  year: 1996
  ident: 17064_CR18
  publication-title: Genomics
  doi: 10.1006/geno.1996.0516
  contributor:
    fullname: BA Mock
– volume: 28
  start-page: 817
  year: 2018
  ident: 17064_CR46
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2018.09.001
  contributor:
    fullname: L Hulea
– volume: 8
  start-page: 110133
  year: 2017
  ident: 17064_CR38
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.22655
  contributor:
    fullname: KX Koh
– volume: 7
  start-page: 1436
  year: 1987
  ident: 17064_CR29
  publication-title: Mol. Cell. Biol.
  contributor:
    fullname: WS Alexander
– volume: 356
  start-page: 319
  year: 2007
  ident: 17064_CR53
  publication-title: Methods Mol. Biol.
  contributor:
    fullname: S Ekins
– volume: 35
  start-page: 427
  year: 2010
  ident: 17064_CR43
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2010.05.003
  contributor:
    fullname: DR Wise
– volume: 49
  start-page: 1354
  year: 2017
  ident: 17064_CR26
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3922
  contributor:
    fullname: S Mzoughi
– volume: 107
  start-page: 4090
  year: 2006
  ident: 17064_CR16
  publication-title: Blood
  doi: 10.1182/blood-2005-09-3778
  contributor:
    fullname: W Tam
– volume: 8
  start-page: 665
  year: 2007
  ident: 17064_CR48
  publication-title: Nat. Immunol.
  doi: 10.1038/ni0707-665
  contributor:
    fullname: M Schmidt-Supprian
– volume: 30
  start-page: 3452
  year: 2012
  ident: 17064_CR3
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2011.41.0985
  contributor:
    fullname: NA Johnson
– volume: 6
  start-page: 17
  year: 2011
  ident: 17064_CR37
  publication-title: Target Oncol.
  doi: 10.1007/s11523-011-0167-8
  contributor:
    fullname: JS Carew
– volume: 273
  start-page: 15933
  year: 1998
  ident: 17064_CR11
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.26.15933
  contributor:
    fullname: S Huang
– ident: 17064_CR42
  doi: 10.1101/cshperspect.a014217
– ident: 17064_CR2
  doi: 10.1182/blood-2011-01-293050
– volume: 15
  start-page: 2250
  year: 2001
  ident: 17064_CR20
  publication-title: Genes Dev.
  doi: 10.1101/gad.870101
  contributor:
    fullname: G Steele-Perkins
– volume: 26
  start-page: 778
  year: 2017
  ident: 17064_CR47
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2017.09.006
  contributor:
    fullname: S Andrzejewski
– volume: 4
  start-page: D528
  year: 1999
  ident: 17064_CR17
  publication-title: Front. Biosci.
  doi: 10.2741/Huang
  contributor:
    fullname: S Huang
