Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control

• Published in: Cell reports (Cambridge) Vol. 13; no. 7; pp. 1353 - 1365
• Main Authors: Trusel, Massimo, Cavaccini, Anna, Gritti, Marta, Greco, Barbara, Saintot, Pierre-Philippe, Nazzaro, Cristiano, Cerovic, Milica, Morella, Ilaria, Brambilla, Riccardo, Tonini, Raffaella
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.11.2015; Elsevier
• Subjects: Adenosine - physiology; Animals; Cerebral Cortex - cytology; Cerebral Cortex - pathology; Corpus Striatum - pathology; Dopamine - physiology; Dopaminergic Neurons - physiology; Excitatory Postsynaptic Potentials; Long-Term Synaptic Depression; MAP Kinase Signaling System; Mice; Motor Activity; Neuronal Plasticity; Parkinson Disease, Secondary - chemically induced; Parkinson Disease, Secondary - pathology; Receptor, Adenosine A1 - metabolism; Small-Conductance Calcium-Activated Potassium Channels - metabolism; Substantia Nigra - pathology

The basal ganglia play a critical role in shaping motor behavior. For this function, the activity of medium spiny neurons (MSNs) of the striatonigral and striatopallidal pathways must be integrated. It remains unclear whether the activity of the two pathways is primarily coordinated by synaptic plas...