SSID ssj0000391844
Score 2.4808438
Snippet PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate...
Abstract PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate...
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 3520
SubjectTerms 1-Phosphatidylinositol 3-kinase
38
38/15
38/91
631/337/2019
631/67/1990/291/1621/1915
64/60
96/106
96/95
AKT protein
Animals
Apoptosis - genetics
Apoptosis - physiology
B-cell lymphoma
Blotting, Western
Cancer
Cell death
Cell Survival - genetics
Cell Survival - physiology
Chromatin Immunoprecipitation
Computational Biology
Depletion
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Female
Flow Cytometry
Gene Expression Regulation - genetics
Gene Expression Regulation - physiology
Glycolysis
Homeostasis
Homology
Humanities and Social Sciences
Humans
Lymphocytes B
Lymphoma
Lymphoma - genetics
Lymphoma - metabolism
Metabolism
Mice
Mice, SCID
multidisciplinary
Oncology
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Random Allocation
Regulators
Science
Science (multidisciplinary)
Stem cells
TOR protein
Transcription
Transcription Factors - genetics
Transcription Factors - metabolism
Transcriptome - genetics
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhUMil9JGkbtOiQm6tiLySLOmYtA2hkBJCA7kJvUwXsnZZO4f8-4wk7ybbB730ZiyBxfdpRt9Y0gxCh9bXTcO9Jq0VinB4JFoKTlSQtA5eRB7Sfefzb83ZFf96La4flfpKZ8JKeuAC3JEOrWgD6AoaPZdRK01ZYE576vjMO5e9L9WPgqnsg5mG0IVPt2QoU0cDzz4hRUspYwwndGMlygn7_6Qyfz8s-cuOaV6ITp-hp5OCxMdl5M_RVuxeoCelpuTdS3R5cfn5vBZ4PmCLwULxslSb75e4b_EijsD6zXxYYD8VOcBjj4dyjQqfkPQjH9_cAcf9AlwNOML5sIuuTr98_3RGpsIJxANQI9GuhjBFMuuCsyJ4JrTzyrtaSWV1go5pxmzNbFSgCLi0KoWqDQ_O29oqtoe2u76LrxCmns6CDkm1gNYSrbbU2RBtS2fWuiZU6MMKRPOz5McweV-bKVMgNwC5yZAbWqGThPO6Z8ptnV8A42Zi3PyL8QodrFgyk8ENJsnCBvyLhG-8XzeDqSTYbBf729wHolmIp0SF9gup65GAim0EqMcKyQ26N4a62dLNf-R03JIB1lJW6ONqYjwM6-9QvP4fULxBO7M0o1OiT36AtsflbXwLIml077I93AMpgA3P
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELZgKyQuiDeBgozEDaw6sR3bJ8RCqwqpVbWiUm-WX4GVuknZpIf-e8aJd6vldYtiH8bz8jdjewahd9aXdc29Jo0VinD4JFoKTlSQtAxeRB7Se-eT0_r4nH-9EBc54dbna5Ubnzg66tD5lCM_SPt-DQok6cernyR1jUqnq7mFxl20V0GkUM3Q3vzw9GyxzbKk-ueK8_xahjJ10PPRN6SoKVWO4YTu7Ehj4f6_oc0_L03-dnI6bkhHD9GDjCTxp0n0j9Cd2D5G96bekjdP0OJs8eWkFHjZY4vBUvF66jrfrXHX4FUcQPqXy36FfW52gIcO99NzKjwnKaGPL29A1t0KXA44xGX_FJ0fHX77fExyAwXiAYgNRLsSwhXJrAvOiuCZ0M4r70olldXaU8c0Y7ZkNipABlxalULWmgfnbWkVe4ZmbdfGFwhTT6ugQ0IvgLlEoy11NkTb0MpaV4cCvd8w0VxNdTLMeL7NlJlYboDlZmS5oQWaJz5vZ6Ya1-OPbv3dZJMxOjSiCbAQGj2XUStNWWAukc0r71yB9jdSMtnwenOrJgV6ux0Gk0lss23srsc5ENVCXCUK9HwS6pYSQLO1ABRZILkj7h1Sd0fa5Y-xLLdkwGspC_Rhoxi3ZP2bFS__v4pX6H6VdDWV8uT7aDasr-NrgEGDe5N1_RdrcgW1
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals (Open Access)
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bi9QwFA7LiuCLeLe6SgTfNNo2SZM8iLjqsggrsjiwbyG3rgMzrbZdcP69J2k7Mjr6VpqUJt-59DtNcg5Cz40rqoo5RWrDJWFwSZTgjEgv8sI7HpiP553PPlenC_bpgl8coLnc0QRgvze0i_WkFt3q1c8fm7dg8G_GI-Pydc-SucdAKCaDYQRC-GtlTMwVt_JNdD95ZqogoGHT2Zn9j-58n1Ia_33c8-8tlH-so6bP08ktdHPilfjdqAi30UFo7qDrY6XJzV10_uX8w1nB8bLHBoPd4m6sQd92uK3xOgygC6tlv8ZuKn2Ahxb34-EqfEzi73282oDk2zU4IHCPy_4eWpx8_Pr-lEzlFIgDWjYQZQsIXgQ11lvDvaNcWSedLaSQRimXW6ooNQU1QQJPYMLIGMBWzFtnCiPpfXTYtE14iHDu8tIrH7kMMDBeK5Nb44Op89IYW_kMvZhB1N_HrBk6rXZTqUfINUCuE-Q6z9BxxHnbM2a8Tjfa7lJPBqSVr3ntYSJ5cEwEJVVOPbVx2Kx01mboaJaSnrVIR7JYgdcR8I5n22YwoAibaUJ7lfpAjAtRFs_Qg1Go25EAt604cMoMiR1x7wx1t6VZfktJugUFrIXI0MtZMX4P699QPPr_LB6jG2XU1ZjYkx2hw6G7Ck-AFA32adL0X0PYB4k
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Open Access
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEBYhIdBLSZM-nCZBhd5aUXklWdKx2TaEQkIJDeQm9DJdyNph7Rzy7zuSvRucpofejCXj8YxG-kbyfIPQR-vLquJek9oKRThcEi0FJypIWgYvIg8p3_nisjq_5j9uxM1Ik5NyYSbn90x96Xh25RTkJKIXTiA830lrcCrTMK_mm_2UxHSuOB_zYp5_dLL2ZIr-53Dl379HPjkjzUvP2R56OWJG_HUw8iu0FZt9tDtUkXw4QFc_r75dlAIvOmwx-CReDfXl2xVua7yMPdj5dtEtsR_LGuC-xd2QOIVPSdq6x7cPYNV2CZMLTH2L7jW6Pvv-a35OxlIJxAPk6ol2JQQmklkXnBXBM6GdV96VSiqrtaeOacZsyWxUgAG4tCoFpxUPztvSKvYGbTdtE98hTD2dBR0STgF0JWptqbMh2prOrHVVKNCntRLN3cCIYfJJNlNmULkBlZusckMLdJr0vOmZ2KzzDTCyGZ3D6FCLOsCH0Oi5jFppygJzSWw-884V6GhtJTO6WGcSEKxgRpHwjg-bZnCOpDbbxPY-94H4FSIoUaC3g1E3kgBurQTgxQLJibknok5bmsXvTMAtGehaygJ9Xg-MR7H-rYrD_-v-Hr2YpbGbSDz5EdruV_fxGABQ707yyP8DxXn9MQ
  priority: 102
  providerName: Springer Nature
Title PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis
URI https://link.springer.com/article/10.1038/s41467-020-17064-0
https://www.ncbi.nlm.nih.gov/pubmed/32665551
https://www.proquest.com/docview/2423651070
https://search.proquest.com/docview/2424098265
https://pubmed.ncbi.nlm.nih.gov/PMC7360777
https://doaj.org/article/9df5fd5400ec47e98903d3b9c0b42cbb
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9swFBdtx2CXse957YIGu21u5EiypGOSNSuBlJCtkJvRh90FErvE6aH_fZ9kO1v2cdnFNrZBz-9Lvyc_vYfQR22TNGVWxYXmMmZwGSvBWSydIImzPGfO73eeXaWX12y65MsjxLu9MCFp35rVebnenJerHyG38nZj-12eWH8-GwuaEiFE_xgdg4L-EqIH90sVRC2s3SBDqOzXLLgDHyj5YjEs9u3fALaknPPkYD4KZfv_hjX_TJn87b9pmI4mz9DTFkfiYUPvc3SUly_Q46az5P1LtJgvvswSjlc11hjsFG-bnvPVFlcF3uQ7kP16VW-wbVsd4F2F62YzFR7Ffjkfr-9B0tUGHA64w1X9Cl1PLr6PL-O2fUJsAYbtYmUSCFYE1cYZzZ2lXBkrrUmkkFopSwxVlOqE6lwCLmBCSx-wpswZqxMt6Wt0UlZl_hZhYsnAKeexCyAuXihNjHa5LshAa5O6CH3qmJjdNlUysvB3m8qs4X4G3M8C9zMSoZHn8_5NX-E63Ki2N1kr50y5ghcOPoTklolcSUWoo8aTzQbWmAiddVLKWrOrMw8OU_AyAsb4sH8MBuPZpsu8ugvvQEwLURWP0JtGqHtKOqWIkDgQ9wGph09AR0NR7lYnI_S5U4yfZP2bFe_-e6BT9GTgNdrX-GRn6GS3vcvfAz7amR5YxVLAUU6-9tCj4XD6bQrn0cXVfAF3x-m4F1Ye4Dhjshes5wHUHhUO
link.rule.ids 230,315,730,783,787,867,888,2109,12070,12779,21402,24332,27938,27939,31733,31734,33387,33388,33758,33759,41134,42203,43324,43614,43819,51590,53806,53808,74081,74371,74638
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Jb9QwFLagCMEFsRMoYCRuYNUZ27F9QhSoBuhUqGqluVneAiN1kjJJD_33PDuZqYbtFsU-2G_z97x8D6HX1pdVxb0mtRWKcPgkWgpOVJC0DF5EHtJ759lRNT3lX-ZiPm64deO1ynVMzIE6tD7tke-ldb8CA5L03flPkqpGpdPVsYTGdXQj8XAl7nw5l5s9lsR-rjgf38pQpvY6niNDypkSbwwndGs9yrT9f8Oaf16Z_O3cNC9HB3fRnRFH4veD4u-ha7G5j24OlSUvH6Djb8cfZ6XAiw5bDH6KV0PN-XaF2xovYw-6P1t0S-zHUge4b3E3PKbC-yRt5-OzS9B0u4SAA-Fw0T1EpwefTj5MyVg-gXiAYT3RroRkRTLrgrMieCa088q7UklltfbUMc2YLZmNCnABl1alhLXiwXlbWsUeoZ2mbeIThKmnk6BDwi6AuEStLXU2RFvTibWuCgV6sxaiOR9YMkw-3WbKDCI3IHKTRW5ogfaTnDc9E8N1_tGuvpvRYYwOtagDTIRGz2XUSlMWmEvD5hPvXIF211oyo9t15spICvRq0wwOk8Rmm9he5D6Q00JWJQr0eFDqZiSAZSsBGLJAckvdW0PdbmkWPzIpt2QgaykL9HZtGFfD-rconv5_Fi_RrenJ7NAcfj76-gzdniS7TaSefBft9KuL-BwAUe9eZKv_BXZjB0A
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LbxMxEB5BKhAXxJuFAkbiBqt6Y3ttnxChjcqjURRRqTfLj12I1GRLNj303zPedVKF12219mE8_mb8jR8zAG-sL8qSe53XVqic42eupeC5CpIWwYuKh_je-WRSHp_yz2fiLN1_atO1yo1P7Bx1aHzcIz-I636JAJL0oE7XIqaH4_cXP_NYQSqetKZyGjdhT3JE1QD2RkeT6Wy74xJzoSvO08sZytRByzs_ESOomEWG53RndeqS-P-Nef55gfK3U9RucRrfg7uJVZIPPQzuw41q-QBu9XUmrx7CbDo7PCkEmbfEErRasuor0Dcr0tRkUa0RCefzdkF8KnxA1g1p-6dVZJTHzX1yfoXz3izQ_aBznLeP4HR89O3jcZ6KKeQeSdk6167A0EUy64KzIngmtPPKu0JJZbX21DHNmC2YrRSyBC6tiuFryYPztrCKPYbBsllWT4FQT4dBh8hkkH-JWlvqbKhsTYfWujJk8HajRHPR58ww3Vk3U6ZXuUGVm07lhmYwinre9oz5rrsfzeq7SeZjdKhFHXAgtPJcVlppygJzUWw-9M5lsL-ZJZOMsDXXkMng9bYZzSeqzS6r5rLrgxEuxlgigyf9pG4lQWZbCmSUGcid6d4RdbdlOf_RpeiWDHUtZQbvNsC4Fuvfqnj2_1G8gtsIefP10-TLc7gzjLCNGT75PgzWq8vqBbKjtXuZYP8LgU0M4w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=PRDM15+is+a+key+regulator+of+metabolism+critical+to+sustain+B-cell+lymphomagenesis&rft.jtitle=Nature+communications&rft.au=Mzoughi+Slim&rft.au=Fong%2C+Jia+Yi&rft.au=Papadopoli%2C+David&rft.au=Koh%2C+Cheryl+M&rft.date=2020-07-14&rft.pub=Nature+Publishing+Group&rft.eissn=2041-1723&rft.volume=11&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-020-17064-0&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon